Clustering_results_report
2024-01-24
1 Clustring Processed data without auxiliary variables
1.1 Imporved Deep Empedding Clustering on the encoded data 6 clusters
1.1.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=266) | 1 (N=881) | 2 (N=1135) | 3 (N=468) | 4 (N=129) | 5 (N=222) | Total (N=3101) | p value | |
|---|---|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||||
| Â Â Â Mean (SD) | 56.000 (14.812) | 61.959 (10.193) | 39.788 (12.281) | 47.816 (13.477) | 67.380 (8.054) | 48.766 (14.804) | 50.480 (15.626) | |
| Â Â Â Range | 18.000 - 82.000 | 25.000 - 97.000 | 17.000 - 75.000 | 17.000 - 80.000 | 47.000 - 86.000 | 19.000 - 81.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | |||||||
| Â Â Â No | 108 (40.6%) | 472 (53.6%) | 486 (42.8%) | 146 (31.2%) | 42 (32.6%) | 80 (36.0%) | 1334 (43.0%) | |
| Â Â Â Yes | 158 (59.4%) | 409 (46.4%) | 649 (57.2%) | 322 (68.8%) | 87 (67.4%) | 142 (64.0%) | 1767 (57.0%) | |
| BMI | < 0.001 | |||||||
| Â Â Â Mean (SD) | 27.306 (5.106) | 27.342 (4.465) | 25.071 (4.004) | 27.359 (4.839) | 30.093 (4.748) | 27.216 (5.132) | 26.616 (4.665) | |
| Â Â Â Range | 17.668 - 50.058 | 17.296 - 48.870 | 16.534 - 46.094 | 17.029 - 44.444 | 20.292 - 46.475 | 17.603 - 48.919 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||||
| Â Â Â Mean (SD) | 24.090 (20.747) | 6.716 (14.153) | 6.537 (11.610) | 18.861 (13.721) | 47.969 (13.804) | 21.829 (17.106) | 12.772 (17.284) | |
| Â Â Â Range | -1.000 - 70.000 | -1.000 - 68.000 | -1.000 - 72.000 | -1.000 - 62.000 | 1.000 - 70.000 | -1.000 - 68.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||||
| Â Â Â No | 151 (56.8%) | 690 (78.3%) | 989 (87.1%) | 295 (63.0%) | 45 (34.9%) | 118 (53.2%) | 2288 (73.8%) | |
| Â Â Â Yes | 115 (43.2%) | 191 (21.7%) | 146 (12.9%) | 173 (37.0%) | 84 (65.1%) | 104 (46.8%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | |||||||
| Â Â Â No | 89 (33.5%) | 638 (72.4%) | 793 (69.9%) | 101 (21.6%) | 17 (13.2%) | 31 (14.0%) | 1669 (53.8%) | |
| Â Â Â Yes | 177 (66.5%) | 243 (27.6%) | 342 (30.1%) | 367 (78.4%) | 112 (86.8%) | 191 (86.0%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | |||||||
| Â Â Â No | 190 (71.4%) | 797 (90.5%) | 1053 (92.8%) | 368 (78.6%) | 79 (61.2%) | 161 (72.5%) | 2648 (85.4%) | |
| Â Â Â Yes | 76 (28.6%) | 84 (9.5%) | 82 (7.2%) | 100 (21.4%) | 50 (38.8%) | 61 (27.5%) | 453 (14.6%) | |
| dyspenea | < 0.001 | |||||||
| Â Â Â No | 180 (67.7%) | 791 (89.8%) | 1070 (94.3%) | 375 (80.1%) | 59 (45.7%) | 161 (72.5%) | 2636 (85.0%) | |
| Â Â Â Yes | 86 (32.3%) | 90 (10.2%) | 65 (5.7%) | 93 (19.9%) | 70 (54.3%) | 61 (27.5%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | |||||||
| Â Â Â No | 184 (69.2%) | 761 (86.4%) | 1058 (93.2%) | 374 (79.9%) | 66 (51.2%) | 152 (68.5%) | 2595 (83.7%) | |
| Â Â Â Yes | 82 (30.8%) | 120 (13.6%) | 77 (6.8%) | 94 (20.1%) | 63 (48.8%) | 70 (31.5%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.719 (0.118) | 0.771 (0.079) | 0.818 (0.065) | 0.779 (0.081) | 0.745 (0.121) | 0.761 (0.097) | 0.783 (0.088) | |
| Â Â Â Range | 0.267 - 0.940 | 0.230 - 1.028 | 0.259 - 1.180 | 0.371 - 1.006 | 0.295 - 1.590 | 0.340 - 0.995 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||||
| Â Â Â Mean (SD) | 8.389 (8.958) | 5.046 (6.019) | 4.824 (5.522) | 6.628 (6.482) | 9.447 (9.058) | 8.885 (7.899) | 5.948 (6.698) | |
| Â Â Â Range | -26.774 - 49.612 | -6.583 - 55.102 | -12.603 - 77.242 | -20.000 - 53.704 | -4.908 - 67.273 | -12.121 - 46.196 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||||
| Â Â Â Mean (SD) | 2939.591 (2381.793) | 3065.124 (2878.823) | 1811.279 (2376.419) | 1869.865 (2583.100) | 3007.622 (2054.640) | 1784.233 (1891.780) | 2320.957 (2587.337) | |
| Â Â Â Range | 0.000 - 19387.500 | -26261.250 - 38775.000 | -23548.530 - 25908.750 | -6521.250 - 38775.000 | 41.284 - 12925.000 | -2562.590 - 9693.750 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||||
| Â Â Â Mean (SD) | 91.919 (18.669) | 91.671 (13.480) | 106.629 (22.419) | 104.911 (19.551) | 84.576 (16.531) | 104.834 (15.491) | 99.813 (20.194) | |
| Â Â Â Range | 44.453 - 145.795 | 44.914 - 141.333 | 62.015 - 680.093 | 59.402 - 389.709 | 44.477 - 136.837 | 48.917 - 161.534 | 44.453 - 680.093 | |
| kco | < 0.001 | |||||||
| Â Â Â Mean (SD) | 91.912 (18.476) | 90.369 (13.107) | 101.153 (12.651) | 103.256 (13.803) | 89.372 (17.434) | 104.704 (14.140) | 97.378 (15.016) | |
| Â Â Â Range | 28.161 - 142.603 | 47.025 - 141.410 | 43.704 - 139.983 | 65.437 - 144.168 | 40.972 - 139.418 | 60.955 - 149.720 | 28.161 - 149.720 | |
| FeNO | < 0.001 | |||||||
| Â Â Â Mean (SD) | 22.176 (18.802) | 23.723 (19.443) | 19.969 (14.403) | 25.069 (20.897) | 26.625 (26.791) | 30.997 (25.968) | 23.061 (19.138) | |
| Â Â Â Range | 3.600 - 155.000 | 3.500 - 203.000 | 0.000 - 138.000 | 4.600 - 226.000 | 5.000 - 193.000 | 5.000 - 155.000 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.224 (0.206) | 0.199 (0.137) | 0.179 (0.125) | 0.187 (0.128) | 0.208 (0.141) | 0.311 (0.209) | 0.200 (0.149) | |
| Â Â Â Range | 0.010 - 2.300 | 0.000 - 1.000 | 0.000 - 0.900 | 0.000 - 0.900 | 0.020 - 0.800 | 0.040 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 4.197 (1.659) | 3.856 (1.357) | 3.427 (1.149) | 3.750 (1.281) | 4.583 (1.512) | 4.062 (1.418) | 3.757 (1.349) | |
| Â Â Â Range | 1.600 - 12.500 | 1.300 - 11.500 | 0.700 - 9.710 | 1.100 - 12.300 | 2.000 - 10.000 | 1.000 - 9.400 | 0.700 - 12.500 | |
| Lymphocyties | < 0.001 | |||||||
| Â Â Â Mean (SD) | 2.028 (0.859) | 2.021 (0.756) | 1.932 (0.542) | 1.877 (0.558) | 1.946 (0.622) | 1.997 (0.568) | 1.962 (0.649) | |
| Â Â Â Range | 0.300 - 11.200 | 0.400 - 9.400 | 0.300 - 4.000 | 0.400 - 5.000 | 0.900 - 4.000 | 0.700 - 4.100 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.441 (0.165) | 0.467 (0.174) | 0.382 (0.128) | 0.387 (0.124) | 0.445 (0.149) | 0.452 (0.146) | 0.420 (0.152) | |
| Â Â Â Range | 0.200 - 1.100 | 0.200 - 2.400 | 0.100 - 1.000 | 0.200 - 1.000 | 0.200 - 0.900 | 0.200 - 1.100 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.031 (0.046) | 0.023 (0.040) | 0.025 (0.041) | 0.005 (0.020) | 0.030 (0.045) | 0.105 (0.028) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.100 | 0.000 - 0.100 | 0.040 - 0.300 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||||
| Â Â Â No | 122 (45.9%) | 279 (31.7%) | 208 (18.3%) | 157 (33.5%) | 110 (85.3%) | 68 (30.6%) | 944 (30.4%) | |
| Â Â Â Yes | 144 (54.1%) | 602 (68.3%) | 927 (81.7%) | 311 (66.5%) | 19 (14.7%) | 154 (69.4%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | |||||||
| Â Â Â No | 168 (63.2%) | 713 (80.9%) | 573 (50.5%) | 174 (37.2%) | 98 (76.0%) | 111 (50.0%) | 1837 (59.2%) | |
| Â Â Â Yes | 98 (36.8%) | 168 (19.1%) | 562 (49.5%) | 294 (62.8%) | 31 (24.0%) | 111 (50.0%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | |||||||
| Â Â Â No | 240 (90.2%) | 860 (97.6%) | 1117 (98.4%) | 444 (94.9%) | 121 (93.8%) | 202 (91.0%) | 2984 (96.2%) | |
| Â Â Â Yes | 26 (9.8%) | 21 (2.4%) | 18 (1.6%) | 24 (5.1%) | 8 (6.2%) | 20 (9.0%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | |||||||
| Â Â Â No | 141 (53.0%) | 416 (47.2%) | 701 (61.8%) | 282 (60.3%) | 73 (56.6%) | 120 (54.1%) | 1733 (55.9%) | |
| Â Â Â Yes | 125 (47.0%) | 465 (52.8%) | 434 (38.2%) | 186 (39.7%) | 56 (43.4%) | 102 (45.9%) | 1368 (44.1%) | |
| Ever_rhinitis | < 0.001 | |||||||
| Â Â Â No | 68 (25.6%) | 221 (25.1%) | 420 (37.0%) | 115 (24.6%) | 16 (12.4%) | 51 (23.0%) | 891 (28.7%) | |
| Â Â Â Yes | 198 (74.4%) | 660 (74.9%) | 715 (63.0%) | 353 (75.4%) | 113 (87.6%) | 171 (77.0%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | |||||||
| Â Â Â onlys saba or non users | 0 (0.0%) | 807 (91.6%) | 980 (86.3%) | 313 (66.9%) | 108 (83.7%) | 144 (64.9%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 5 (1.9%) | 60 (6.8%) | 117 (10.3%) | 140 (29.9%) | 21 (16.3%) | 66 (29.7%) | 409 (13.2%) | |
| Â Â Â step3 | 47 (17.7%) | 12 (1.4%) | 35 (3.1%) | 15 (3.2%) | 0 (0.0%) | 9 (4.1%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 214 (80.5%) | 2 (0.2%) | 3 (0.3%) | 0 (0.0%) | 0 (0.0%) | 3 (1.4%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | |||||||
| Â Â Â No | 237 (89.1%) | 821 (93.2%) | 1100 (96.9%) | 451 (96.4%) | 113 (87.6%) | 216 (97.3%) | 2938 (94.7%) | |
| Â Â Â Yes | 29 (10.9%) | 60 (6.8%) | 35 (3.1%) | 17 (3.6%) | 16 (12.4%) | 6 (2.7%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | |||||||
| Â Â Â No | 185 (69.5%) | 746 (84.7%) | 1030 (90.7%) | 399 (85.3%) | 95 (73.6%) | 185 (83.3%) | 2640 (85.1%) | |
| Â Â Â Yes | 81 (30.5%) | 135 (15.3%) | 105 (9.3%) | 69 (14.7%) | 34 (26.4%) | 37 (16.7%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | |||||||
| Â Â Â No | 66 (24.8%) | 829 (94.1%) | 1089 (95.9%) | 427 (91.2%) | 108 (83.7%) | 189 (85.1%) | 2708 (87.3%) | |
| Â Â Â Yes | 200 (75.2%) | 52 (5.9%) | 46 (4.1%) | 41 (8.8%) | 21 (16.3%) | 33 (14.9%) | 393 (12.7%) | |
| gina_control | < 0.001 | |||||||
| Â Â Â controlled | 66 (24.8%) | 410 (46.5%) | 622 (54.8%) | 163 (34.8%) | 25 (19.4%) | 58 (26.1%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 137 (51.5%) | 379 (43.0%) | 432 (38.1%) | 249 (53.2%) | 74 (57.4%) | 120 (54.1%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 63 (23.7%) | 92 (10.4%) | 81 (7.1%) | 56 (12.0%) | 30 (23.3%) | 44 (19.8%) | 366 (11.8%) | |
| education | < 0.001 | |||||||
| Â Â Â primary | 124 (46.6%) | 318 (36.1%) | 655 (57.7%) | 261 (55.8%) | 36 (27.9%) | 97 (43.7%) | 1491 (48.1%) | |
| Â Â Â secondary | 102 (38.3%) | 377 (42.8%) | 422 (37.2%) | 178 (38.0%) | 46 (35.7%) | 97 (43.7%) | 1222 (39.4%) | |
| Â Â Â tertiary | 40 (15.0%) | 186 (21.1%) | 58 (5.1%) | 29 (6.2%) | 47 (36.4%) | 28 (12.6%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | |||||||
| Â Â Â No | 147 (55.3%) | 362 (41.1%) | 354 (31.2%) | 293 (62.6%) | 97 (75.2%) | 131 (59.0%) | 1384 (44.6%) | |
| Â Â Â Yes | 119 (44.7%) | 519 (58.9%) | 781 (68.8%) | 175 (37.4%) | 32 (24.8%) | 91 (41.0%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | |||||||
| Â Â Â never smoker | 130 (48.9%) | 326 (37.0%) | 781 (68.8%) | 263 (56.2%) | 56 (43.4%) | 126 (56.8%) | 1682 (54.2%) | |
| Â Â Â former smokers | 117 (44.0%) | 438 (49.7%) | 287 (25.3%) | 172 (36.8%) | 58 (45.0%) | 76 (34.2%) | 1148 (37.0%) | |
| Â Â Â current smoker | 19 (7.1%) | 117 (13.3%) | 67 (5.9%) | 33 (7.1%) | 15 (11.6%) | 20 (9.0%) | 271 (8.7%) | |
| pack_years | < 0.001 | |||||||
| Â Â Â Mean (SD) | 17.410 (18.635) | 18.092 (14.959) | 4.490 (4.865) | 7.582 (7.468) | 27.908 (19.416) | 9.828 (9.466) | 11.286 (13.388) | |
| Â Â Â Range | 0.018 - 111.000 | 0.007 - 104.000 | 0.000 - 35.000 | 0.000 - 43.000 | 0.600 - 112.500 | 0.000 - 55.500 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | |||||||
| Â Â Â No | 93 (35.0%) | 204 (23.2%) | 627 (55.2%) | 147 (31.4%) | 27 (20.9%) | 86 (38.7%) | 1184 (38.2%) | |
| Â Â Â Yes | 173 (65.0%) | 677 (76.8%) | 508 (44.8%) | 321 (68.6%) | 102 (79.1%) | 136 (61.3%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | |||||||
| Â Â Â No | 152 (57.1%) | 321 (36.4%) | 901 (79.4%) | 288 (61.5%) | 49 (38.0%) | 150 (67.6%) | 1861 (60.0%) | |
| Â Â Â Yes | 114 (42.9%) | 560 (63.6%) | 234 (20.6%) | 180 (38.5%) | 80 (62.0%) | 72 (32.4%) | 1240 (40.0%) | |
| household_damage | < 0.001 | |||||||
| Â Â Â No | 239 (89.8%) | 825 (93.6%) | 950 (83.7%) | 404 (86.3%) | 119 (92.2%) | 195 (87.8%) | 2732 (88.1%) | |
| Â Â Â Yes | 27 (10.2%) | 56 (6.4%) | 185 (16.3%) | 64 (13.7%) | 10 (7.8%) | 27 (12.2%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 87 (32.7%) | 797 (90.5%) | 942 (83.0%) | 30 (6.4%) | 23 (17.8%) | 20 (9.0%) | 1899 (61.2%) | |
| Â Â Â Yes | 179 (67.3%) | 84 (9.5%) | 193 (17.0%) | 438 (93.6%) | 106 (82.2%) | 202 (91.0%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 83 (31.2%) | 797 (90.5%) | 975 (85.9%) | 31 (6.6%) | 23 (17.8%) | 18 (8.1%) | 1927 (62.1%) | |
| Â Â Â Yes | 183 (68.8%) | 84 (9.5%) | 160 (14.1%) | 437 (93.4%) | 106 (82.2%) | 204 (91.9%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 201 (75.6%) | 842 (95.6%) | 1055 (93.0%) | 223 (47.6%) | 96 (74.4%) | 121 (54.5%) | 2538 (81.8%) | |
| Â Â Â Yes | 65 (24.4%) | 39 (4.4%) | 80 (7.0%) | 245 (52.4%) | 33 (25.6%) | 101 (45.5%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 225 (84.6%) | 869 (98.6%) | 1111 (97.9%) | 336 (71.8%) | 112 (86.8%) | 163 (73.4%) | 2816 (90.8%) | |
| Â Â Â Yes | 41 (15.4%) | 12 (1.4%) | 24 (2.1%) | 132 (28.2%) | 17 (13.2%) | 59 (26.6%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 177 (66.5%) | 863 (98.0%) | 1124 (99.0%) | 163 (34.8%) | 76 (58.9%) | 86 (38.7%) | 2489 (80.3%) | |
| Â Â Â Yes | 89 (33.5%) | 18 (2.0%) | 11 (1.0%) | 305 (65.2%) | 53 (41.1%) | 136 (61.3%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 246 (92.5%) | 878 (99.7%) | 1129 (99.5%) | 401 (85.7%) | 106 (82.2%) | 176 (79.3%) | 2936 (94.7%) | |
| Â Â Â Yes | 20 (7.5%) | 3 (0.3%) | 6 (0.5%) | 67 (14.3%) | 23 (17.8%) | 46 (20.7%) | 165 (5.3%) | |
| XCOPD | < 0.001 | |||||||
| Â Â Â No | 192 (72.2%) | 820 (93.1%) | 1111 (97.9%) | 419 (89.5%) | 93 (72.1%) | 192 (86.5%) | 2827 (91.2%) | |
| Â Â Â Yes | 74 (27.8%) | 61 (6.9%) | 24 (2.1%) | 49 (10.5%) | 36 (27.9%) | 30 (13.5%) | 274 (8.8%) |
1.1.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## gina_steps 0.000000e+00 15
## exertion_triggered_asthma 0.000000e+00 5
## infection_triggered_asthma 0.000000e+00 5
## weather_triggered_asthma 4.766057e-289 5
## severe_asthma 3.791249e-227 5
## Breathlessness 9.584809e-151 5
## allergen_triggered_asthma 1.485091e-148 5
## irritant_triggered_asthma 7.026520e-91 5
## smoking_exposure_at_work 2.491500e-87 5
## dyspenea 8.071688e-73 5
## Cough 1.659705e-69 5
## familial_allergy 1.989879e-68 5
## emotion_triggered_asthma 1.803248e-66 5
## spt_any 1.545222e-61 5
## Chronic_productive_cough 6.451591e-55 5
## XCOPD 1.608214e-52 5
## smoking_exposure_at_home 3.714230e-52 5
## education 1.004803e-47 10
## urbanization_level 2.663487e-47 5
## Recurrent_wheeze 9.235255e-45 5
## smoking_status 1.739600e-41 10
## gina_control 2.002237e-39 10
## Emergency_last_year 1.233815e-18 5
## Gender 2.710162e-15 5
## Ever_rhinitis 1.430648e-13 5
## Drug_induced_dyspnea 3.818094e-13 5
## household_damage 8.260654e-10 5
## Hosptalization_last_year 1.009475e-09 5
## nasal_plyposis 4.313040e-09 5
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## gina_steps=step4 or 5 96.396396 80.451128 7.158981 2.161967e-267
## severe_asthma=Yes 50.890585 75.187970 12.673331 6.712107e-143
## infection_triggered_asthma=Yes 15.587734 68.796992 37.858755 1.244776e-26
## exertion_triggered_asthma=Yes 14.891847 67.293233 38.761690 8.374717e-23
## XCOPD=Yes 27.007299 27.819549 8.835859 9.813619e-22
## gina_steps=step3 39.830508 17.669173 3.805224 1.782545e-21
## dyspenea=Yes 18.494624 32.330827 14.995163 7.225598e-14
## Breathlessness=Yes 12.360335 66.541353 46.178652 3.032662e-12
## Emergency_last_year=Yes 17.570499 30.451128 14.866172 1.066291e-11
## Cough=Yes 14.145141 43.233083 26.217349 3.159892e-10
## Chronic_productive_cough=Yes 16.205534 30.827068 16.317317 6.565051e-10
## Recurrent_wheeze=Yes 16.777042 28.571429 14.608191 6.815996e-10
## gina_control=uncontrolled 17.213115 23.684211 11.802644 1.212571e-08
## spt_any=No 12.923729 45.864662 30.441793 3.205390e-08
## weather_triggered_asthma=Yes 14.542484 33.458647 19.735569 3.216530e-08
## Drug_induced_dyspnea=Yes 22.222222 9.774436 3.772976 4.207334e-06
## Hosptalization_last_year=Yes 17.791411 10.902256 5.256369 1.152336e-04
## urbanization_level=No 10.621387 55.263158 44.630764 2.842742e-04
## irritant_triggered_asthma=Yes 14.385965 15.413534 9.190584 6.330357e-04
## allergen_triggered_asthma=Yes 11.545293 24.436090 18.155434 7.205939e-03
## smoking_status=former smokers 10.191638 43.984962 37.020316 1.489282e-02
## gina_control=partially controlled 9.849029 51.503759 44.856498 2.320737e-02
## allergen_triggered_asthma=No 7.919622 75.563910 81.844566 7.205939e-03
## irritant_triggered_asthma=No 7.990057 84.586466 90.809416 6.330357e-04
## urbanization_level=Yes 6.930693 44.736842 55.369236 2.842742e-04
## Hosptalization_last_year=No 8.066712 89.097744 94.743631 1.152336e-04
## Drug_induced_dyspnea=No 8.042895 90.225564 96.227024 4.207334e-06
## weather_triggered_asthma=No 7.111290 66.541353 80.264431 3.216530e-08
## spt_any=Yes 6.675939 54.135338 69.558207 3.205390e-08
## Recurrent_wheeze=No 7.175227 71.428571 85.391809 6.815996e-10
## Chronic_productive_cough=No 7.090559 69.172932 83.682683 6.565051e-10
## Cough=No 6.599650 56.766917 73.782651 3.159892e-10
## gina_control=controlled 4.910714 24.812030 43.340858 6.146898e-11
## gina_steps=step 1 or 2 1.222494 1.879699 13.189294 1.282595e-11
## Emergency_last_year=No 7.007576 69.548872 85.133828 1.066291e-11
## Breathlessness=No 5.332534 33.458647 53.821348 3.032662e-12
## dyspenea=No 6.828528 67.669173 85.004837 7.225598e-14
## XCOPD=No 6.791652 72.180451 91.164141 9.813619e-22
## exertion_triggered_asthma=No 4.581359 32.706767 61.238310 8.374717e-23
## infection_triggered_asthma=No 4.307213 31.203008 62.141245 1.244776e-26
## severe_asthma=No 2.437223 24.812030 87.326669 6.712107e-143
## gina_steps=onlys saba or non users 0.000000 0.000000 75.846501 3.606965e-183
## v.test
## gina_steps=step4 or 5 34.935343
## severe_asthma=Yes 25.451980
## infection_triggered_asthma=Yes 10.681328
## exertion_triggered_asthma=Yes 9.829845
## XCOPD=Yes 9.578845
## gina_steps=step3 9.516998
## dyspenea=Yes 7.483705
## Breathlessness=Yes 6.976202
## Emergency_last_year=Yes 6.797258
## Cough=Yes 6.290724
## Chronic_productive_cough=Yes 6.176230
## Recurrent_wheeze=Yes 6.170301
## gina_control=uncontrolled 5.697949
## spt_any=No 5.529831
## weather_triggered_asthma=Yes 5.529223
## Drug_induced_dyspnea=Yes 4.600868
## Hosptalization_last_year=Yes 3.856051
## urbanization_level=No 3.629224
## irritant_triggered_asthma=Yes 3.417050
## allergen_triggered_asthma=Yes 2.687174
## smoking_status=former smokers 2.434975
## gina_control=partially controlled 2.270004
## allergen_triggered_asthma=No -2.687174
## irritant_triggered_asthma=No -3.417050
## urbanization_level=Yes -3.629224
## Hosptalization_last_year=No -3.856051
## Drug_induced_dyspnea=No -4.600868
## weather_triggered_asthma=No -5.529223
## spt_any=Yes -5.529831
## Recurrent_wheeze=No -6.170301
## Chronic_productive_cough=No -6.176230
## Cough=No -6.290724
## gina_control=controlled -6.540121
## gina_steps=step 1 or 2 -6.770589
## Emergency_last_year=No -6.797258
## Breathlessness=No -6.976202
## dyspenea=No -7.483705
## XCOPD=No -9.578845
## exertion_triggered_asthma=No -9.829845
## infection_triggered_asthma=No -10.681328
## severe_asthma=No -25.451980
## gina_steps=onlys saba or non users -28.861764
##
## $`1`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 41.9694576 90.4653802 61.238310
## infection_triggered_asthma=No 41.3596264 90.4653802 62.141245
## weather_triggered_asthma=No 34.6725593 97.9568672 80.264431
## smoking_exposure_at_work=Yes 45.1612903 63.5641317 39.987101
## familial_allergy=No 38.8132825 80.9307605 59.238955
## gina_steps=onlys saba or non users 34.3112245 91.6004540 75.846501
## allergen_triggered_asthma=No 33.1757289 95.5732123 81.844566
## Breathlessness=No 38.2264829 72.4177072 53.821348
## smoking_exposure_at_home=Yes 35.3155973 76.8444949 61.818768
## irritant_triggered_asthma=No 30.8593750 98.6379115 90.809416
## emotion_triggered_asthma=No 29.9046322 99.6594779 94.679136
## smoking_status=former smokers 38.1533101 49.7162316 37.020316
## education=tertiary 47.9381443 21.1123723 12.512093
## severe_asthma=No 30.6129985 94.0976163 87.326669
## Gender=No 35.3823088 53.5754824 43.018381
## household_damage=No 30.1976574 93.6435868 88.100613
## nasal_plyposis=Yes 33.9912281 52.7809308 44.114802
## smoking_status=current smoker 43.1734317 13.2803632 8.739116
## Recurrent_wheeze=No 30.0981873 90.4653802 85.391809
## dyspenea=No 30.0075873 89.7843360 85.004837
## Cough=No 30.1573427 78.3200908 73.782651
## Ever_rhinitis=Yes 29.8642534 74.9148695 71.267333
## Drug_induced_dyspnea=No 28.8203753 97.6163451 96.227024
## Chronic_productive_cough=No 29.3256262 86.3791146 83.682683
## urbanization_level=Yes 30.2271404 58.9103292 55.369236
## education=secondary 30.8510638 42.7922815 39.406643
## XCOPD=No 29.0060134 93.0760499 91.164141
## Hosptalization_last_year=Yes 36.8098160 6.8104427 5.256369
## gina_control=controlled 30.5059524 46.5380250 43.340858
## Hosptalization_last_year=No 27.9441797 93.1895573 94.743631
## XCOPD=Yes 22.2627737 6.9239501 8.835859
## urbanization_level=No 26.1560694 41.0896708 44.630764
## Chronic_productive_cough=Yes 23.7154150 13.6208854 16.317317
## Drug_induced_dyspnea=Yes 17.9487179 2.3836549 3.772976
## Ever_rhinitis=No 24.8035915 25.0851305 28.732667
## Cough=Yes 23.4932349 21.6799092 26.217349
## dyspenea=Yes 19.3548387 10.2156640 14.995163
## gina_steps=step3 10.1694915 1.3620885 3.805224
## Recurrent_wheeze=Yes 18.5430464 9.5346198 14.608191
## nasal_plyposis=No 24.0046163 47.2190692 55.885198
## household_damage=Yes 15.1761518 6.3564132 11.899387
## gina_steps=step 1 or 2 14.6699267 6.8104427 13.189294
## Gender=Yes 23.1465761 46.4245176 56.981619
## severe_asthma=Yes 13.2315522 5.9023837 12.673331
## education=primary 21.3279678 36.0953462 48.081264
## emotion_triggered_asthma=Yes 1.8181818 0.3405221 5.320864
## irritant_triggered_asthma=Yes 4.2105263 1.3620885 9.190584
## smoking_exposure_at_home=No 17.2297297 23.1555051 38.181232
## gina_steps=step4 or 5 0.9009009 0.2270148 7.158981
## smoking_status=never smoker 19.3816885 37.0034052 54.240568
## Breathlessness=Yes 16.9692737 27.5822928 46.178652
## allergen_triggered_asthma=Yes 6.9271758 4.4267877 18.155434
## familial_allergy=Yes 13.2911392 19.0692395 40.761045
## smoking_exposure_at_work=No 17.2487910 36.4358683 60.012899
## weather_triggered_asthma=Yes 2.9411765 2.0431328 19.735569
## infection_triggered_asthma=Yes 7.1550256 9.5346198 37.858755
## exertion_triggered_asthma=Yes 6.9883527 9.5346198 38.761690
## p.value v.test
## exertion_triggered_asthma=No 2.052603e-112 22.531213
## infection_triggered_asthma=No 9.483726e-107 21.945869
## weather_triggered_asthma=No 1.763193e-72 18.005525
## smoking_exposure_at_work=Yes 2.681682e-63 16.794408
## familial_allergy=No 1.176859e-57 16.005120
## gina_steps=onlys saba or non users 8.974767e-44 13.875036
## allergen_triggered_asthma=No 1.552959e-43 13.835664
## Breathlessness=No 3.006857e-40 13.280424
## smoking_exposure_at_home=Yes 1.288165e-28 11.097629
## irritant_triggered_asthma=No 6.504809e-28 10.951928
## emotion_triggered_asthma=No 1.153436e-20 9.320913
## smoking_status=former smokers 6.693027e-20 9.132508
## education=tertiary 2.307166e-18 8.741166
## severe_asthma=No 3.150334e-14 7.591988
## Gender=No 9.217340e-14 7.451659
## household_damage=No 2.670492e-10 6.316792
## nasal_plyposis=Yes 1.028780e-09 6.104880
## smoking_status=current smoker 5.458983e-08 5.435674
## Recurrent_wheeze=No 1.921558e-07 5.206770
## dyspenea=No 1.337142e-06 4.834152
## Cough=No 2.543314e-04 3.657859
## Ever_rhinitis=Yes 4.431737e-03 2.845675
## Drug_induced_dyspnea=No 8.301305e-03 2.639563
## Chronic_productive_cough=No 9.647021e-03 2.588231
## urbanization_level=Yes 1.238982e-02 2.500843
## education=secondary 1.538547e-02 2.423176
## XCOPD=No 1.636579e-02 2.400654
## Hosptalization_last_year=Yes 1.702226e-02 2.386227
## gina_control=controlled 2.389404e-02 2.258829
## Hosptalization_last_year=No 1.702226e-02 -2.386227
## XCOPD=Yes 1.636579e-02 -2.400654
## urbanization_level=No 1.238982e-02 -2.500843
## Chronic_productive_cough=Yes 9.647021e-03 -2.588231
## Drug_induced_dyspnea=Yes 8.301305e-03 -2.639563
## Ever_rhinitis=No 4.431737e-03 -2.845675
## Cough=Yes 2.543314e-04 -3.657859
## dyspenea=Yes 1.337142e-06 -4.834152
## gina_steps=step3 1.153070e-06 -4.863536
## Recurrent_wheeze=Yes 1.921558e-07 -5.206770
## nasal_plyposis=No 1.028780e-09 -6.104880
## household_damage=Yes 2.670492e-10 -6.316792
## gina_steps=step 1 or 2 3.136736e-12 -6.971458
## Gender=Yes 9.217340e-14 -7.451659
## severe_asthma=Yes 3.150334e-14 -7.591988
## education=primary 2.771706e-17 -8.455804
## emotion_triggered_asthma=Yes 1.153436e-20 -9.320913
## irritant_triggered_asthma=Yes 6.504809e-28 -10.951928
## smoking_exposure_at_home=No 1.288165e-28 -11.097629
## gina_steps=step4 or 5 1.060142e-30 -11.518852
## smoking_status=never smoker 5.819022e-34 -12.148833
## Breathlessness=Yes 3.006857e-40 -13.280424
## allergen_triggered_asthma=Yes 1.552959e-43 -13.835664
## familial_allergy=Yes 1.176859e-57 -16.005120
## smoking_exposure_at_work=No 2.681682e-63 -16.794408
## weather_triggered_asthma=Yes 1.763193e-72 -18.005525
## infection_triggered_asthma=Yes 9.483726e-107 -21.945869
## exertion_triggered_asthma=Yes 2.052603e-112 -22.531213
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## weather_triggered_asthma=No 45.158698 99.0308370 80.264431 5.173074e-118
## infection_triggered_asthma=No 50.596783 85.9030837 62.141245 1.755219e-103
## exertion_triggered_asthma=No 49.605055 82.9955947 61.238310 7.106772e-85
## smoking_exposure_at_work=No 48.414831 79.3832599 60.012899 7.536365e-66
## smoking_exposure_at_home=No 52.956081 55.2422907 38.181232 1.466189e-49
## Breathlessness=No 47.513481 69.8678414 53.821348 4.826107e-43
## Cough=No 43.225524 87.1365639 73.782651 1.422789e-40
## allergen_triggered_asthma=No 41.568164 92.9515419 81.844566 3.865763e-38
## smoking_status=never smoker 46.432818 68.8105727 54.240568 9.416948e-36
## severe_asthma=No 40.214180 95.9471366 87.326669 3.813426e-32
## dyspenea=No 40.591806 94.2731278 85.004837 1.779893e-31
## urbanization_level=Yes 45.486313 68.8105727 55.369236 8.497165e-31
## Chronic_productive_cough=No 40.770713 93.2158590 83.682683 9.778720e-31
## irritant_triggered_asthma=No 39.453125 97.8854626 90.809416 3.741989e-30
## spt_any=Yes 42.976356 81.6740088 69.558207 4.016019e-30
## XCOPD=No 39.299611 97.8854626 91.164141 3.479488e-28
## gina_steps=onlys saba or non users 41.666667 86.3436123 75.846501 1.045894e-26
## emotion_triggered_asthma=No 38.453678 99.4713656 94.679136 2.768577e-25
## gina_control=controlled 46.279762 54.8017621 43.340858 1.509686e-22
## Recurrent_wheeze=No 39.765861 92.7753304 85.391809 2.398573e-20
## education=primary 43.930248 57.7092511 48.081264 3.396519e-16
## Ever_rhinitis=No 47.138047 37.0044053 28.732667 1.815310e-14
## familial_allergy=Yes 44.462025 49.5154185 40.761045 5.739593e-14
## Emergency_last_year=No 39.015152 90.7488987 85.133828 6.412423e-12
## household_damage=Yes 50.135501 16.2995595 11.899387 1.584299e-08
## Drug_induced_dyspnea=No 37.432976 98.4140969 96.227024 2.799134e-07
## nasal_plyposis=No 40.450087 61.7621145 55.885198 5.206032e-07
## Hosptalization_last_year=No 37.440436 96.9162996 94.743631 2.077374e-05
## gina_steps=step 1 or 2 28.606357 10.3083700 13.189294 2.629395e-04
## Hosptalization_last_year=Yes 21.472393 3.0837004 5.256369 2.077374e-05
## smoking_status=current smoker 24.723247 5.9030837 8.739116 1.365974e-05
## nasal_plyposis=Yes 31.725146 38.2378855 44.114802 5.206032e-07
## Drug_induced_dyspnea=Yes 15.384615 1.5859031 3.772976 2.799134e-07
## household_damage=No 34.773060 83.7004405 88.100613 1.584299e-08
## gina_control=partially controlled 31.056794 38.0616740 44.856498 6.841593e-09
## gina_control=uncontrolled 22.131148 7.1365639 11.802644 2.745286e-10
## Emergency_last_year=Yes 22.776573 9.2511013 14.866172 6.412423e-12
## familial_allergy=No 31.192161 50.4845815 59.238955 5.739593e-14
## Ever_rhinitis=Yes 32.352941 62.9955947 71.267333 1.815310e-14
## Recurrent_wheeze=Yes 18.101545 7.2246696 14.608191 2.398573e-20
## education=tertiary 14.948454 5.1101322 12.512093 1.124701e-23
## emotion_triggered_asthma=Yes 3.636364 0.5286344 5.320864 2.768577e-25
## smoking_status=former smokers 25.000000 25.2863436 37.020316 1.956415e-25
## XCOPD=Yes 8.759124 2.1145374 8.835859 3.479488e-28
## spt_any=No 22.033898 18.3259912 30.441793 4.016019e-30
## irritant_triggered_asthma=Yes 8.421053 2.1145374 9.190584 3.741989e-30
## Chronic_productive_cough=Yes 15.217391 6.7841410 16.317317 9.778720e-31
## urbanization_level=No 25.578035 31.1894273 44.630764 8.497165e-31
## dyspenea=Yes 13.978495 5.7268722 14.995163 1.779893e-31
## severe_asthma=Yes 11.704835 4.0528634 12.673331 3.813426e-32
## allergen_triggered_asthma=Yes 14.209591 7.0484581 18.155434 3.865763e-38
## Cough=Yes 17.958180 12.8634361 26.217349 1.422789e-40
## gina_steps=step4 or 5 1.351351 0.2643172 7.158981 4.556662e-41
## Breathlessness=Yes 23.882682 30.1321586 46.178652 4.826107e-43
## smoking_exposure_at_home=Yes 26.499739 44.7577093 61.818768 1.466189e-49
## smoking_exposure_at_work=Yes 18.870968 20.6167401 39.987101 7.536365e-66
## exertion_triggered_asthma=Yes 16.056572 17.0044053 38.761690 7.106772e-85
## infection_triggered_asthma=Yes 13.628620 14.0969163 37.858755 1.755219e-103
## weather_triggered_asthma=Yes 1.797386 0.9691630 19.735569 5.173074e-118
## v.test
## weather_triggered_asthma=No 23.095207
## infection_triggered_asthma=No 21.601065
## exertion_triggered_asthma=No 19.522230
## smoking_exposure_at_work=No 17.139447
## smoking_exposure_at_home=No 14.799937
## Breathlessness=No 13.753893
## Cough=No 13.336338
## allergen_triggered_asthma=No 12.911718
## smoking_status=never smoker 12.481522
## severe_asthma=No 11.801956
## dyspenea=No 11.671626
## urbanization_level=Yes 11.537903
## Chronic_productive_cough=No 11.525811
## irritant_triggered_asthma=No 11.409658
## spt_any=Yes 11.403508
## XCOPD=No 11.008447
## gina_steps=onlys saba or non users 10.697475
## emotion_triggered_asthma=No 10.389480
## gina_control=controlled 9.770324
## Recurrent_wheeze=No 9.242921
## education=primary 8.158343
## Ever_rhinitis=No 7.663077
## familial_allergy=Yes 7.513890
## Emergency_last_year=No 6.870173
## household_damage=Yes 5.652175
## Drug_induced_dyspnea=No 5.136493
## nasal_plyposis=No 5.018560
## Hosptalization_last_year=No 4.256408
## gina_steps=step 1 or 2 -3.649316
## Hosptalization_last_year=Yes -4.256408
## smoking_status=current smoker -4.349260
## nasal_plyposis=Yes -5.018560
## Drug_induced_dyspnea=Yes -5.136493
## household_damage=No -5.652175
## gina_control=partially controlled -5.794767
## gina_control=uncontrolled -6.312520
## Emergency_last_year=Yes -6.870173
## familial_allergy=No -7.513890
## Ever_rhinitis=Yes -7.663077
## Recurrent_wheeze=Yes -9.242921
## education=tertiary -10.030041
## emotion_triggered_asthma=Yes -10.389480
## smoking_status=former smokers -10.422547
## XCOPD=Yes -11.008447
## spt_any=No -11.403508
## irritant_triggered_asthma=Yes -11.409658
## Chronic_productive_cough=Yes -11.525811
## urbanization_level=No -11.537903
## dyspenea=Yes -11.671626
## severe_asthma=Yes -11.801956
## allergen_triggered_asthma=Yes -12.911718
## Cough=Yes -13.336338
## gina_steps=step4 or 5 -13.420977
## Breathlessness=Yes -13.753893
## smoking_exposure_at_home=Yes -14.799937
## smoking_exposure_at_work=Yes -17.139447
## exertion_triggered_asthma=Yes -19.522230
## infection_triggered_asthma=Yes -21.601065
## weather_triggered_asthma=Yes -23.095207
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 37.223169 93.376068 37.858755 1.166459e-167
## exertion_triggered_asthma=Yes 36.439268 93.589744 38.761690 8.034173e-164
## weather_triggered_asthma=Yes 49.836601 65.170940 19.735569 9.265579e-128
## allergen_triggered_asthma=Yes 43.516874 52.350427 18.155434 5.889553e-78
## Breathlessness=Yes 25.628492 78.418803 46.178652 8.375903e-54
## irritant_triggered_asthma=Yes 46.315789 28.205128 9.190584 9.618531e-41
## gina_steps=step 1 or 2 34.229829 29.914530 13.189294 7.657696e-26
## familial_allergy=Yes 23.259494 62.820513 40.761045 1.676097e-25
## urbanization_level=No 21.170520 62.606838 44.630764 2.500992e-17
## emotion_triggered_asthma=Yes 40.606061 14.316239 5.320864 2.452799e-16
## Gender=Yes 18.222977 68.803419 56.981619 1.394317e-08
## Cough=Yes 21.279213 36.965812 26.217349 2.578073e-08
## Recurrent_wheeze=Yes 22.075055 21.367521 14.608191 1.705779e-05
## gina_control=partially controlled 17.900791 53.205128 44.856498 8.637823e-05
## education=primary 17.505030 55.769231 48.081264 3.083267e-04
## smoking_exposure_at_home=Yes 16.744914 68.589744 61.818768 9.655856e-04
## dyspenea=Yes 20.000000 19.871795 14.995163 1.880633e-03
## severe_asthma=No 15.768095 91.239316 87.326669 4.306894e-03
## Chronic_productive_cough=Yes 18.577075 20.085470 16.317317 1.907010e-02
## Ever_rhinitis=Yes 15.972851 75.427350 71.267333 2.948684e-02
## nasal_plyposis=No 16.272360 60.256410 55.885198 3.848474e-02
## nasal_plyposis=Yes 13.596491 39.743590 44.114802 3.848474e-02
## Ever_rhinitis=No 12.906846 24.572650 28.732667 2.948684e-02
## Chronic_productive_cough=No 14.412331 79.914530 83.682683 1.907010e-02
## severe_asthma=Yes 10.432570 8.760684 12.673331 4.306894e-03
## dyspenea=No 14.226100 80.128205 85.004837 1.880633e-03
## smoking_exposure_at_home=No 12.415541 31.410256 38.181232 9.655856e-04
## gina_control=controlled 12.127976 34.829060 43.340858 4.903796e-05
## Recurrent_wheeze=No 13.897281 78.632479 85.391809 1.705779e-05
## gina_steps=onlys saba or non users 13.307823 66.880342 75.846501 1.790834e-06
## education=tertiary 7.474227 6.196581 12.512093 1.566980e-06
## Cough=No 12.893357 63.034188 73.782651 2.578073e-08
## Gender=No 10.944528 31.196581 43.018381 1.394317e-08
## emotion_triggered_asthma=No 13.658038 85.683761 94.679136 2.452799e-16
## gina_steps=step4 or 5 0.000000 0.000000 7.158981 3.823053e-17
## urbanization_level=Yes 10.192196 37.393162 55.369236 2.500992e-17
## familial_allergy=No 9.471965 37.179487 59.238955 1.676097e-25
## irritant_triggered_asthma=No 11.931818 71.794872 90.809416 9.618531e-41
## Breathlessness=No 6.051528 21.581197 53.821348 8.375903e-54
## allergen_triggered_asthma=No 8.786446 47.649573 81.844566 5.889553e-78
## weather_triggered_asthma=No 6.548815 34.829060 80.264431 9.265579e-128
## exertion_triggered_asthma=No 1.579779 6.410256 61.238310 8.034173e-164
## infection_triggered_asthma=No 1.608718 6.623932 62.141245 1.166459e-167
## v.test
## infection_triggered_asthma=Yes 27.598293
## exertion_triggered_asthma=Yes 27.276623
## weather_triggered_asthma=Yes 24.045670
## allergen_triggered_asthma=Yes 18.690735
## Breathlessness=Yes 15.443259
## irritant_triggered_asthma=Yes 13.365501
## gina_steps=step 1 or 2 10.511365
## familial_allergy=Yes 10.437242
## urbanization_level=No 8.467787
## emotion_triggered_asthma=Yes 8.197577
## Gender=Yes 5.674085
## Cough=Yes 5.567914
## Recurrent_wheeze=Yes 4.300286
## gina_control=partially controlled 3.925978
## education=primary 3.608202
## smoking_exposure_at_home=Yes 3.300367
## dyspenea=Yes 3.108463
## severe_asthma=No 2.854763
## Chronic_productive_cough=Yes 2.344158
## Ever_rhinitis=Yes 2.176916
## nasal_plyposis=No 2.069654
## nasal_plyposis=Yes -2.069654
## Ever_rhinitis=No -2.176916
## Chronic_productive_cough=No -2.344158
## severe_asthma=Yes -2.854763
## dyspenea=No -3.108463
## smoking_exposure_at_home=No -3.300367
## gina_control=controlled -4.060165
## Recurrent_wheeze=No -4.300286
## gina_steps=onlys saba or non users -4.775700
## education=tertiary -4.802499
## Cough=No -5.567914
## Gender=No -5.674085
## emotion_triggered_asthma=No -8.197577
## gina_steps=step4 or 5 -8.418202
## urbanization_level=Yes -8.467787
## familial_allergy=No -10.437242
## irritant_triggered_asthma=No -13.365501
## Breathlessness=No -15.443259
## allergen_triggered_asthma=No -18.690735
## weather_triggered_asthma=No -24.045670
## exertion_triggered_asthma=No -27.276623
## infection_triggered_asthma=No -27.598293
##
## $`4`
## Cla/Mod Mod/Cla Global p.value
## spt_any=No 11.652542 85.27132 30.441793 8.347855e-40
## dyspenea=Yes 15.053763 54.26357 14.995163 1.787125e-26
## infection_triggered_asthma=Yes 9.028961 82.17054 37.858755 7.158636e-26
## exertion_triggered_asthma=Yes 8.818636 82.17054 38.761690 7.049769e-25
## Breathlessness=Yes 7.821229 86.82171 46.178652 9.970351e-23
## Cough=Yes 10.332103 65.11628 26.217349 3.324522e-21
## Chronic_productive_cough=Yes 12.450593 48.83721 16.317317 1.487824e-18
## urbanization_level=No 7.008671 75.19380 44.630764 7.256183e-13
## education=tertiary 12.113402 36.43411 12.512093 9.747791e-13
## Recurrent_wheeze=Yes 11.037528 38.75969 14.608191 5.359591e-12
## XCOPD=Yes 13.138686 27.90698 8.835859 1.111250e-10
## weather_triggered_asthma=Yes 8.660131 41.08527 19.735569 1.362927e-08
## emotion_triggered_asthma=Yes 13.939394 17.82946 5.320864 1.733953e-07
## smoking_exposure_at_work=Yes 6.451613 62.01550 39.987101 2.863589e-07
## Ever_rhinitis=Yes 5.113122 87.59690 71.267333 7.578981e-06
## smoking_exposure_at_home=Yes 5.320814 79.06977 61.818768 2.006074e-05
## familial_allergy=No 5.334785 75.96899 59.238955 5.070768e-05
## gina_control=uncontrolled 8.196721 23.25581 11.802644 1.943594e-04
## Emergency_last_year=Yes 7.375271 26.35659 14.866172 5.325753e-04
## Hosptalization_last_year=Yes 9.815951 12.40310 5.256369 1.275059e-03
## gina_control=partially controlled 5.319914 57.36434 44.856498 3.758364e-03
## Gender=Yes 4.923599 67.44186 56.981619 1.357349e-02
## gina_steps=onlys saba or non users 4.591837 83.72093 75.846501 2.832831e-02
## allergen_triggered_asthma=Yes 5.861456 25.58140 18.155434 3.175134e-02
## allergen_triggered_asthma=No 3.782506 74.41860 81.844566 3.175134e-02
## Gender=No 3.148426 32.55814 43.018381 1.357349e-02
## smoking_status=never smoker 3.329370 43.41085 54.240568 1.216448e-02
## gina_steps=step3 0.000000 0.00000 3.805224 6.018283e-03
## Hosptalization_last_year=No 3.846154 87.59690 94.743631 1.275059e-03
## Emergency_last_year=No 3.598485 73.64341 85.133828 5.325753e-04
## gina_steps=step4 or 5 0.000000 0.00000 7.158981 5.580135e-05
## familial_allergy=Yes 2.452532 24.03101 40.761045 5.070768e-05
## smoking_exposure_at_home=No 2.280405 20.93023 38.181232 2.006074e-05
## Ever_rhinitis=No 1.795735 12.40310 28.732667 7.578981e-06
## education=primary 2.414487 27.90698 48.081264 2.028889e-06
## smoking_exposure_at_work=No 2.632993 37.98450 60.012899 2.863589e-07
## emotion_triggered_asthma=No 3.610354 82.17054 94.679136 1.733953e-07
## weather_triggered_asthma=No 3.053435 58.91473 80.264431 1.362927e-08
## gina_control=controlled 1.860119 19.37984 43.340858 5.515251e-09
## XCOPD=No 3.289706 72.09302 91.164141 1.111250e-10
## Recurrent_wheeze=No 2.983384 61.24031 85.391809 5.359591e-12
## urbanization_level=Yes 1.863716 24.80620 55.369236 7.256183e-13
## Chronic_productive_cough=No 2.543353 51.16279 83.682683 1.487824e-18
## Cough=No 1.966783 34.88372 73.782651 3.324522e-21
## Breathlessness=No 1.018574 13.17829 53.821348 9.970351e-23
## exertion_triggered_asthma=No 1.211164 17.82946 61.238310 7.049769e-25
## infection_triggered_asthma=No 1.193565 17.82946 62.141245 7.158636e-26
## dyspenea=No 2.238240 45.73643 85.004837 1.787125e-26
## spt_any=Yes 0.880853 14.72868 69.558207 8.347855e-40
## v.test
## spt_any=No 13.203746
## dyspenea=Yes 10.647707
## infection_triggered_asthma=Yes 10.517718
## exertion_triggered_asthma=Yes 10.299950
## Breathlessness=Yes 9.812267
## Cough=Yes 9.451989
## Chronic_productive_cough=Yes 8.790586
## urbanization_level=No 7.174519
## education=tertiary 7.134022
## Recurrent_wheeze=Yes 6.895711
## XCOPD=Yes 6.450986
## weather_triggered_asthma=Yes 5.677982
## emotion_triggered_asthma=Yes 5.225809
## smoking_exposure_at_work=Yes 5.132211
## Ever_rhinitis=Yes 4.476745
## smoking_exposure_at_home=Yes 4.264214
## familial_allergy=No 4.052341
## gina_control=uncontrolled 3.726237
## Emergency_last_year=Yes 3.463814
## Hosptalization_last_year=Yes 3.221535
## gina_control=partially controlled 2.897761
## Gender=Yes 2.468357
## gina_steps=onlys saba or non users 2.192710
## allergen_triggered_asthma=Yes 2.147527
## allergen_triggered_asthma=No -2.147527
## Gender=No -2.468357
## smoking_status=never smoker -2.507337
## gina_steps=step3 -2.746784
## Hosptalization_last_year=No -3.221535
## Emergency_last_year=No -3.463814
## gina_steps=step4 or 5 -4.029897
## familial_allergy=Yes -4.052341
## smoking_exposure_at_home=No -4.264214
## Ever_rhinitis=No -4.476745
## education=primary -4.750525
## smoking_exposure_at_work=No -5.132211
## emotion_triggered_asthma=No -5.225809
## weather_triggered_asthma=No -5.677982
## gina_control=controlled -5.830830
## XCOPD=No -6.450986
## Recurrent_wheeze=No -6.895711
## urbanization_level=Yes -7.174519
## Chronic_productive_cough=No -8.790586
## Cough=No -9.451989
## Breathlessness=No -9.812267
## exertion_triggered_asthma=No -10.299950
## infection_triggered_asthma=No -10.517718
## dyspenea=No -10.647707
## spt_any=Yes -13.203746
##
## $`5`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 17.3764906 91.891892 37.858755 5.328380e-69
## exertion_triggered_asthma=Yes 16.8053245 90.990991 38.761690 3.124815e-64
## weather_triggered_asthma=Yes 22.2222222 61.261261 19.735569 9.362554e-46
## Breathlessness=Yes 13.3379888 86.036036 46.178652 1.497959e-37
## allergen_triggered_asthma=Yes 17.9396092 45.495495 18.155434 1.273253e-22
## emotion_triggered_asthma=Yes 27.8787879 20.720721 5.320864 3.534170e-17
## irritant_triggered_asthma=Yes 20.7017544 26.576577 9.190584 2.872053e-15
## Cough=Yes 12.7921279 46.846847 26.217349 6.988167e-12
## gina_steps=step 1 or 2 16.1369193 29.729730 13.189294 1.560515e-11
## Chronic_productive_cough=Yes 13.8339921 31.531532 16.317317 5.129605e-09
## Recurrent_wheeze=Yes 13.4657837 27.477477 14.608191 2.282571e-07
## dyspenea=Yes 13.1182796 27.477477 14.995163 6.133857e-07
## urbanization_level=No 9.4653179 59.009009 44.630764 8.640735e-06
## Drug_induced_dyspnea=Yes 17.0940171 9.009009 3.772976 2.293268e-04
## gina_control=uncontrolled 12.0218579 19.819820 11.802644 3.474768e-04
## familial_allergy=Yes 8.7816456 50.000000 40.761045 3.977296e-03
## gina_control=partially controlled 8.6268871 54.054054 44.856498 4.444624e-03
## XCOPD=Yes 10.9489051 13.513514 8.835859 1.609744e-02
## smoking_exposure_at_work=No 8.0601827 67.567568 60.012899 1.630697e-02
## Gender=Yes 8.0362196 63.963964 56.981619 2.861409e-02
## Ever_rhinitis=Yes 7.7375566 77.027027 71.267333 4.630421e-02
## Ever_rhinitis=No 5.7239057 22.972973 28.732667 4.630421e-02
## Gender=No 5.9970015 36.036036 43.018381 2.861409e-02
## smoking_exposure_at_work=Yes 5.8064516 32.432432 39.987101 1.630697e-02
## XCOPD=No 6.7916519 86.486486 91.164141 1.609744e-02
## familial_allergy=No 6.0424605 50.000000 59.238955 3.977296e-03
## Drug_induced_dyspnea=No 6.7694370 90.990991 96.227024 2.293268e-04
## gina_steps=onlys saba or non users 6.1224490 64.864865 75.846501 1.363831e-04
## gina_steps=step4 or 5 1.3513514 1.351351 7.158981 5.122130e-05
## urbanization_level=Yes 5.2999418 40.990991 55.369236 8.640735e-06
## dyspenea=No 6.1077390 72.522523 85.004837 6.133857e-07
## Recurrent_wheeze=No 6.0800604 72.522523 85.391809 2.282571e-07
## gina_control=controlled 4.3154762 26.126126 43.340858 3.995992e-08
## Chronic_productive_cough=No 5.8574181 68.468468 83.682683 5.129605e-09
## Cough=No 5.1573427 53.153153 73.782651 6.988167e-12
## irritant_triggered_asthma=No 5.7883523 73.423423 90.809416 2.872053e-15
## emotion_triggered_asthma=No 5.9945504 79.279279 94.679136 3.534170e-17
## allergen_triggered_asthma=No 4.7675335 54.504505 81.844566 1.273253e-22
## Breathlessness=No 1.8573996 13.963964 53.821348 1.497959e-37
## weather_triggered_asthma=No 3.4552029 38.738739 80.264431 9.362554e-46
## exertion_triggered_asthma=No 1.0531859 9.009009 61.238310 3.124815e-64
## infection_triggered_asthma=No 0.9340944 8.108108 62.141245 5.328380e-69
## v.test
## infection_triggered_asthma=Yes 17.556247
## exertion_triggered_asthma=Yes 16.921479
## weather_triggered_asthma=Yes 14.198477
## Breathlessness=Yes 12.807010
## allergen_triggered_asthma=Yes 9.787565
## emotion_triggered_asthma=Yes 8.427404
## irritant_triggered_asthma=Yes 7.896343
## Cough=Yes 6.857897
## gina_steps=step 1 or 2 6.742158
## Chronic_productive_cough=Yes 5.842912
## Recurrent_wheeze=Yes 5.174717
## dyspenea=Yes 4.986954
## urbanization_level=No 4.448661
## Drug_induced_dyspnea=Yes 3.684306
## gina_control=uncontrolled 3.577063
## familial_allergy=Yes 2.879957
## gina_control=partially controlled 2.844750
## XCOPD=Yes 2.406699
## smoking_exposure_at_work=No 2.401972
## Gender=Yes 2.188763
## Ever_rhinitis=Yes 1.992610
## Ever_rhinitis=No -1.992610
## Gender=No -2.188763
## smoking_exposure_at_work=Yes -2.401972
## XCOPD=No -2.406699
## familial_allergy=No -2.879957
## Drug_induced_dyspnea=No -3.684306
## gina_steps=onlys saba or non users -3.814637
## gina_steps=step4 or 5 -4.049983
## urbanization_level=Yes -4.448661
## dyspenea=No -4.986954
## Recurrent_wheeze=No -5.174717
## gina_control=controlled -5.491029
## Chronic_productive_cough=No -5.842912
## Cough=No -6.857897
## irritant_triggered_asthma=No -7.896343
## emotion_triggered_asthma=No -8.427404
## allergen_triggered_asthma=No -9.787565
## Breathlessness=No -12.807010
## weather_triggered_asthma=No -14.198477
## exertion_triggered_asthma=No -16.921479
## infection_triggered_asthma=No -17.556247
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.389432004 0.000000e+00
## onset_age_asthma 0.330310208 3.020574e-266
## pack_years 0.262299519 2.163303e-201
## Basophiles 0.259281582 1.178785e-198
## kco 0.148440809 2.682519e-105
## tlco 0.138765170 9.506449e-98
## FEV1_FVC_ratio_post 0.121339027 2.258908e-84
## BMI 0.077053187 1.280722e-51
## Monocytes 0.062256399 4.561338e-41
## Reversibility 0.053532733 6.096708e-35
## pd20 0.053224407 1.000643e-34
## Neutrophiles 0.051812556 9.648026e-34
## Eosinophiles 0.050732517 5.444755e-33
## FeNO 0.025500709 8.444097e-16
## Lymphocytes 0.006901247 6.676611e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 11.170409 24.0902256 12.7716866 20.7081251
## pack_years 7.803028 17.4099041 11.2855015 18.6002037
## Reversibility 6.216431 8.3892739 5.9481072 8.9414856
## Age 6.026233 56.0000000 50.4795227 14.7844157
## Neutrophiles 5.563155 4.1974060 3.7574492 1.6554879
## pd20 4.078458 2939.5910286 2320.9569182 2377.3120544
## Eosinophiles 2.656120 0.2236090 0.2004192 0.2057988
## BMI 2.523409 27.3056742 26.6155247 5.0967585
## Monocytes 2.411941 0.4411278 0.4195937 0.1650320
## kco -6.209149 91.9120163 97.3779717 18.4415310
## tlco -6.667295 91.9192096 99.8125910 18.6342264
## FEV1_FVC_ratio_post -12.396491 0.7194919 0.7832420 0.1181598
## Overall sd p.value
## onset_age_asthma 1.728090e+01 5.691798e-29
## pack_years 1.338584e+01 6.043929e-15
## Reversibility 6.697326e+00 5.085884e-10
## Age 1.562341e+01 1.678248e-09
## Neutrophiles 1.348758e+00 2.649410e-08
## pd20 2.586920e+03 4.533547e-05
## Eosinophiles 1.488999e-01 7.904546e-03
## BMI 4.664452e+00 1.162230e-02
## Monocytes 1.522671e-01 1.586785e-02
## kco 1.501340e+01 5.327217e-10
## tlco 2.019103e+01 2.605603e-11
## FEV1_FVC_ratio_post 8.770554e-02 2.730198e-35
##
## $`1`
## v.test Mean in category Overall mean sd in category
## Age 25.771744 6.195914e+01 5.047952e+01 1.018727e+01
## pack_years 17.835044 1.809206e+01 1.128550e+01 1.495067e+01
## Monocytes 10.834500 4.666288e-01 4.195937e-01 1.741374e-01
## pd20 10.089739 3.065124e+03 2.320957e+03 2.877189e+03
## BMI 5.461360 2.734181e+01 2.661552e+01 4.462200e+00
## Lymphocytes 3.185330 2.021385e+00 1.962441e+00 7.552902e-01
## Neutrophiles 2.567958 3.856198e+00 3.757449e+00 1.356065e+00
## Basophiles -3.624605 2.321226e-02 2.780071e-02 4.023497e-02
## Reversibility -4.724290 5.046026e+00 5.948107e+00 6.016063e+00
## FEV1_FVC_ratio_post -4.740657 7.713878e-01 7.832420e-01 7.846644e-02
## onset_age_asthma -12.290588 6.716232e+00 1.277169e+01 1.414483e+01
## tlco -14.143472 9.167076e+01 9.981259e+01 1.347234e+01
## kco -16.374859 9.036884e+01 9.737797e+01 1.309994e+01
## Overall sd p.value
## Age 1.562341e+01 1.839438e-146
## pack_years 1.338584e+01 3.777527e-71
## Monocytes 1.522671e-01 2.362518e-27
## pd20 2.586920e+03 6.133229e-24
## BMI 4.664452e+00 4.725005e-08
## Lymphocytes 6.490450e-01 1.445890e-03
## Neutrophiles 1.348758e+00 1.022996e-02
## Basophiles 4.440150e-02 2.894031e-04
## Reversibility 6.697326e+00 2.309210e-06
## FEV1_FVC_ratio_post 8.770554e-02 2.130258e-06
## onset_age_asthma 1.728090e+01 1.017625e-34
## tlco 2.019103e+01 2.049186e-45
## kco 1.501340e+01 2.891790e-60
##
## $`2`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 16.781971 8.180343e-01 7.832420e-01 6.487305e-02
## tlco 14.282675 1.066294e+02 9.981259e+01 2.240961e+01
## kco 10.636994 1.011529e+02 9.737797e+01 1.264573e+01
## Lymphocytes -2.004244 1.931692e+00 1.962441e+00 5.417065e-01
## Basophiles -2.966444 2.468722e-02 2.780071e-02 4.122640e-02
## Eosinophiles -6.151834 1.787665e-01 2.004192e-01 1.249968e-01
## FeNO -6.835871 1.996890e+01 2.306080e+01 1.439700e+01
## Reversibility -7.101378 4.823872e+00 5.948107e+00 5.519655e+00
## pd20 -8.334886 1.811279e+03 2.320957e+03 2.375372e+03
## Neutrophiles -10.353254 3.427366e+00 3.757449e+00 1.148345e+00
## Monocytes -10.361471 3.822996e-01 4.195937e-01 1.282890e-01
## BMI -14.010075 2.507079e+01 2.661552e+01 4.001784e+00
## onset_age_asthma -15.263903 6.536564e+00 1.277169e+01 1.160473e+01
## pack_years -21.476887 4.489867e+00 1.128550e+01 4.863175e+00
## Age -28.951053 3.978767e+01 5.047952e+01 1.227539e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 3.306737e-63
## tlco 2.019103e+01 2.806191e-46
## kco 1.501340e+01 2.004941e-26
## Lymphocytes 6.490450e-01 4.504398e-02
## Basophiles 4.440150e-02 3.012655e-03
## Eosinophiles 1.488999e-01 7.659215e-10
## FeNO 1.913459e+01 8.150821e-12
## Reversibility 6.697326e+00 1.235189e-12
## pd20 2.586920e+03 7.757298e-17
## Neutrophiles 1.348758e+00 4.044978e-25
## Monocytes 1.522671e-01 3.712093e-25
## BMI 4.664452e+00 1.352617e-44
## onset_age_asthma 1.728090e+01 1.330459e-52
## pack_years 1.338584e+01 2.561039e-102
## Age 1.562341e+01 2.721882e-184
##
## $`3`
## v.test Mean in category Overall mean sd in category
## kco 9.190353 1.032560e+02 9.737797e+01 1.378810e+01
## onset_age_asthma 8.271574 1.886111e+01 1.277169e+01 1.370648e+01
## tlco 5.927571 1.049113e+02 9.981259e+01 1.953051e+01
## BMI 3.739910 2.735869e+01 2.661552e+01 4.834003e+00
## FeNO 2.463332 2.506880e+01 2.306080e+01 2.087457e+01
## Reversibility 2.383093 6.628037e+00 5.948107e+00 6.474964e+00
## Eosinophiles -2.110775 1.870299e-01 2.004192e-01 1.278117e-01
## Lymphocytes -3.097505 1.876795e+00 1.962441e+00 5.573012e-01
## Age -4.001473 4.781624e+01 5.047952e+01 1.346253e+01
## pd20 -4.093175 1.869865e+03 2.320957e+03 2.580339e+03
## Monocytes -5.062860 3.867521e-01 4.195937e-01 1.241042e-01
## pack_years -6.494806 7.581821e+00 1.128550e+01 7.460364e+00
## Basophiles -11.940978 5.213675e-03 2.780071e-02 1.964855e-02
## Overall sd p.value
## kco 15.0134018 3.915532e-20
## onset_age_asthma 17.2809024 1.322015e-16
## tlco 20.1910322 3.074477e-09
## BMI 4.6644519 1.840861e-04
## FeNO 19.1345916 1.376524e-02
## Reversibility 6.6973257 1.716784e-02
## Eosinophiles 0.1488999 3.479168e-02
## Lymphocytes 0.6490450 1.951572e-03
## Age 15.6234094 6.294932e-05
## pd20 2586.9202764 4.255069e-05
## Monocytes 0.1522671 4.130132e-07
## pack_years 13.3858429 8.314046e-11
## Basophiles 0.0444015 7.236726e-33
##
## $`4`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 23.626223 47.9689922 12.771687 13.7502293
## pack_years 14.404743 27.9081395 11.285501 19.3402639
## Age 12.547883 67.3798450 50.479523 8.0224431
## BMI 8.648868 30.0933565 26.615525 4.7295656
## Neutrophiles 7.102911 4.5833333 3.757449 1.5064118
## Reversibility 6.059312 9.4465390 5.948107 9.0230632
## pd20 3.079026 3007.6221709 2320.956918 2046.6611437
## FeNO 2.160579 26.6248062 23.060803 26.6865266
## FEV1_FVC_ratio_post -5.100267 0.7446792 0.783242 0.1208695
## kco -6.185932 89.3716512 97.377972 17.3658582
## tlco -8.753348 84.5762234 99.812591 16.4671810
## Overall sd p.value
## onset_age_asthma 1.728090e+01 2.072642e-123
## pack_years 1.338584e+01 4.831094e-47
## Age 1.562341e+01 4.082784e-36
## BMI 4.664452e+00 5.201286e-18
## Neutrophiles 1.348758e+00 1.221561e-12
## Reversibility 6.697326e+00 1.367053e-09
## pd20 2.586920e+03 2.076787e-03
## FeNO 1.913459e+01 3.072786e-02
## FEV1_FVC_ratio_post 8.770554e-02 3.391746e-07
## kco 1.501340e+01 6.173651e-10
## tlco 2.019103e+01 2.071139e-18
##
## $`5`
## v.test Mean in category Overall mean sd in category
## Basophiles 26.787306 0.1047297 2.780071e-02 2.782942e-02
## Eosinophiles 11.495205 0.3111261 2.004192e-01 2.087675e-01
## onset_age_asthma 8.103288 21.8288288 1.277169e+01 1.706763e+01
## kco 7.544127 104.7037138 9.737797e+01 1.410819e+01
## Reversibility 6.778803 8.8845254 5.948107e+00 7.881670e+00
## FeNO 6.412593 30.9970721 2.306080e+01 2.590986e+01
## tlco 3.845337 104.8343558 9.981259e+01 1.545559e+01
## Neutrophiles 3.485729 4.0615315 3.757449e+00 1.414938e+00
## Monocytes 3.316101 0.4522523 4.195937e-01 1.457981e-01
## BMI 1.991687 27.2164011 2.661552e+01 5.120462e+00
## pd20 -3.207780 1784.2327179 2.320957e+03 1.887515e+03
## FEV1_FVC_ratio_post -4.005935 0.7605175 7.832420e-01 9.643715e-02
## Overall sd p.value
## Basophiles 4.440150e-02 4.542341e-158
## Eosinophiles 1.488999e-01 1.394491e-30
## onset_age_asthma 1.728090e+01 5.349341e-16
## kco 1.501340e+01 4.553255e-14
## Reversibility 6.697326e+00 1.211759e-11
## FeNO 1.913459e+01 1.430649e-10
## tlco 2.019103e+01 1.203871e-04
## Neutrophiles 1.348758e+00 4.907978e-04
## Monocytes 1.522671e-01 9.128289e-04
## BMI 4.664452e+00 4.640541e-02
## pd20 2.586920e+03 1.337636e-03
## FEV1_FVC_ratio_post 8.770554e-02 6.177273e-051.1.3 Radar Plots
1.1.4 parallel box plots
1.1.5 parallel coordinate plot
1.2 Imporved Deep Empedding Clustering on the encoded data 4 clusters
1.2.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=536) | 1 (N=893) | 2 (N=797) | 3 (N=875) | Total (N=3101) | p value | |
|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||
| Â Â Â Mean (SD) | 64.578 (8.661) | 38.663 (11.228) | 41.359 (11.636) | 62.210 (9.485) | 50.480 (15.626) | |
| Â Â Â Range | 38.000 - 86.000 | 17.000 - 72.000 | 17.000 - 75.000 | 31.000 - 97.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | |||||
| Â Â Â No | 212 (39.6%) | 362 (40.5%) | 264 (33.1%) | 496 (56.7%) | 1334 (43.0%) | |
| Â Â Â Yes | 324 (60.4%) | 531 (59.5%) | 533 (66.9%) | 379 (43.3%) | 1767 (57.0%) | |
| BMI | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.303 (4.868) | 25.017 (4.223) | 26.520 (4.803) | 27.300 (4.319) | 26.616 (4.665) | |
| Â Â Â Range | 17.668 - 50.058 | 16.975 - 46.094 | 16.534 - 42.595 | 17.296 - 48.870 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||
| Â Â Â Mean (SD) | 37.616 (18.053) | 3.314 (7.644) | 14.714 (10.717) | 5.437 (12.984) | 12.772 (17.284) | |
| Â Â Â Range | -1.000 - 72.000 | -1.000 - 45.000 | -1.000 - 50.000 | -1.000 - 65.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||
| Â Â Â No | 272 (50.7%) | 785 (87.9%) | 550 (69.0%) | 681 (77.8%) | 2288 (73.8%) | |
| Â Â Â Yes | 264 (49.3%) | 108 (12.1%) | 247 (31.0%) | 194 (22.2%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | |||||
| Â Â Â No | 121 (22.6%) | 705 (78.9%) | 166 (20.8%) | 677 (77.4%) | 1669 (53.8%) | |
| Â Â Â Yes | 415 (77.4%) | 188 (21.1%) | 631 (79.2%) | 198 (22.6%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | |||||
| Â Â Â No | 360 (67.2%) | 852 (95.4%) | 626 (78.5%) | 810 (92.6%) | 2648 (85.4%) | |
| Â Â Â Yes | 176 (32.8%) | 41 (4.6%) | 171 (21.5%) | 65 (7.4%) | 453 (14.6%) | |
| dyspenea | < 0.001 | |||||
| Â Â Â No | 330 (61.6%) | 856 (95.9%) | 661 (82.9%) | 789 (90.2%) | 2636 (85.0%) | |
| Â Â Â Yes | 206 (38.4%) | 37 (4.1%) | 136 (17.1%) | 86 (9.8%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | |||||
| Â Â Â No | 340 (63.4%) | 843 (94.4%) | 656 (82.3%) | 756 (86.4%) | 2595 (83.7%) | |
| Â Â Â Yes | 196 (36.6%) | 50 (5.6%) | 141 (17.7%) | 119 (13.6%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.720 (0.111) | 0.826 (0.060) | 0.789 (0.079) | 0.773 (0.077) | 0.783 (0.088) | |
| Â Â Â Range | 0.267 - 1.590 | 0.568 - 1.180 | 0.259 - 1.009 | 0.230 - 1.028 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||
| Â Â Â Mean (SD) | 9.177 (9.366) | 4.020 (4.010) | 7.421 (7.070) | 4.596 (5.433) | 5.948 (6.698) | |
| Â Â Â Range | -20.000 - 67.273 | -12.603 - 56.067 | -26.774 - 77.242 | -6.696 - 42.557 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||
| Â Â Â Mean (SD) | 2972.379 (2101.582) | 1812.067 (2460.775) | 1509.344 (2244.558) | 3180.536 (2899.447) | 2320.957 (2587.337) | |
| Â Â Â Range | -1417.620 - 13923.750 | -23548.530 - 25908.750 | -6521.250 - 38775.000 | -26261.250 - 38775.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||
| Â Â Â Mean (SD) | 90.227 (21.199) | 107.578 (24.223) | 106.901 (13.285) | 91.303 (13.248) | 99.813 (20.194) | |
| Â Â Â Range | 44.477 - 389.709 | 67.134 - 680.093 | 67.252 - 161.534 | 44.453 - 136.107 | 44.453 - 680.093 | |
| kco | < 0.001 | |||||
| Â Â Â Mean (SD) | 91.428 (16.373) | 101.630 (12.766) | 104.921 (12.976) | 89.813 (12.906) | 97.378 (15.016) | |
| Â Â Â Range | 40.972 - 139.418 | 28.161 - 139.983 | 60.955 - 149.720 | 47.025 - 141.410 | 28.161 - 149.720 | |
| FeNO | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.600 (27.103) | 18.476 (12.338) | 24.856 (19.853) | 22.711 (17.079) | 23.061 (19.138) | |
| Â Â Â Range | 3.600 - 226.000 | 0.000 - 138.000 | 3.300 - 144.000 | 3.500 - 176.000 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.236 (0.190) | 0.172 (0.122) | 0.215 (0.156) | 0.194 (0.131) | 0.200 (0.149) | |
| Â Â Â Range | 0.010 - 2.300 | 0.000 - 0.900 | 0.000 - 1.200 | 0.000 - 1.000 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 4.195 (1.500) | 3.444 (1.182) | 3.744 (1.327) | 3.821 (1.351) | 3.757 (1.349) | |
| Â Â Â Range | 1.400 - 12.500 | 0.700 - 9.200 | 1.000 - 10.600 | 1.300 - 11.000 | 0.700 - 12.500 | |
| Lymphocyties | 0.121 | |||||
| Â Â Â Mean (SD) | 1.943 (0.779) | 1.936 (0.530) | 1.957 (0.561) | 2.005 (0.739) | 1.962 (0.649) | |
| Â Â Â Range | 0.400 - 11.200 | 0.300 - 4.000 | 0.600 - 5.000 | 0.300 - 9.400 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.446 (0.153) | 0.382 (0.148) | 0.400 (0.130) | 0.460 (0.162) | 0.420 (0.152) | |
| Â Â Â Range | 0.200 - 1.100 | 0.190 - 2.400 | 0.100 - 1.100 | 0.200 - 1.500 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.035 (0.051) | 0.023 (0.041) | 0.031 (0.045) | 0.026 (0.042) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.250 | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||
| Â Â Â No | 363 (67.7%) | 163 (18.3%) | 164 (20.6%) | 254 (29.0%) | 944 (30.4%) | |
| Â Â Â Yes | 173 (32.3%) | 730 (81.7%) | 633 (79.4%) | 621 (71.0%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | |||||
| Â Â Â No | 387 (72.2%) | 454 (50.8%) | 274 (34.4%) | 722 (82.5%) | 1837 (59.2%) | |
| Â Â Â Yes | 149 (27.8%) | 439 (49.2%) | 523 (65.6%) | 153 (17.5%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | |||||
| Â Â Â No | 494 (92.2%) | 881 (98.7%) | 748 (93.9%) | 861 (98.4%) | 2984 (96.2%) | |
| Â Â Â Yes | 42 (7.8%) | 12 (1.3%) | 49 (6.1%) | 14 (1.6%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | |||||
| Â Â Â No | 270 (50.4%) | 552 (61.8%) | 493 (61.9%) | 418 (47.8%) | 1733 (55.9%) | |
| Â Â Â Yes | 266 (49.6%) | 341 (38.2%) | 304 (38.1%) | 457 (52.2%) | 1368 (44.1%) | |
| Ever_rhinitis | < 0.001 | |||||
| Â Â Â No | 102 (19.0%) | 308 (34.5%) | 266 (33.4%) | 215 (24.6%) | 891 (28.7%) | |
| Â Â Â Yes | 434 (81.0%) | 585 (65.5%) | 531 (66.6%) | 660 (75.4%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | |||||
| Â Â Â onlys saba or non users | 300 (56.0%) | 808 (90.5%) | 482 (60.5%) | 762 (87.1%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 117 (21.8%) | 50 (5.6%) | 186 (23.3%) | 56 (6.4%) | 409 (13.2%) | |
| Â Â Â step3 | 25 (4.7%) | 20 (2.2%) | 57 (7.2%) | 16 (1.8%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 94 (17.5%) | 15 (1.7%) | 72 (9.0%) | 41 (4.7%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | |||||
| Â Â Â No | 487 (90.9%) | 860 (96.3%) | 777 (97.5%) | 814 (93.0%) | 2938 (94.7%) | |
| Â Â Â Yes | 49 (9.1%) | 33 (3.7%) | 20 (2.5%) | 61 (7.0%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | |||||
| Â Â Â No | 402 (75.0%) | 810 (90.7%) | 690 (86.6%) | 738 (84.3%) | 2640 (85.1%) | |
| Â Â Â Yes | 134 (25.0%) | 83 (9.3%) | 107 (13.4%) | 137 (15.7%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | |||||
| Â Â Â No | 380 (70.9%) | 854 (95.6%) | 670 (84.1%) | 804 (91.9%) | 2708 (87.3%) | |
| Â Â Â Yes | 156 (29.1%) | 39 (4.4%) | 127 (15.9%) | 71 (8.1%) | 393 (12.7%) | |
| gina_control | < 0.001 | |||||
| Â Â Â controlled | 134 (25.0%) | 514 (57.6%) | 288 (36.1%) | 408 (46.6%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 294 (54.9%) | 325 (36.4%) | 400 (50.2%) | 372 (42.5%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 108 (20.1%) | 54 (6.0%) | 109 (13.7%) | 95 (10.9%) | 366 (11.8%) | |
| education | < 0.001 | |||||
| Â Â Â primary | 202 (37.7%) | 508 (56.9%) | 454 (57.0%) | 327 (37.4%) | 1491 (48.1%) | |
| Â Â Â secondary | 212 (39.6%) | 344 (38.5%) | 299 (37.5%) | 367 (41.9%) | 1222 (39.4%) | |
| Â Â Â tertiary | 122 (22.8%) | 41 (4.6%) | 44 (5.5%) | 181 (20.7%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | |||||
| Â Â Â No | 348 (64.9%) | 254 (28.4%) | 437 (54.8%) | 345 (39.4%) | 1384 (44.6%) | |
| Â Â Â Yes | 188 (35.1%) | 639 (71.6%) | 360 (45.2%) | 530 (60.6%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | |||||
| Â Â Â never smoker | 222 (41.4%) | 611 (68.4%) | 516 (64.7%) | 333 (38.1%) | 1682 (54.2%) | |
| Â Â Â former smokers | 268 (50.0%) | 224 (25.1%) | 223 (28.0%) | 433 (49.5%) | 1148 (37.0%) | |
| Â Â Â current smoker | 46 (8.6%) | 58 (6.5%) | 58 (7.3%) | 109 (12.5%) | 271 (8.7%) | |
| pack_years | < 0.001 | |||||
| Â Â Â Mean (SD) | 20.266 (16.596) | 4.359 (4.754) | 6.092 (6.461) | 17.584 (15.597) | 11.286 (13.388) | |
| Â Â Â Range | 0.000 - 88.000 | 0.000 - 48.000 | 0.000 - 44.000 | 0.000 - 112.500 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | |||||
| Â Â Â No | 129 (24.1%) | 467 (52.3%) | 352 (44.2%) | 236 (27.0%) | 1184 (38.2%) | |
| Â Â Â Yes | 407 (75.9%) | 426 (47.7%) | 445 (55.8%) | 639 (73.0%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | |||||
| Â Â Â No | 238 (44.4%) | 713 (79.8%) | 569 (71.4%) | 341 (39.0%) | 1861 (60.0%) | |
| Â Â Â Yes | 298 (55.6%) | 180 (20.2%) | 228 (28.6%) | 534 (61.0%) | 1240 (40.0%) | |
| household_damage | < 0.001 | |||||
| Â Â Â No | 492 (91.8%) | 751 (84.1%) | 676 (84.8%) | 813 (92.9%) | 2732 (88.1%) | |
| Â Â Â Yes | 44 (8.2%) | 142 (15.9%) | 121 (15.2%) | 62 (7.1%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 100 (18.7%) | 868 (97.2%) | 72 (9.0%) | 859 (98.2%) | 1899 (61.2%) | |
| Â Â Â Yes | 436 (81.3%) | 25 (2.8%) | 725 (91.0%) | 16 (1.8%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 86 (16.0%) | 876 (98.1%) | 104 (13.0%) | 861 (98.4%) | 1927 (62.1%) | |
| Â Â Â Yes | 450 (84.0%) | 17 (1.9%) | 693 (87.0%) | 14 (1.6%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 372 (69.4%) | 874 (97.9%) | 435 (54.6%) | 857 (97.9%) | 2538 (81.8%) | |
| Â Â Â Yes | 164 (30.6%) | 19 (2.1%) | 362 (45.4%) | 18 (2.1%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 432 (80.6%) | 890 (99.7%) | 623 (78.2%) | 871 (99.5%) | 2816 (90.8%) | |
| Â Â Â Yes | 104 (19.4%) | 3 (0.3%) | 174 (21.8%) | 4 (0.5%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 297 (55.4%) | 891 (99.8%) | 428 (53.7%) | 873 (99.8%) | 2489 (80.3%) | |
| Â Â Â Yes | 239 (44.6%) | 2 (0.2%) | 369 (46.3%) | 2 (0.2%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 465 (86.8%) | 893 (100.0%) | 703 (88.2%) | 875 (100.0%) | 2936 (94.7%) | |
| Â Â Â Yes | 71 (13.2%) | 0 (0.0%) | 94 (11.8%) | 0 (0.0%) | 165 (5.3%) | |
| XCOPD | < 0.001 | |||||
| Â Â Â No | 386 (72.0%) | 878 (98.3%) | 746 (93.6%) | 817 (93.4%) | 2827 (91.2%) | |
| Â Â Â Yes | 150 (28.0%) | 15 (1.7%) | 51 (6.4%) | 58 (6.6%) | 274 (8.8%) |
1.2.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## exertion_triggered_asthma 0.000000e+00 3
## infection_triggered_asthma 0.000000e+00 3
## weather_triggered_asthma 4.747645e-214 3
## Breathlessness 1.666004e-212 3
## allergen_triggered_asthma 9.449907e-165 3
## familial_allergy 3.523396e-100 3
## spt_any 1.233988e-97 3
## smoking_exposure_at_work 1.651939e-87 3
## gina_steps 1.386755e-85 9
## irritant_triggered_asthma 8.541059e-83 3
## dyspenea 3.394633e-72 3
## XCOPD 2.587899e-67 3
## Recurrent_wheeze 1.489965e-60 3
## Cough 3.426309e-55 3
## Chronic_productive_cough 3.648525e-52 3
## emotion_triggered_asthma 4.013829e-50 3
## smoking_status 2.267086e-49 6
## urbanization_level 5.685123e-49 3
## education 6.407050e-47 6
## severe_asthma 2.251469e-45 3
## smoking_exposure_at_home 1.258339e-38 3
## gina_control 1.088980e-37 6
## Gender 2.918871e-22 3
## Emergency_last_year 1.751468e-14 3
## Drug_induced_dyspnea 1.598144e-13 3
## Ever_rhinitis 7.252088e-12 3
## nasal_plyposis 1.001038e-11 3
## household_damage 1.989926e-10 3
## Hosptalization_last_year 3.023782e-08 3
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 38.330494 83.955224 37.858755 6.833060e-130
## exertion_triggered_asthma=Yes 36.272879 81.343284 38.761690 6.615743e-110
## spt_any=No 38.453390 67.723881 30.441793 3.278680e-87
## Breathlessness=Yes 28.980447 77.425373 46.178652 4.992018e-59
## dyspenea=Yes 44.301075 38.432836 14.995163 1.691968e-51
## XCOPD=Yes 54.744526 27.985075 8.835859 1.667981e-50
## weather_triggered_asthma=Yes 39.052288 44.589552 19.735569 6.241464e-49
## Chronic_productive_cough=Yes 38.735178 36.567164 16.317317 1.537132e-37
## Cough=Yes 32.472325 49.253731 26.217349 6.399844e-37
## Recurrent_wheeze=Yes 38.852097 32.835821 14.608191 3.099841e-33
## severe_asthma=Yes 39.694656 29.104478 12.673331 3.191270e-30
## urbanization_level=No 25.144509 64.925373 44.630764 3.011280e-25
## gina_steps=step4 or 5 42.342342 17.537313 7.158981 6.115507e-20
## irritant_triggered_asthma=Yes 36.491228 19.402985 9.190584 2.306721e-16
## smoking_exposure_at_work=Yes 24.032258 55.597015 39.987101 1.020282e-15
## emotion_triggered_asthma=Yes 43.030303 13.246269 5.320864 1.524920e-15
## allergen_triggered_asthma=Yes 29.129663 30.597015 18.155434 7.086093e-15
## smoking_exposure_at_home=Yes 21.231090 75.932836 61.818768 3.399295e-14
## education=tertiary 31.443299 22.761194 12.512093 1.920224e-13
## Emergency_last_year=Yes 29.067245 25.000000 14.866172 7.743616e-12
## familial_allergy=No 21.066957 72.201493 59.238955 8.307149e-12
## smoking_status=former smokers 23.344948 50.000000 37.020316 1.527156e-11
## gina_control=uncontrolled 29.508197 20.149254 11.802644 6.285682e-10
## gina_steps=step 1 or 2 28.606357 21.828358 13.189294 8.589777e-10
## Ever_rhinitis=Yes 19.638009 80.970149 71.267333 1.840581e-08
## gina_control=partially controlled 21.135873 54.850746 44.856498 3.457144e-07
## Drug_induced_dyspnea=Yes 35.897436 7.835821 3.772976 8.628855e-07
## Hosptalization_last_year=Yes 30.061350 9.141791 5.256369 3.697104e-05
## household_damage=No 18.008785 91.791045 88.100613 2.702842e-03
## nasal_plyposis=Yes 19.444444 49.626866 44.114802 4.857163e-03
## nasal_plyposis=No 15.579919 50.373134 55.885198 4.857163e-03
## household_damage=Yes 11.924119 8.208955 11.899387 2.702842e-03
## Hosptalization_last_year=No 16.575902 90.858209 94.743631 3.697104e-05
## Drug_induced_dyspnea=No 16.554960 92.164179 96.227024 8.628855e-07
## education=primary 13.547954 37.686567 48.081264 1.056781e-07
## Ever_rhinitis=No 11.447811 19.029851 28.732667 1.840581e-08
## smoking_status=never smoker 13.198573 41.417910 54.240568 6.270701e-11
## familial_allergy=Yes 11.787975 27.798507 40.761045 8.307149e-12
## Emergency_last_year=No 15.227273 75.000000 85.133828 7.743616e-12
## smoking_exposure_at_home=No 10.895270 24.067164 38.181232 3.399295e-14
## allergen_triggered_asthma=No 14.657210 69.402985 81.844566 7.086093e-15
## emotion_triggered_asthma=No 15.837875 86.753731 94.679136 1.524920e-15
## smoking_exposure_at_work=No 12.788823 44.402985 60.012899 1.020282e-15
## irritant_triggered_asthma=No 15.340909 80.597015 90.809416 2.306721e-16
## gina_control=controlled 9.970238 25.000000 43.340858 5.279539e-22
## urbanization_level=Yes 10.949330 35.074627 55.369236 3.011280e-25
## gina_steps=onlys saba or non users 12.755102 55.970149 75.846501 2.979318e-29
## severe_asthma=No 14.032496 70.895522 87.326669 3.191270e-30
## Recurrent_wheeze=No 13.595166 67.164179 85.391809 3.099841e-33
## Cough=No 11.888112 50.746269 73.782651 6.399844e-37
## Chronic_productive_cough=No 13.102119 63.432836 83.682683 1.537132e-37
## weather_triggered_asthma=No 11.932503 55.410448 80.264431 6.241464e-49
## XCOPD=No 13.654050 72.014925 91.164141 1.667981e-50
## dyspenea=No 12.518968 61.567164 85.004837 1.691968e-51
## Breathlessness=No 7.249850 22.574627 53.821348 4.992018e-59
## spt_any=Yes 8.020399 32.276119 69.558207 3.278680e-87
## exertion_triggered_asthma=No 5.265929 18.656716 61.238310 6.615743e-110
## infection_triggered_asthma=No 4.462896 16.044776 62.141245 6.833060e-130
## v.test
## infection_triggered_asthma=Yes 24.248647
## exertion_triggered_asthma=Yes 22.273917
## spt_any=No 19.795136
## Breathlessness=Yes 16.200621
## dyspenea=Yes 15.097107
## XCOPD=Yes 14.945435
## weather_triggered_asthma=Yes 14.702183
## Chronic_productive_cough=Yes 12.805006
## Cough=Yes 12.693806
## Recurrent_wheeze=Yes 12.011287
## severe_asthma=Yes 11.423498
## urbanization_level=No 10.381462
## gina_steps=step4 or 5 9.142270
## irritant_triggered_asthma=Yes 8.204958
## smoking_exposure_at_work=Yes 8.024394
## emotion_triggered_asthma=Yes 7.974910
## allergen_triggered_asthma=Yes 7.782935
## smoking_exposure_at_home=Yes 7.582129
## education=tertiary 7.354236
## Emergency_last_year=Yes 6.843213
## familial_allergy=No 6.833147
## smoking_status=former smokers 6.745296
## gina_control=uncontrolled 6.183095
## gina_steps=step 1 or 2 6.133627
## Ever_rhinitis=Yes 5.626354
## gina_control=partially controlled 5.096651
## Drug_induced_dyspnea=Yes 4.920579
## Hosptalization_last_year=Yes 4.125637
## household_damage=No 2.999657
## nasal_plyposis=Yes 2.816357
## nasal_plyposis=No -2.816357
## household_damage=Yes -2.999657
## Hosptalization_last_year=No -4.125637
## Drug_induced_dyspnea=No -4.920579
## education=primary -5.316679
## Ever_rhinitis=No -5.626354
## smoking_status=never smoker -6.537138
## familial_allergy=Yes -6.833147
## Emergency_last_year=No -6.843213
## smoking_exposure_at_home=No -7.582129
## allergen_triggered_asthma=No -7.782935
## emotion_triggered_asthma=No -7.974910
## smoking_exposure_at_work=No -8.024394
## irritant_triggered_asthma=No -8.204958
## gina_control=controlled -9.642672
## urbanization_level=Yes -10.381462
## gina_steps=onlys saba or non users -11.227761
## severe_asthma=No -11.423498
## Recurrent_wheeze=No -12.011287
## Cough=No -12.693806
## Chronic_productive_cough=No -12.805006
## weather_triggered_asthma=No -14.702183
## XCOPD=No -14.945435
## dyspenea=No -15.097107
## Breathlessness=No -16.200621
## spt_any=Yes -19.795136
## exertion_triggered_asthma=No -22.273917
## infection_triggered_asthma=No -24.248647
##
## $`1`
## Cla/Mod Mod/Cla Global
## infection_triggered_asthma=No 45.4592631 98.0963046 62.141245
## exertion_triggered_asthma=No 45.7082675 97.2004479 61.238310
## weather_triggered_asthma=No 35.7975090 99.7760358 80.264431
## Breathlessness=No 42.2408628 78.9473684 53.821348
## allergen_triggered_asthma=No 34.4365642 97.8723404 81.844566
## smoking_exposure_at_work=No 38.3127351 79.8432251 60.012899
## irritant_triggered_asthma=No 31.6051136 99.6640538 90.809416
## gina_steps=onlys saba or non users 34.3537415 90.4815230 75.846501
## Cough=No 34.3094406 87.9059351 73.782651
## dyspenea=No 32.4734446 95.8566629 85.004837
## urbanization_level=Yes 37.2160745 71.5565510 55.369236
## Chronic_productive_cough=No 32.4855491 94.4008959 83.682683
## Recurrent_wheeze=No 32.1752266 95.4087346 85.391809
## emotion_triggered_asthma=No 30.4155313 100.0000000 94.679136
## smoking_exposure_at_home=No 39.4425676 52.2956327 38.181232
## smoking_status=never smoker 36.3258026 68.4210526 54.240568
## XCOPD=No 31.0576583 98.3202688 91.164141
## gina_control=controlled 38.2440476 57.5587906 43.340858
## spt_any=Yes 33.8433009 81.7469205 69.558207
## severe_asthma=No 31.5361891 95.6326988 87.326669
## education=primary 34.0710932 56.8868981 48.081264
## familial_allergy=Yes 34.7310127 49.1601344 40.761045
## Emergency_last_year=No 30.6818182 90.7054871 85.133828
## Drug_induced_dyspnea=No 29.5241287 98.6562150 96.227024
## Ever_rhinitis=No 34.5679012 34.4904815 28.732667
## household_damage=Yes 38.4823848 15.9014558 11.899387
## nasal_plyposis=No 31.8522793 61.8141097 55.885198
## Hosptalization_last_year=No 29.2716133 96.3045913 94.743631
## Hosptalization_last_year=Yes 20.2453988 3.6954087 5.256369
## smoking_status=current smoker 21.4022140 6.4949608 8.739116
## gina_steps=step3 16.9491525 2.2396417 3.805224
## nasal_plyposis=Yes 24.9269006 38.1858903 44.114802
## household_damage=No 27.4890190 84.0985442 88.100613
## Ever_rhinitis=Yes 26.4705882 65.5095185 71.267333
## Drug_induced_dyspnea=Yes 10.2564103 1.3437850 3.772976
## Emergency_last_year=Yes 18.0043384 9.2945129 14.866172
## familial_allergy=No 24.7142079 50.8398656 59.238955
## gina_control=partially controlled 23.3644860 36.3941769 44.856498
## gina_control=uncontrolled 14.7540984 6.0470325 11.802644
## gina_steps=step4 or 5 6.7567568 1.6797312 7.158981
## gina_steps=step 1 or 2 12.2249389 5.5991041 13.189294
## smoking_status=former smokers 19.5121951 25.0839866 37.020316
## education=tertiary 10.5670103 4.5912654 12.512093
## severe_asthma=Yes 9.9236641 4.3673012 12.673331
## spt_any=No 17.2669492 18.2530795 30.441793
## XCOPD=Yes 5.4744526 1.6797312 8.835859
## smoking_exposure_at_home=Yes 22.2222222 47.7043673 61.818768
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## Recurrent_wheeze=Yes 9.0507726 4.5912654 14.608191
## Chronic_productive_cough=Yes 9.8814229 5.5991041 16.317317
## urbanization_level=No 18.3526012 28.4434490 44.630764
## dyspenea=Yes 7.9569892 4.1433371 14.995163
## Cough=Yes 13.2841328 12.0940649 26.217349
## irritant_triggered_asthma=Yes 1.0526316 0.3359462 9.190584
## smoking_exposure_at_work=Yes 14.5161290 20.1567749 39.987101
## allergen_triggered_asthma=Yes 3.3747780 2.1276596 18.155434
## Breathlessness=Yes 13.1284916 21.0526316 46.178652
## weather_triggered_asthma=Yes 0.3267974 0.2239642 19.735569
## exertion_triggered_asthma=Yes 2.0798669 2.7995521 38.761690
## infection_triggered_asthma=Yes 1.4480409 1.9036954 37.858755
## p.value v.test
## infection_triggered_asthma=No 6.344399e-195 29.783742
## exertion_triggered_asthma=No 8.168408e-189 29.308138
## weather_triggered_asthma=No 7.283907e-99 21.104159
## Breathlessness=No 5.672286e-75 18.320563
## allergen_triggered_asthma=No 2.260167e-64 16.940546
## smoking_exposure_at_work=No 2.209073e-49 14.772340
## irritant_triggered_asthma=No 1.215553e-39 13.175416
## gina_steps=onlys saba or non users 4.541549e-38 12.899308
## Cough=No 5.594681e-33 11.962363
## dyspenea=No 1.884695e-32 11.861106
## urbanization_level=Yes 1.406715e-31 11.691624
## Chronic_productive_cough=No 8.236859e-29 11.137534
## Recurrent_wheeze=No 5.011610e-28 10.975521
## emotion_triggered_asthma=No 7.268631e-26 10.516281
## smoking_exposure_at_home=No 2.032851e-24 10.197575
## smoking_status=never smoker 2.520053e-24 10.176683
## XCOPD=No 3.814896e-24 10.136243
## gina_control=controlled 4.096158e-24 10.129289
## spt_any=Yes 4.303578e-22 9.663626
## severe_asthma=No 6.876033e-22 9.615521
## education=primary 4.364631e-10 6.240396
## familial_allergy=Yes 1.717204e-09 6.022522
## Emergency_last_year=No 8.974205e-09 5.749058
## Drug_induced_dyspnea=No 9.556883e-07 4.900550
## Ever_rhinitis=No 8.253445e-06 4.458502
## household_damage=Yes 1.940689e-05 4.271608
## nasal_plyposis=No 2.230645e-05 4.240458
## Hosptalization_last_year=No 1.120634e-02 2.536198
## Hosptalization_last_year=Yes 1.120634e-02 -2.536198
## smoking_status=current smoker 4.060022e-03 -2.873460
## gina_steps=step3 2.604740e-03 -3.010901
## nasal_plyposis=Yes 2.230645e-05 -4.240458
## household_damage=No 1.940689e-05 -4.271608
## Ever_rhinitis=Yes 8.253445e-06 -4.458502
## Drug_induced_dyspnea=Yes 9.556883e-07 -4.900550
## Emergency_last_year=Yes 8.974205e-09 -5.749058
## familial_allergy=No 1.717204e-09 -6.022522
## gina_control=partially controlled 1.422191e-09 -6.052948
## gina_control=uncontrolled 2.642003e-11 -6.665258
## gina_steps=step4 or 5 3.206459e-17 -8.438788
## gina_steps=step 1 or 2 1.875231e-17 -8.501273
## smoking_status=former smokers 5.127870e-19 -8.909467
## education=tertiary 4.370844e-20 -9.178513
## severe_asthma=Yes 6.876033e-22 -9.615521
## spt_any=No 4.303578e-22 -9.663626
## XCOPD=Yes 3.814896e-24 -10.136243
## smoking_exposure_at_home=Yes 2.032851e-24 -10.197575
## emotion_triggered_asthma=Yes 7.268631e-26 -10.516281
## Recurrent_wheeze=Yes 5.011610e-28 -10.975521
## Chronic_productive_cough=Yes 8.236859e-29 -11.137534
## urbanization_level=No 1.406715e-31 -11.691624
## dyspenea=Yes 1.884695e-32 -11.861106
## Cough=Yes 5.594681e-33 -11.962363
## irritant_triggered_asthma=Yes 1.215553e-39 -13.175416
## smoking_exposure_at_work=Yes 2.209073e-49 -14.772340
## allergen_triggered_asthma=Yes 2.260167e-64 -16.940546
## Breathlessness=Yes 5.672286e-75 -18.320563
## weather_triggered_asthma=Yes 7.283907e-99 -21.104159
## exertion_triggered_asthma=Yes 8.168408e-189 -29.308138
## infection_triggered_asthma=Yes 6.344399e-195 -29.783742
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 60.316140 90.966123 38.761690 9.456290e-286
## infection_triggered_asthma=Yes 59.028961 86.951066 37.858755 1.273039e-248
## Breathlessness=Yes 44.064246 79.171895 46.178652 4.756910e-108
## allergen_triggered_asthma=Yes 64.298401 45.420326 18.155434 3.123570e-105
## weather_triggered_asthma=Yes 60.294118 46.298620 19.735569 8.188748e-95
## familial_allergy=Yes 41.376582 65.621079 40.761045 4.145711e-61
## irritant_triggered_asthma=Yes 61.052632 21.831870 9.190584 2.552080e-40
## gina_steps=step 1 or 2 45.476773 23.337516 13.189294 9.929965e-21
## emotion_triggered_asthma=Yes 56.969697 11.794228 5.320864 2.115946e-18
## smoking_exposure_at_work=No 30.574960 71.392723 60.012899 1.235898e-14
## spt_any=Yes 29.346314 79.422836 69.558207 6.460045e-13
## smoking_status=never smoker 30.677765 64.742785 54.240568 3.767187e-12
## urbanization_level=No 31.575145 54.830615 44.630764 2.072201e-11
## Gender=Yes 30.164120 66.875784 56.981619 4.178341e-11
## Recurrent_wheeze=Yes 37.748344 21.455458 14.608191 8.497693e-10
## education=primary 30.449363 56.963614 48.081264 5.855883e-09
## gina_steps=step3 48.305085 7.151819 3.805224 8.004991e-08
## Hosptalization_last_year=No 26.446562 97.490590 94.743631 1.750598e-05
## smoking_exposure_at_home=No 29.729730 44.165621 38.181232 6.061639e-05
## nasal_plyposis=No 28.447778 61.856964 55.885198 7.785660e-05
## Drug_induced_dyspnea=Yes 41.880342 6.148055 3.772976 1.053233e-04
## Cough=Yes 30.381304 30.991217 26.217349 4.410747e-04
## gina_control=partially controlled 28.756290 50.188206 44.856498 4.604064e-04
## Ever_rhinitis=No 29.854097 33.375157 28.732667 8.742109e-04
## household_damage=Yes 32.791328 15.181932 11.899387 1.167196e-03
## severe_asthma=Yes 32.315522 15.934755 12.673331 1.661313e-03
## XCOPD=No 26.388398 93.601004 91.164141 3.943248e-03
## gina_steps=step4 or 5 32.432432 9.033877 7.158981 1.979139e-02
## XCOPD=Yes 18.613139 6.398996 8.835859 3.943248e-03
## severe_asthma=No 24.741507 84.065245 87.326669 1.661313e-03
## household_damage=No 24.743777 84.818068 88.100613 1.167196e-03
## Ever_rhinitis=Yes 24.027149 66.624843 71.267333 8.742109e-04
## Cough=No 24.038462 69.008783 73.782651 4.410747e-04
## Drug_induced_dyspnea=No 25.067024 93.851945 96.227024 1.053233e-04
## nasal_plyposis=Yes 22.222222 38.143036 44.114802 7.785660e-05
## smoking_exposure_at_home=Yes 23.213354 55.834379 61.818768 6.061639e-05
## Hosptalization_last_year=Yes 12.269939 2.509410 5.256369 1.750598e-05
## gina_control=controlled 21.428571 36.135508 43.340858 1.715263e-06
## Recurrent_wheeze=No 23.640483 78.544542 85.391809 8.497693e-10
## smoking_status=former smokers 19.425087 27.979925 37.020316 5.276074e-10
## Gender=No 19.790105 33.124216 43.018381 4.178341e-11
## urbanization_level=Yes 20.966803 45.169385 55.369236 2.072201e-11
## spt_any=No 17.372881 20.577164 30.441793 6.460045e-13
## education=tertiary 11.340206 5.520703 12.512093 1.181291e-13
## smoking_exposure_at_work=Yes 18.387097 28.607277 39.987101 1.235898e-14
## emotion_triggered_asthma=No 23.944142 88.205772 94.679136 2.115946e-18
## gina_steps=onlys saba or non users 20.493197 60.476788 75.846501 5.698794e-30
## irritant_triggered_asthma=No 22.123580 78.168130 90.809416 2.552080e-40
## familial_allergy=No 14.915623 34.378921 59.238955 4.145711e-61
## weather_triggered_asthma=No 17.195661 53.701380 80.264431 8.188748e-95
## allergen_triggered_asthma=No 17.139480 54.579674 81.844566 3.123570e-105
## Breathlessness=No 9.946075 20.828105 53.821348 4.756910e-108
## infection_triggered_asthma=No 5.396990 13.048934 62.141245 1.273039e-248
## exertion_triggered_asthma=No 3.791469 9.033877 61.238310 9.456290e-286
## v.test
## exertion_triggered_asthma=Yes 36.124206
## infection_triggered_asthma=Yes 33.676586
## Breathlessness=Yes 22.081532
## allergen_triggered_asthma=Yes 21.786385
## weather_triggered_asthma=Yes 20.658489
## familial_allergy=Yes 16.492621
## irritant_triggered_asthma=Yes 13.292698
## gina_steps=step 1 or 2 9.336789
## emotion_triggered_asthma=Yes 8.750934
## smoking_exposure_at_work=No 7.712280
## spt_any=Yes 7.190403
## smoking_status=never smoker 6.945651
## urbanization_level=No 6.700843
## Gender=Yes 6.597612
## Recurrent_wheeze=Yes 6.135341
## education=primary 5.820822
## gina_steps=step3 5.367016
## Hosptalization_last_year=No 4.294535
## smoking_exposure_at_home=No 4.010398
## nasal_plyposis=No 3.950904
## Drug_induced_dyspnea=Yes 3.877990
## Cough=Yes 3.514204
## gina_control=partially controlled 3.502793
## Ever_rhinitis=No 3.328162
## household_damage=Yes 3.246778
## severe_asthma=Yes 3.144922
## XCOPD=No 2.882666
## gina_steps=step4 or 5 2.330279
## XCOPD=Yes -2.882666
## severe_asthma=No -3.144922
## household_damage=No -3.246778
## Ever_rhinitis=Yes -3.328162
## Cough=No -3.514204
## Drug_induced_dyspnea=No -3.877990
## nasal_plyposis=Yes -3.950904
## smoking_exposure_at_home=Yes -4.010398
## Hosptalization_last_year=Yes -4.294535
## gina_control=controlled -4.784368
## Recurrent_wheeze=No -6.135341
## smoking_status=former smokers -6.210665
## Gender=No -6.597612
## urbanization_level=Yes -6.700843
## spt_any=No -7.190403
## education=tertiary -7.418864
## smoking_exposure_at_work=Yes -7.712280
## emotion_triggered_asthma=No -8.750934
## gina_steps=onlys saba or non users -11.373010
## irritant_triggered_asthma=No -13.292698
## familial_allergy=No -16.492621
## weather_triggered_asthma=No -20.658489
## allergen_triggered_asthma=No -21.786385
## Breathlessness=No -22.081532
## infection_triggered_asthma=No -33.676586
## exertion_triggered_asthma=No -36.124206
##
## $`3`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 45.2343339 98.1714286 61.238310
## infection_triggered_asthma=No 44.6808511 98.4000000 62.141245
## weather_triggered_asthma=No 35.0743270 99.7714286 80.264431
## familial_allergy=No 39.3032118 82.5142857 59.238955
## Breathlessness=No 40.5632115 77.3714286 53.821348
## allergen_triggered_asthma=No 33.7667455 97.9428571 81.844566
## smoking_exposure_at_work=Yes 43.0645161 61.0285714 39.987101
## irritant_triggered_asthma=No 30.9303977 99.5428571 90.809416
## emotion_triggered_asthma=No 29.8024523 100.0000000 94.679136
## Gender=No 37.1814093 56.6857143 43.018381
## gina_steps=onlys saba or non users 32.3979592 87.0857143 75.846501
## smoking_status=former smokers 37.7177700 49.4857143 37.020316
## education=tertiary 46.6494845 20.6857143 12.512093
## smoking_exposure_at_home=Yes 33.3333333 73.0285714 61.818768
## Recurrent_wheeze=No 30.5891239 92.5714286 85.391809
## nasal_plyposis=Yes 33.4064327 52.2285714 44.114802
## household_damage=No 29.7584187 92.9142857 88.100613
## dyspenea=No 29.9317147 90.1714286 85.004837
## severe_asthma=No 29.6898080 91.8857143 87.326669
## smoking_status=current smoker 40.2214022 12.4571429 8.739116
## Drug_induced_dyspnea=No 28.8538874 98.4000000 96.227024
## urbanization_level=Yes 30.8677927 60.5714286 55.369236
## Cough=No 29.7639860 77.8285714 73.782651
## Ever_rhinitis=Yes 29.8642534 75.4285714 71.267333
## XCOPD=No 28.8998939 93.3714286 91.164141
## Hosptalization_last_year=Yes 37.4233129 6.9714286 5.256369
## Chronic_productive_cough=No 29.1329480 86.4000000 83.682683
## gina_control=controlled 30.3571429 46.6285714 43.340858
## Chronic_productive_cough=Yes 23.5177866 13.6000000 16.317317
## Hosptalization_last_year=No 27.7059224 93.0285714 94.743631
## XCOPD=Yes 21.1678832 6.6285714 8.835859
## Ever_rhinitis=No 24.1301908 24.5714286 28.732667
## Cough=Yes 23.8622386 22.1714286 26.217349
## gina_steps=step4 or 5 18.4684685 4.6857143 7.158981
## urbanization_level=No 24.9277457 39.4285714 44.630764
## gina_steps=step3 13.5593220 1.8285714 3.805224
## Drug_induced_dyspnea=Yes 11.9658120 1.6000000 3.772976
## severe_asthma=Yes 18.0661578 8.1142857 12.673331
## dyspenea=Yes 18.4946237 9.8285714 14.995163
## household_damage=Yes 16.8021680 7.0857143 11.899387
## nasal_plyposis=No 24.1200231 47.7714286 55.885198
## gina_steps=step 1 or 2 13.6919315 6.4000000 13.189294
## Recurrent_wheeze=Yes 14.3487859 7.4285714 14.608191
## education=primary 21.9315895 37.3714286 48.081264
## smoking_exposure_at_home=No 19.9324324 26.9714286 38.181232
## Gender=Yes 21.4487832 43.3142857 56.981619
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## smoking_status=never smoker 19.7978597 38.0571429 54.240568
## irritant_triggered_asthma=Yes 1.4035088 0.4571429 9.190584
## smoking_exposure_at_work=No 18.3234820 38.9714286 60.012899
## allergen_triggered_asthma=Yes 3.1971581 2.0571429 18.155434
## Breathlessness=Yes 13.8268156 22.6285714 46.178652
## familial_allergy=Yes 12.1044304 17.4857143 40.761045
## weather_triggered_asthma=Yes 0.3267974 0.2285714 19.735569
## infection_triggered_asthma=Yes 1.1925043 1.6000000 37.858755
## exertion_triggered_asthma=Yes 1.3311148 1.8285714 38.761690
## p.value v.test
## exertion_triggered_asthma=No 3.948095e-198 30.030302
## infection_triggered_asthma=No 1.304374e-194 29.759560
## weather_triggered_asthma=No 2.289165e-96 20.830529
## familial_allergy=No 4.545603e-66 17.168821
## Breathlessness=No 6.439109e-64 16.878846
## allergen_triggered_asthma=No 1.653452e-63 16.823076
## smoking_exposure_at_work=Yes 3.215820e-50 14.901641
## irritant_triggered_asthma=No 4.253908e-37 12.725746
## emotion_triggered_asthma=No 2.923510e-25 10.384285
## Gender=No 7.817728e-22 9.602304
## gina_steps=onlys saba or non users 1.066241e-21 9.570273
## smoking_status=former smokers 4.494728e-19 8.924067
## education=tertiary 1.270068e-16 8.276351
## smoking_exposure_at_home=Yes 2.944097e-16 8.175595
## Recurrent_wheeze=No 7.042324e-14 7.487079
## nasal_plyposis=Yes 1.280658e-08 5.688626
## household_damage=No 6.285241e-08 5.410490
## dyspenea=No 1.802417e-07 5.218640
## severe_asthma=No 7.229371e-07 4.955098
## smoking_status=current smoker 8.501213e-06 4.452157
## Drug_induced_dyspnea=No 2.013095e-05 4.263433
## urbanization_level=Yes 2.513083e-04 3.660923
## Cough=No 1.191153e-03 3.240990
## Ever_rhinitis=Yes 1.213335e-03 3.235727
## XCOPD=No 5.593517e-03 2.770704
## Hosptalization_last_year=Yes 8.949810e-03 2.613965
## Chronic_productive_cough=No 9.421832e-03 2.596356
## gina_control=controlled 2.079782e-02 2.311635
## Chronic_productive_cough=Yes 9.421832e-03 -2.596356
## Hosptalization_last_year=No 8.949810e-03 -2.613965
## XCOPD=Yes 5.593517e-03 -2.770704
## Ever_rhinitis=No 1.213335e-03 -3.235727
## Cough=Yes 1.191153e-03 -3.240990
## gina_steps=step4 or 5 5.386270e-04 -3.460773
## urbanization_level=No 2.513083e-04 -3.660923
## gina_steps=step3 1.330685e-04 -3.820709
## Drug_induced_dyspnea=Yes 2.013095e-05 -4.263433
## severe_asthma=Yes 7.229371e-07 -4.955098
## dyspenea=Yes 1.802417e-07 -5.218640
## household_damage=Yes 6.285241e-08 -5.410490
## nasal_plyposis=No 1.280658e-08 -5.688626
## gina_steps=step 1 or 2 1.137042e-13 -7.423920
## Recurrent_wheeze=Yes 7.042324e-14 -7.487079
## education=primary 5.808946e-14 -7.512318
## smoking_exposure_at_home=No 2.944097e-16 -8.175595
## Gender=Yes 7.817728e-22 -9.602304
## emotion_triggered_asthma=Yes 2.923510e-25 -10.384285
## smoking_status=never smoker 7.826725e-30 -11.345289
## irritant_triggered_asthma=Yes 4.253908e-37 -12.725746
## smoking_exposure_at_work=No 3.215820e-50 -14.901641
## allergen_triggered_asthma=Yes 1.653452e-63 -16.823076
## Breathlessness=Yes 6.439109e-64 -16.878846
## familial_allergy=Yes 4.545603e-66 -17.168821
## weather_triggered_asthma=Yes 2.289165e-96 -20.830529
## infection_triggered_asthma=Yes 1.304374e-194 -29.759560
## exertion_triggered_asthma=Yes 3.948095e-198 -30.030302
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.55216104 0.000000e+00
## onset_age_asthma 0.49759855 0.000000e+00
## pack_years 0.25607656 2.591724e-198
## kco 0.18677584 1.755471e-138
## tlco 0.16335275 2.049670e-119
## FEV1_FVC_ratio_post 0.16195899 2.686692e-118
## Reversibility 0.08796779 1.573566e-61
## pd20 0.07855601 1.193694e-54
## BMI 0.06259574 3.773221e-43
## Monocytes 0.04690791 4.745690e-32
## Neutrophiles 0.03435817 2.553291e-23
## FeNO 0.03337607 1.214897e-22
## Eosinophiles 0.02377057 4.595033e-16
## Basophiles 0.01050532 3.703533e-07
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 36.591010 3.761567e+01 1.277169e+01 1.803639e+01
## Age 22.968201 6.457836e+01 5.047952e+01 8.653218e+00
## pack_years 17.075367 2.026591e+01 1.128550e+01 1.658032e+01
## Reversibility 12.270002 9.176798e+00 5.948107e+00 9.357024e+00
## BMI 9.205562 2.830259e+01 2.661552e+01 4.863457e+00
## Neutrophiles 8.248393 4.194552e+00 3.757449e+00 1.498760e+00
## FeNO 7.368207 2.860019e+01 2.306080e+01 2.707771e+01
## pd20 6.409128 2.972379e+03 2.320957e+03 2.099620e+03
## Eosinophiles 6.102328 2.361194e-01 2.004192e-01 1.901900e-01
## Monocytes 4.330937 4.455037e-01 4.195937e-01 1.532220e-01
## Basophiles 4.308588 3.531716e-02 2.780071e-02 5.047066e-02
## kco -10.087606 9.142755e+01 9.737797e+01 1.635805e+01
## tlco -12.083407 9.022679e+01 9.981259e+01 2.117967e+01
## FEV1_FVC_ratio_post -18.269573 7.202862e-01 7.832420e-01 1.113194e-01
## Overall sd p.value
## onset_age_asthma 1.728090e+01 3.975223e-293
## Age 1.562341e+01 9.694240e-117
## pack_years 1.338584e+01 2.263989e-65
## Reversibility 6.697326e+00 1.312508e-34
## BMI 4.664452e+00 3.398865e-20
## Neutrophiles 1.348758e+00 1.605391e-16
## FeNO 1.913459e+01 1.729385e-13
## pd20 2.586920e+03 1.463545e-10
## Eosinophiles 1.488999e-01 1.045348e-09
## Monocytes 1.522671e-01 1.484762e-05
## Basophiles 4.440150e-02 1.643003e-05
## kco 1.501340e+01 6.267977e-24
## tlco 2.019103e+01 1.292513e-33
## FEV1_FVC_ratio_post 8.770554e-02 1.445772e-74
##
## $`1`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 17.205624 8.258597e-01 7.832420e-01 5.976555e-02
## tlco 13.618794 1.075785e+02 9.981259e+01 2.420914e+01
## kco 10.029046 1.016303e+02 9.737797e+01 1.275923e+01
## Basophiles -4.131109 2.262038e-02 2.780071e-02 4.120617e-02
## Eosinophiles -6.847576 1.716237e-01 2.004192e-01 1.218959e-01
## pd20 -6.965430 1.812067e+03 2.320957e+03 2.459397e+03
## Neutrophiles -8.227164 3.444065e+00 3.757449e+00 1.181437e+00
## FeNO -8.484191 1.847598e+01 2.306080e+01 1.233157e+01
## Monocytes -8.720229 3.820941e-01 4.195937e-01 1.476868e-01
## Reversibility -10.193174 4.020122e+00 5.948107e+00 4.008057e+00
## BMI -12.131328 2.501743e+01 2.661552e+01 4.220337e+00
## pack_years -18.323021 4.358652e+00 1.128550e+01 4.751393e+00
## onset_age_asthma -19.379663 3.313550e+00 1.277169e+01 7.639571e+00
## Age -26.780788 3.866293e+01 5.047952e+01 1.122126e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 2.409688e-66
## tlco 2.019103e+01 3.096388e-42
## kco 1.501340e+01 1.136088e-23
## Basophiles 4.440150e-02 3.610166e-05
## Eosinophiles 1.488999e-01 7.511172e-12
## pd20 2.586920e+03 3.274015e-12
## Neutrophiles 1.348758e+00 1.916973e-16
## FeNO 1.913459e+01 2.172250e-17
## Monocytes 1.522671e-01 2.776407e-18
## Reversibility 6.697326e+00 2.127048e-24
## BMI 4.664452e+00 7.207130e-34
## pack_years 1.338584e+01 5.421781e-75
## onset_age_asthma 1.728090e+01 1.145958e-83
## Age 1.562341e+01 5.410153e-158
##
## $`2`
## v.test Mean in category Overall mean sd in category
## kco 16.452328 1.049209e+02 9.737797e+01 1.296835e+01
## tlco 11.495593 1.069005e+02 9.981259e+01 1.327667e+01
## Reversibility 7.202772 7.421208e+00 5.948107e+00 7.065328e+00
## onset_age_asthma 3.680488 1.471393e+01 1.277169e+01 1.070986e+01
## Eosinophiles 3.288078 2.153701e-01 2.004192e-01 1.558593e-01
## FeNO 3.072647 2.485621e+01 2.306080e+01 1.984097e+01
## FEV1_FVC_ratio_post 2.149732 7.889996e-01 7.832420e-01 7.849388e-02
## Basophiles 2.130961 3.069009e-02 2.780071e-02 4.540519e-02
## Monocytes -4.289402 3.996487e-01 4.195937e-01 1.298165e-01
## pd20 -10.273880 1.509344e+03 2.320957e+03 2.243150e+03
## pack_years -12.705242 6.092004e+00 1.128550e+01 6.457349e+00
## Age -19.117013 4.135885e+01 5.047952e+01 1.162825e+01
## Overall sd p.value
## kco 1.501340e+01 8.070557e-61
## tlco 2.019103e+01 1.388242e-30
## Reversibility 6.697326e+00 5.900038e-13
## onset_age_asthma 1.728090e+01 2.327881e-04
## Eosinophiles 1.488999e-01 1.008738e-03
## FeNO 1.913459e+01 2.121692e-03
## FEV1_FVC_ratio_post 8.770554e-02 3.157642e-02
## Basophiles 4.440150e-02 3.309234e-02
## Monocytes 1.522671e-01 1.791547e-05
## pd20 2.586920e+03 9.241146e-25
## pack_years 1.338584e+01 5.529824e-37
## Age 1.562341e+01 1.822505e-81
##
## $`3`
## v.test Mean in category Overall mean sd in category
## Age 26.210345 62.2102857 50.4795227 9.479922e+00
## pack_years 16.425929 17.5842371 11.2855015 1.558791e+01
## pd20 11.599123 3180.5361641 2320.9569182 2.897790e+03
## Monocytes 9.299978 0.4601600 0.4195937 1.622428e-01
## BMI 5.121739 27.2999023 26.6155247 4.316431e+00
## Lymphocytes 2.315694 2.0054971 1.9624411 7.390728e-01
## FEV1_FVC_ratio_post -4.049316 0.7730681 0.7832420 7.744487e-02
## Reversibility -7.046583 4.5961664 5.9481072 5.429787e+00
## tlco -14.712309 91.3028357 99.8125910 1.324062e+01
## onset_age_asthma -14.817086 5.4365714 12.7716866 1.297678e+01
## kco -17.590119 89.8126813 97.3779717 1.289866e+01
## Overall sd p.value
## Age 1.562341e+01 2.025583e-151
## pack_years 1.338584e+01 1.247575e-60
## pd20 2.586920e+03 4.163206e-31
## Monocytes 1.522671e-01 1.404743e-20
## BMI 4.664452e+00 3.027301e-07
## Lymphocytes 6.490450e-01 2.057501e-02
## FEV1_FVC_ratio_post 8.770554e-02 5.136753e-05
## Reversibility 6.697326e+00 1.833653e-12
## tlco 2.019103e+01 5.374177e-49
## onset_age_asthma 1.728090e+01 1.136065e-49
## kco 1.501340e+01 2.932593e-691.2.3 Radar Plots
1.2.4 parallel box plots
1.2.5 parallel coordinate plot
1.3 Imporved Deep Empedding Clustering on the encoded data 3 clusters
1.3.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=575) | 1 (N=909) | 2 (N=1617) | Total (N=3101) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 63.600 (9.122) | 42.760 (13.293) | 50.153 (15.642) | 50.480 (15.626) | |
| Â Â Â Range | 37.000 - 86.000 | 17.000 - 80.000 | 17.000 - 97.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | ||||
| Â Â Â No | 216 (37.6%) | 336 (37.0%) | 782 (48.4%) | 1334 (43.0%) | |
| Â Â Â Yes | 359 (62.4%) | 573 (63.0%) | 835 (51.6%) | 1767 (57.0%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 28.378 (4.842) | 26.663 (4.958) | 25.962 (4.251) | 26.616 (4.665) | |
| Â Â Â Range | 17.668 - 48.919 | 16.534 - 50.058 | 16.975 - 48.870 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 41.449 (14.126) | 13.185 (9.577) | 2.342 (7.006) | 12.772 (17.284) | |
| Â Â Â Range | 1.000 - 72.000 | -1.000 - 48.000 | -1.000 - 42.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 297 (51.7%) | 624 (68.6%) | 1367 (84.5%) | 2288 (73.8%) | |
| Â Â Â Yes | 278 (48.3%) | 285 (31.4%) | 250 (15.5%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | ||||
| Â Â Â No | 165 (28.7%) | 182 (20.0%) | 1322 (81.8%) | 1669 (53.8%) | |
| Â Â Â Yes | 410 (71.3%) | 727 (80.0%) | 295 (18.2%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 394 (68.5%) | 711 (78.2%) | 1543 (95.4%) | 2648 (85.4%) | |
| Â Â Â Yes | 181 (31.5%) | 198 (21.8%) | 74 (4.6%) | 453 (14.6%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 350 (60.9%) | 755 (83.1%) | 1531 (94.7%) | 2636 (85.0%) | |
| Â Â Â Yes | 225 (39.1%) | 154 (16.9%) | 86 (5.3%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 375 (65.2%) | 740 (81.4%) | 1480 (91.5%) | 2595 (83.7%) | |
| Â Â Â Yes | 200 (34.8%) | 169 (18.6%) | 137 (8.5%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.727 (0.113) | 0.784 (0.083) | 0.803 (0.069) | 0.783 (0.088) | |
| Â Â Â Range | 0.230 - 1.590 | 0.259 - 1.028 | 0.387 - 1.180 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 8.693 (9.752) | 7.502 (6.858) | 4.098 (4.289) | 5.948 (6.698) | |
| Â Â Â Range | -20.000 - 77.242 | -26.774 - 53.704 | -12.603 - 38.626 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 2829.375 (2015.865) | 1613.852 (2309.409) | 2537.666 (2825.148) | 2320.957 (2587.337) | |
| Â Â Â Range | -3701.250 - 13923.750 | -6521.250 - 38775.000 | -26261.250 - 38775.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 91.063 (21.409) | 105.138 (14.024) | 99.930 (21.582) | 99.813 (20.194) | |
| Â Â Â Range | 44.477 - 389.709 | 55.302 - 161.534 | 44.453 - 680.093 | 44.453 - 680.093 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 92.382 (16.880) | 103.229 (13.651) | 95.865 (14.007) | 97.378 (15.016) | |
| Â Â Â Range | 40.972 - 140.532 | 55.075 - 149.720 | 28.161 - 141.410 | 28.161 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 25.606 (24.192) | 27.323 (23.253) | 19.760 (12.941) | 23.061 (19.138) | |
| Â Â Â Range | 3.600 - 226.000 | 3.300 - 203.000 | 0.000 - 146.650 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.229 (0.184) | 0.225 (0.163) | 0.176 (0.120) | 0.200 (0.149) | |
| Â Â Â Range | 0.000 - 2.300 | 0.000 - 1.200 | 0.000 - 0.900 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 4.111 (1.403) | 3.824 (1.412) | 3.594 (1.264) | 3.757 (1.349) | |
| Â Â Â Range | 1.300 - 11.500 | 1.000 - 12.500 | 0.700 - 11.000 | 0.700 - 12.500 | |
| Lymphocyties | 0.553 | ||||
| Â Â Â Mean (SD) | 1.980 (0.866) | 1.972 (0.590) | 1.951 (0.588) | 1.962 (0.649) | |
| Â Â Â Range | 0.300 - 11.200 | 0.400 - 5.000 | 0.300 - 4.800 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.441 (0.155) | 0.417 (0.157) | 0.413 (0.148) | 0.420 (0.152) | |
| Â Â Â Range | 0.200 - 1.100 | 0.100 - 2.400 | 0.190 - 1.500 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.038 (0.051) | 0.030 (0.045) | 0.023 (0.041) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.200 | 0.000 - 0.250 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 375 (65.2%) | 192 (21.1%) | 377 (23.3%) | 944 (30.4%) | |
| Â Â Â Yes | 200 (34.8%) | 717 (78.9%) | 1240 (76.7%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 409 (71.1%) | 338 (37.2%) | 1090 (67.4%) | 1837 (59.2%) | |
| Â Â Â Yes | 166 (28.9%) | 571 (62.8%) | 527 (32.6%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | ||||
| Â Â Â No | 535 (93.0%) | 853 (93.8%) | 1596 (98.7%) | 2984 (96.2%) | |
| Â Â Â Yes | 40 (7.0%) | 56 (6.2%) | 21 (1.3%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | ||||
| Â Â Â No | 292 (50.8%) | 555 (61.1%) | 886 (54.8%) | 1733 (55.9%) | |
| Â Â Â Yes | 283 (49.2%) | 354 (38.9%) | 731 (45.2%) | 1368 (44.1%) | |
| Ever_rhinitis | < 0.001 | ||||
| Â Â Â No | 119 (20.7%) | 312 (34.3%) | 460 (28.4%) | 891 (28.7%) | |
| Â Â Â Yes | 456 (79.3%) | 597 (65.7%) | 1157 (71.6%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | ||||
| Â Â Â onlys saba or non users | 350 (60.9%) | 562 (61.8%) | 1440 (89.1%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 113 (19.7%) | 199 (21.9%) | 97 (6.0%) | 409 (13.2%) | |
| Â Â Â step3 | 23 (4.0%) | 64 (7.0%) | 31 (1.9%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 89 (15.5%) | 84 (9.2%) | 49 (3.0%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 522 (90.8%) | 883 (97.1%) | 1533 (94.8%) | 2938 (94.7%) | |
| Â Â Â Yes | 53 (9.2%) | 26 (2.9%) | 84 (5.2%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 435 (75.7%) | 780 (85.8%) | 1425 (88.1%) | 2640 (85.1%) | |
| Â Â Â Yes | 140 (24.3%) | 129 (14.2%) | 192 (11.9%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 438 (76.2%) | 754 (82.9%) | 1516 (93.8%) | 2708 (87.3%) | |
| Â Â Â Yes | 137 (23.8%) | 155 (17.1%) | 101 (6.2%) | 393 (12.7%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 159 (27.7%) | 332 (36.5%) | 853 (52.8%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 301 (52.3%) | 453 (49.8%) | 637 (39.4%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 115 (20.0%) | 124 (13.6%) | 127 (7.9%) | 366 (11.8%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 214 (37.2%) | 508 (55.9%) | 769 (47.6%) | 1491 (48.1%) | |
| Â Â Â secondary | 226 (39.3%) | 344 (37.8%) | 652 (40.3%) | 1222 (39.4%) | |
| Â Â Â tertiary | 135 (23.5%) | 57 (6.3%) | 196 (12.1%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 355 (61.7%) | 491 (54.0%) | 538 (33.3%) | 1384 (44.6%) | |
| Â Â Â Yes | 220 (38.3%) | 418 (46.0%) | 1079 (66.7%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 230 (40.0%) | 575 (63.3%) | 877 (54.2%) | 1682 (54.2%) | |
| Â Â Â former smokers | 289 (50.3%) | 264 (29.0%) | 595 (36.8%) | 1148 (37.0%) | |
| Â Â Â current smoker | 56 (9.7%) | 70 (7.7%) | 145 (9.0%) | 271 (8.7%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 20.687 (18.295) | 7.272 (8.384) | 10.199 (11.990) | 11.286 (13.388) | |
| Â Â Â Range | 0.000 - 112.500 | 0.000 - 75.000 | 0.000 - 104.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 167 (29.0%) | 378 (41.6%) | 639 (39.5%) | 1184 (38.2%) | |
| Â Â Â Yes | 408 (71.0%) | 531 (58.4%) | 978 (60.5%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 276 (48.0%) | 619 (68.1%) | 966 (59.7%) | 1861 (60.0%) | |
| Â Â Â Yes | 299 (52.0%) | 290 (31.9%) | 651 (40.3%) | 1240 (40.0%) | |
| household_damage | 0.114 | ||||
| Â Â Â No | 516 (89.7%) | 785 (86.4%) | 1431 (88.5%) | 2732 (88.1%) | |
| Â Â Â Yes | 59 (10.3%) | 124 (13.6%) | 186 (11.5%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 184 (32.0%) | 105 (11.6%) | 1610 (99.6%) | 1899 (61.2%) | |
| Â Â Â Yes | 391 (68.0%) | 804 (88.4%) | 7 (0.4%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 172 (29.9%) | 149 (16.4%) | 1606 (99.3%) | 1927 (62.1%) | |
| Â Â Â Yes | 403 (70.1%) | 760 (83.6%) | 11 (0.7%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 442 (76.9%) | 500 (55.0%) | 1596 (98.7%) | 2538 (81.8%) | |
| Â Â Â Yes | 133 (23.1%) | 409 (45.0%) | 21 (1.3%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 491 (85.4%) | 713 (78.4%) | 1612 (99.7%) | 2816 (90.8%) | |
| Â Â Â Yes | 84 (14.6%) | 196 (21.6%) | 5 (0.3%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 372 (64.7%) | 502 (55.2%) | 1615 (99.9%) | 2489 (80.3%) | |
| Â Â Â Yes | 203 (35.3%) | 407 (44.8%) | 2 (0.1%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 512 (89.0%) | 807 (88.8%) | 1617 (100.0%) | 2936 (94.7%) | |
| Â Â Â Yes | 63 (11.0%) | 102 (11.2%) | 0 (0.0%) | 165 (5.3%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 424 (73.7%) | 842 (92.6%) | 1561 (96.5%) | 2827 (91.2%) | |
| Â Â Â Yes | 151 (26.3%) | 67 (7.4%) | 56 (3.5%) | 274 (8.8%) |
1.3.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## exertion_triggered_asthma 0.000000e+00 2
## infection_triggered_asthma 0.000000e+00 2
## Breathlessness 2.046252e-233 2
## weather_triggered_asthma 3.273155e-183 2
## allergen_triggered_asthma 1.222674e-165 2
## spt_any 1.479626e-88 2
## dyspenea 3.623232e-84 2
## irritant_triggered_asthma 1.674002e-74 2
## gina_steps 7.892598e-73 6
## Recurrent_wheeze 1.100960e-65 2
## XCOPD 6.709709e-61 2
## familial_allergy 1.652278e-57 2
## Cough 4.935229e-56 2
## Chronic_productive_cough 1.773577e-48 2
## emotion_triggered_asthma 5.687633e-42 2
## urbanization_level 6.951492e-41 2
## gina_control 1.626275e-32 4
## severe_asthma 2.766996e-31 2
## education 5.998784e-23 4
## smoking_status 1.852947e-16 4
## smoking_exposure_at_work 1.274667e-13 2
## Drug_induced_dyspnea 3.121435e-13 2
## Emergency_last_year 3.762891e-12 2
## Gender 2.782131e-09 2
## Ever_rhinitis 1.082636e-07 2
## Hosptalization_last_year 6.138791e-07 2
## smoking_exposure_at_home 2.232993e-06 2
## nasal_plyposis 2.347729e-04 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## spt_any=No 39.724576 65.217391 30.441793 4.917475e-83
## infection_triggered_asthma=Yes 34.327087 70.086957 37.858755 4.819862e-68
## dyspenea=Yes 48.387097 39.130435 14.995163 1.686584e-59
## exertion_triggered_asthma=Yes 32.529118 68.000000 38.761690 5.453753e-56
## XCOPD=Yes 55.109489 26.260870 8.835859 7.557523e-47
## Breathlessness=Yes 28.631285 71.304348 46.178652 1.956830e-41
## Cough=Yes 34.194342 48.347826 26.217349 2.676085e-37
## Chronic_productive_cough=Yes 39.525692 34.782609 16.317317 1.153959e-34
## Recurrent_wheeze=Yes 39.955850 31.478261 14.608191 1.472394e-31
## weather_triggered_asthma=Yes 33.169935 35.304348 19.735569 8.593302e-23
## urbanization_level=No 25.650289 61.739130 44.630764 7.406858e-20
## severe_asthma=Yes 34.860051 23.826087 12.673331 1.080620e-16
## education=tertiary 34.793814 23.478261 12.512093 2.372870e-16
## gina_steps=step4 or 5 40.090090 15.478261 7.158981 6.428936e-15
## smoking_status=former smokers 25.174216 50.260870 37.020316 6.799115e-13
## Emergency_last_year=Yes 30.368764 24.347826 14.866172 1.908051e-11
## familial_allergy=No 22.264562 71.130435 59.238955 6.698546e-11
## smoking_exposure_at_work=Yes 24.112903 52.000000 39.987101 1.087905e-10
## gina_control=uncontrolled 31.420765 20.000000 11.802644 2.086781e-10
## emotion_triggered_asthma=Yes 38.181818 10.956522 5.320864 1.157096e-09
## smoking_exposure_at_home=Yes 21.283255 70.956522 61.818768 4.120650e-07
## gina_steps=step 1 or 2 27.628362 19.652174 13.189294 1.204210e-06
## Ever_rhinitis=Yes 20.633484 79.304348 71.267333 1.370722e-06
## irritant_triggered_asthma=Yes 29.473684 14.608696 9.190584 2.401142e-06
## Hosptalization_last_year=Yes 32.515337 9.217391 5.256369 1.116747e-05
## Drug_induced_dyspnea=Yes 34.188034 6.956522 3.772976 4.101578e-05
## gina_control=partially controlled 21.639109 52.347826 44.856498 6.648332e-05
## allergen_triggered_asthma=Yes 23.623446 23.130435 18.155434 8.130528e-04
## Gender=Yes 20.316921 62.434783 56.981619 3.326823e-03
## nasal_plyposis=Yes 20.687135 49.217391 44.114802 6.493058e-03
## nasal_plyposis=No 16.849394 50.782609 55.885198 6.493058e-03
## Gender=No 16.191904 37.565217 43.018381 3.326823e-03
## allergen_triggered_asthma=No 17.415288 76.869565 81.844566 8.130528e-04
## Drug_induced_dyspnea=No 17.928954 93.043478 96.227024 4.101578e-05
## Hosptalization_last_year=No 17.767189 90.782609 94.743631 1.116747e-05
## irritant_triggered_asthma=No 17.436080 85.391304 90.809416 2.401142e-06
## Ever_rhinitis=No 13.355780 20.695652 28.732667 1.370722e-06
## smoking_exposure_at_home=No 14.104730 29.043478 38.181232 4.120650e-07
## education=primary 14.352783 37.217391 48.081264 6.564545e-09
## emotion_triggered_asthma=No 17.438692 89.043478 94.679136 1.157096e-09
## smoking_exposure_at_work=No 14.830736 48.000000 60.012899 1.087905e-10
## familial_allergy=Yes 13.132911 28.869565 40.761045 6.698546e-11
## Emergency_last_year=No 16.477273 75.652174 85.133828 1.908051e-11
## smoking_status=never smoker 13.674197 40.000000 54.240568 3.412653e-14
## severe_asthma=No 16.174298 76.173913 87.326669 1.080620e-16
## gina_control=controlled 11.830357 27.652174 43.340858 1.114267e-17
## gina_steps=onlys saba or non users 14.880952 60.869565 75.846501 4.587930e-19
## urbanization_level=Yes 12.813046 38.260870 55.369236 7.406858e-20
## weather_triggered_asthma=No 14.945761 64.695652 80.264431 8.593302e-23
## Recurrent_wheeze=No 14.879154 68.521739 85.391809 1.472394e-31
## Chronic_productive_cough=No 14.450867 65.217391 83.682683 1.153959e-34
## Cough=No 12.980769 51.652174 73.782651 2.676085e-37
## Breathlessness=No 9.886159 28.695652 53.821348 1.956830e-41
## XCOPD=No 14.998231 73.739130 91.164141 7.557523e-47
## exertion_triggered_asthma=No 9.689310 32.000000 61.238310 5.453753e-56
## dyspenea=No 13.277693 60.869565 85.004837 1.686584e-59
## infection_triggered_asthma=No 8.925791 29.913043 62.141245 4.819862e-68
## spt_any=Yes 9.272137 34.782609 69.558207 4.917475e-83
## v.test
## spt_any=No 19.304557
## infection_triggered_asthma=Yes 17.430763
## dyspenea=Yes 16.267214
## exertion_triggered_asthma=Yes 15.764576
## XCOPD=Yes 14.373794
## Breathlessness=Yes 13.483470
## Cough=Yes 12.761896
## Chronic_productive_cough=Yes 12.280421
## Recurrent_wheeze=Yes 11.687748
## weather_triggered_asthma=Yes 9.827250
## urbanization_level=No 9.121534
## severe_asthma=Yes 8.295574
## education=tertiary 8.201560
## gina_steps=step4 or 5 7.795234
## smoking_status=former smokers 7.183415
## Emergency_last_year=Yes 6.712891
## familial_allergy=No 6.527256
## smoking_exposure_at_work=Yes 6.454202
## gina_control=uncontrolled 6.354815
## emotion_triggered_asthma=Yes 6.086079
## smoking_exposure_at_home=Yes 5.063298
## gina_steps=step 1 or 2 4.854944
## Ever_rhinitis=Yes 4.829215
## irritant_triggered_asthma=Yes 4.716349
## Hosptalization_last_year=Yes 4.393238
## Drug_induced_dyspnea=Yes 4.101682
## gina_control=partially controlled 3.988532
## allergen_triggered_asthma=Yes 3.348312
## Gender=Yes 2.935806
## nasal_plyposis=Yes 2.721784
## nasal_plyposis=No -2.721784
## Gender=No -2.935806
## allergen_triggered_asthma=No -3.348312
## Drug_induced_dyspnea=No -4.101682
## Hosptalization_last_year=No -4.393238
## irritant_triggered_asthma=No -4.716349
## Ever_rhinitis=No -4.829215
## smoking_exposure_at_home=No -5.063298
## education=primary -5.801701
## emotion_triggered_asthma=No -6.086079
## smoking_exposure_at_work=No -6.454202
## familial_allergy=Yes -6.527256
## Emergency_last_year=No -6.712891
## smoking_status=never smoker -7.581621
## severe_asthma=No -8.295574
## gina_control=controlled -8.561481
## gina_steps=onlys saba or non users -8.921794
## urbanization_level=Yes -9.121534
## weather_triggered_asthma=No -9.827250
## Recurrent_wheeze=No -11.687748
## Chronic_productive_cough=No -12.280421
## Cough=No -12.761896
## Breathlessness=No -13.483470
## XCOPD=No -14.373794
## exertion_triggered_asthma=No -15.764576
## dyspenea=No -16.267214
## infection_triggered_asthma=No -17.430763
## spt_any=Yes -19.304557
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 66.888519 88.448845 38.761690 8.535119e-309
## infection_triggered_asthma=Yes 64.735945 83.608361 37.858755 6.145383e-258
## Breathlessness=Yes 50.768156 79.977998 46.178652 5.726335e-136
## allergen_triggered_asthma=Yes 72.646536 44.994499 18.155434 3.078823e-126
## weather_triggered_asthma=Yes 66.503268 44.774477 19.735569 9.280067e-104
## familial_allergy=Yes 45.174051 62.816282 40.761045 7.912171e-58
## irritant_triggered_asthma=Yes 68.771930 21.562156 9.190584 1.061966e-47
## emotion_triggered_asthma=Yes 61.818182 11.221122 5.320864 6.119156e-19
## gina_steps=step 1 or 2 48.655257 21.892189 13.189294 7.208538e-19
## spt_any=Yes 33.240612 78.877888 69.558207 1.250572e-13
## Recurrent_wheeze=Yes 43.708609 21.782178 14.608191 1.636595e-12
## urbanization_level=No 35.476879 54.015402 44.630764 1.444451e-11
## smoking_status=never smoker 34.185493 63.256326 54.240568 7.153463e-11
## smoking_exposure_at_work=No 33.261687 68.096810 60.012899 2.479038e-09
## gina_steps=step3 54.237288 7.040704 3.805224 9.078366e-09
## education=primary 34.071093 55.885589 48.081264 2.154825e-08
## severe_asthma=Yes 39.440204 17.051705 12.673331 4.093403e-06
## Gender=Yes 32.427844 63.036304 56.981619 1.081345e-05
## Ever_rhinitis=No 35.016835 34.323432 28.732667 1.156334e-05
## Drug_induced_dyspnea=Yes 47.863248 6.160616 3.772976 1.732596e-05
## Cough=Yes 35.055351 31.353135 26.217349 3.452739e-05
## Hosptalization_last_year=No 30.054459 97.139714 94.743631 5.399636e-05
## nasal_plyposis=No 32.025389 61.056106 55.885198 1.822060e-04
## gina_control=partially controlled 32.566499 49.834983 44.856498 3.405967e-04
## gina_steps=step4 or 5 37.837838 9.240924 7.158981 4.623507e-03
## smoking_exposure_at_home=No 31.925676 41.584158 38.181232 1.229767e-02
## Chronic_productive_cough=Yes 33.399209 18.591859 16.317317 2.875828e-02
## gina_control=uncontrolled 33.879781 13.641364 11.802644 4.322413e-02
## Chronic_productive_cough=No 28.516378 81.408141 83.682683 2.875828e-02
## smoking_exposure_at_home=Yes 27.699531 58.415842 61.818768 1.229767e-02
## nasal_plyposis=Yes 25.877193 38.943894 44.114802 1.822060e-04
## Hosptalization_last_year=Yes 15.950920 2.860286 5.256369 5.399636e-05
## Cough=No 27.272727 68.646865 73.782651 3.452739e-05
## Drug_induced_dyspnea=No 28.585791 93.839384 96.227024 1.732596e-05
## Ever_rhinitis=Yes 27.013575 65.676568 71.267333 1.156334e-05
## Gender=No 25.187406 36.963696 43.018381 1.081345e-05
## severe_asthma=No 27.843427 82.948295 87.326669 4.093403e-06
## gina_control=controlled 24.702381 36.523652 43.340858 7.321111e-07
## smoking_exposure_at_work=Yes 23.387097 31.903190 39.987101 2.479038e-09
## smoking_status=former smokers 22.996516 29.042904 37.020316 2.190578e-09
## urbanization_level=Yes 24.344787 45.984598 55.369236 1.444451e-11
## Recurrent_wheeze=No 26.850453 78.217822 85.391809 1.636595e-12
## education=tertiary 14.690722 6.270627 12.512093 9.124472e-13
## spt_any=No 20.338983 21.122112 30.441793 1.250572e-13
## emotion_triggered_asthma=No 27.486376 88.778878 94.679136 6.119156e-19
## gina_steps=onlys saba or non users 23.894558 61.826183 75.846501 2.805168e-30
## irritant_triggered_asthma=No 25.319602 78.437844 90.809416 1.061966e-47
## familial_allergy=No 18.399565 37.183718 59.238955 7.912171e-58
## weather_triggered_asthma=No 20.168742 55.225523 80.264431 9.280067e-104
## allergen_triggered_asthma=No 19.700552 55.005501 81.844566 3.078823e-126
## Breathlessness=No 10.904733 20.022002 53.821348 5.726335e-136
## infection_triggered_asthma=No 7.732226 16.391639 62.141245 6.145383e-258
## exertion_triggered_asthma=No 5.529226 11.551155 61.238310 8.535119e-309
## v.test
## exertion_triggered_asthma=Yes 37.563335
## infection_triggered_asthma=Yes 34.307121
## Breathlessness=Yes 24.818039
## allergen_triggered_asthma=Yes 23.899781
## weather_triggered_asthma=Yes 21.630486
## familial_allergy=Yes 16.029812
## irritant_triggered_asthma=Yes 14.509040
## emotion_triggered_asthma=Yes 8.889850
## gina_steps=step 1 or 2 8.871626
## spt_any=Yes 7.411311
## Recurrent_wheeze=Yes 7.062393
## urbanization_level=No 6.753375
## smoking_status=never smoker 6.517404
## smoking_exposure_at_work=No 5.962832
## gina_steps=step3 5.747106
## education=primary 5.599088
## severe_asthma=Yes 4.606583
## Gender=Yes 4.400233
## Ever_rhinitis=No 4.385662
## Drug_induced_dyspnea=Yes 4.296828
## Cough=Yes 4.141346
## Hosptalization_last_year=No 4.037619
## nasal_plyposis=No 3.742490
## gina_control=partially controlled 3.582289
## gina_steps=step4 or 5 2.832157
## smoking_exposure_at_home=No 2.503486
## Chronic_productive_cough=Yes 2.186784
## gina_control=uncontrolled 2.021538
## Chronic_productive_cough=No -2.186784
## smoking_exposure_at_home=Yes -2.503486
## nasal_plyposis=Yes -3.742490
## Hosptalization_last_year=Yes -4.037619
## Cough=No -4.141346
## Drug_induced_dyspnea=No -4.296828
## Ever_rhinitis=Yes -4.385662
## Gender=No -4.400233
## severe_asthma=No -4.606583
## gina_control=controlled -4.952646
## smoking_exposure_at_work=Yes -5.962832
## smoking_status=former smokers -5.983005
## urbanization_level=Yes -6.753375
## Recurrent_wheeze=No -7.062393
## education=tertiary -7.143107
## spt_any=No -7.411311
## emotion_triggered_asthma=No -8.889850
## gina_steps=onlys saba or non users -11.434696
## irritant_triggered_asthma=No -14.509040
## familial_allergy=No -16.029812
## weather_triggered_asthma=No -21.630486
## allergen_triggered_asthma=No -23.899781
## Breathlessness=No -24.818039
## infection_triggered_asthma=No -34.307121
## exertion_triggered_asthma=No -37.563335
##
## $`2`
## Cla/Mod Mod/Cla Global
## infection_triggered_asthma=No 83.3419824 99.3197279 62.141245
## exertion_triggered_asthma=No 84.7814639 99.5670996 61.238310
## Breathlessness=No 79.2091072 81.7563389 53.821348
## weather_triggered_asthma=No 64.8854962 99.8763142 80.264431
## allergen_triggered_asthma=No 62.8841608 98.7012987 81.844566
## irritant_triggered_asthma=No 57.2443182 99.6907854 90.809416
## gina_steps=onlys saba or non users 61.2244898 89.0538033 75.846501
## Recurrent_wheeze=No 58.2703927 95.4236240 85.391809
## dyspenea=No 58.0804249 94.6815090 85.004837
## emotion_triggered_asthma=No 55.0749319 100.0000000 94.679136
## Cough=No 59.7465035 84.5392703 73.782651
## urbanization_level=Yes 62.8421666 66.7285096 55.369236
## Chronic_productive_cough=No 57.0327553 91.5275201 83.682683
## severe_asthma=No 55.9822747 93.7538652 87.326669
## XCOPD=No 55.2175451 96.5367965 91.164141
## gina_control=controlled 63.4672619 52.7520099 43.340858
## familial_allergy=No 59.3358737 67.4087817 59.238955
## spt_any=Yes 57.4872508 76.6852195 69.558207
## Drug_induced_dyspnea=No 53.4852547 98.7012987 96.227024
## Gender=No 58.6206897 48.3611626 43.018381
## Emergency_last_year=No 53.9772727 88.1261596 85.133828
## Emergency_last_year=Yes 41.6485900 11.8738404 14.866172
## gina_steps=step3 26.2711864 1.9171305 3.805224
## Gender=Yes 47.2552349 51.6388374 56.981619
## gina_control=partially controlled 45.7943925 39.3939394 44.856498
## gina_control=uncontrolled 34.6994536 7.8540507 11.802644
## Drug_induced_dyspnea=Yes 17.9487179 1.2987013 3.772976
## spt_any=No 39.9364407 23.3147805 30.441793
## gina_steps=step4 or 5 22.0720721 3.0303030 7.158981
## familial_allergy=Yes 41.6930380 32.5912183 40.761045
## XCOPD=Yes 20.4379562 3.4632035 8.835859
## severe_asthma=Yes 25.6997455 6.2461348 12.673331
## Chronic_productive_cough=Yes 27.0750988 8.4724799 16.317317
## gina_steps=step 1 or 2 23.7163814 5.9987631 13.189294
## urbanization_level=No 38.8728324 33.2714904 44.630764
## Cough=Yes 30.7503075 15.4607297 26.217349
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## dyspenea=Yes 18.4946237 5.3184910 14.995163
## Recurrent_wheeze=Yes 16.3355408 4.5763760 14.608191
## irritant_triggered_asthma=Yes 1.7543860 0.3092146 9.190584
## allergen_triggered_asthma=Yes 3.7300178 1.2987013 18.155434
## weather_triggered_asthma=Yes 0.3267974 0.1236858 19.735569
## Breathlessness=Yes 20.6005587 18.2436611 46.178652
## infection_triggered_asthma=Yes 0.9369676 0.6802721 37.858755
## exertion_triggered_asthma=Yes 0.5823627 0.4329004 38.761690
## p.value v.test
## infection_triggered_asthma=No 0.000000e+00 Inf
## exertion_triggered_asthma=No 0.000000e+00 Inf
## Breathlessness=No 1.885278e-247 33.596528
## weather_triggered_asthma=No 5.154130e-227 32.166732
## allergen_triggered_asthma=No 5.181630e-168 27.627641
## irritant_triggered_asthma=No 6.028560e-88 19.880289
## gina_steps=onlys saba or non users 2.825767e-74 18.232965
## Recurrent_wheeze=No 3.302997e-65 17.053308
## dyspenea=No 6.311814e-59 16.186190
## emotion_triggered_asthma=No 1.008167e-55 15.725709
## Cough=No 1.607452e-46 14.321445
## urbanization_level=Yes 1.522435e-40 13.331289
## Chronic_productive_cough=No 9.128185e-36 12.484001
## severe_asthma=No 5.003543e-30 11.384358
## XCOPD=No 2.000148e-29 11.262922
## gina_control=controlled 1.563234e-28 11.080314
## familial_allergy=No 3.787228e-22 9.676706
## spt_any=Yes 2.018274e-19 9.012274
## Drug_induced_dyspnea=No 8.588321e-15 7.758583
## Gender=No 3.417302e-10 6.278557
## Emergency_last_year=No 1.027695e-06 4.886260
## Emergency_last_year=Yes 1.027695e-06 -4.886260
## gina_steps=step3 6.747146e-09 -5.797100
## Gender=Yes 3.417302e-10 -6.278557
## gina_control=partially controlled 1.709770e-10 -6.385376
## gina_control=uncontrolled 9.572300e-13 -7.136521
## Drug_induced_dyspnea=Yes 8.588321e-15 -7.758583
## spt_any=No 2.018274e-19 -9.012274
## gina_steps=step4 or 5 2.207845e-21 -9.494729
## familial_allergy=Yes 3.787228e-22 -9.676706
## XCOPD=Yes 2.000148e-29 -11.262922
## severe_asthma=Yes 5.003543e-30 -11.384358
## Chronic_productive_cough=Yes 9.128185e-36 -12.484001
## gina_steps=step 1 or 2 3.417961e-36 -12.561952
## urbanization_level=No 1.522435e-40 -13.331289
## Cough=Yes 1.607452e-46 -14.321445
## emotion_triggered_asthma=Yes 1.008167e-55 -15.725709
## dyspenea=Yes 6.311814e-59 -16.186190
## Recurrent_wheeze=Yes 3.302997e-65 -17.053308
## irritant_triggered_asthma=Yes 6.028560e-88 -19.880289
## allergen_triggered_asthma=Yes 5.181630e-168 -27.627641
## weather_triggered_asthma=Yes 5.154130e-227 -32.166732
## Breathlessness=Yes 1.885278e-247 -33.596528
## infection_triggered_asthma=Yes 0.000000e+00 -Inf
## exertion_triggered_asthma=Yes 0.000000e+00 -Inf
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## onset_age_asthma 0.700732185 0.000000e+00
## Age 0.202559137 5.382143e-153
## pack_years 0.121262571 1.090900e-87
## FEV1_FVC_ratio_post 0.102255571 2.713696e-73
## Reversibility 0.086723467 9.396376e-62
## kco 0.070353195 8.405294e-50
## tlco 0.055228298 6.044107e-39
## BMI 0.036724372 6.755167e-26
## FeNO 0.033338190 1.549871e-23
## pd20 0.032722399 4.156251e-23
## Eosinophiles 0.029016744 1.552340e-20
## Neutrophiles 0.021122806 4.345081e-15
## Basophiles 0.018372362 3.353962e-13
## Monocytes 0.004554582 8.492446e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 44.082431 4.144870e+01 1.277169e+01 1.411359e+01
## Age 22.308579 6.360000e+01 5.047952e+01 9.113583e+00
## pack_years 18.657342 2.068701e+01 1.128550e+01 1.827929e+01
## Reversibility 10.889015 8.693421e+00 5.948107e+00 9.743410e+00
## BMI 10.036695 2.837788e+01 2.661552e+01 4.837879e+00
## Neutrophiles 6.968279 4.111252e+00 3.757449e+00 1.402154e+00
## Basophiles 6.351689 3.841739e-02 2.780071e-02 5.079301e-02
## pd20 5.220783 2.829375e+03 2.320957e+03 2.014111e+03
## Eosinophiles 5.181135 2.294609e-01 2.004192e-01 1.838247e-01
## Monocytes 3.708725 4.408522e-01 4.195937e-01 1.544408e-01
## FeNO 3.533099 2.560574e+01 2.306080e+01 2.417061e+01
## kco -8.839875 9.238192e+01 9.737797e+01 1.686496e+01
## tlco -11.511575 9.106285e+01 9.981259e+01 2.139068e+01
## FEV1_FVC_ratio_post -17.074393 7.268686e-01 7.832420e-01 1.128903e-01
## Overall sd p.value
## onset_age_asthma 1.728090e+01 0.000000e+00
## Age 1.562341e+01 3.050304e-110
## pack_years 1.338584e+01 1.100716e-77
## Reversibility 6.697326e+00 1.300387e-27
## BMI 4.664452e+00 1.051378e-23
## Neutrophiles 1.348758e+00 3.208420e-12
## Basophiles 4.440150e-02 2.129632e-10
## pd20 2.586920e+03 1.781679e-07
## Eosinophiles 1.488999e-01 2.205400e-07
## Monocytes 1.522671e-01 2.083056e-04
## FeNO 1.913459e+01 4.107188e-04
## kco 1.501340e+01 9.582548e-19
## tlco 2.019103e+01 1.153518e-30
## FEV1_FVC_ratio_post 8.770554e-02 2.302059e-65
##
## $`1`
## v.test Mean in category Overall mean sd in category
## kco 13.973880 103.2292882 97.3779717 13.643679
## tlco 9.456202 105.1377519 99.8125910 14.016063
## Reversibility 8.320078 7.5022334 5.9481072 6.854685
## FeNO 7.985770 27.3226073 23.0608030 23.240616
## Eosinophiles 5.967943 0.2252035 0.2004192 0.163309
## pd20 -9.800392 1613.8517914 2320.9569182 2308.138035
## pack_years -10.751427 7.2715759 11.2855015 8.379855
## Age -17.715248 42.7601760 50.4795227 13.285546
## Overall sd p.value
## kco 15.0134018 2.250270e-44
## tlco 20.1910322 3.193322e-21
## Reversibility 6.6973257 8.790564e-17
## FeNO 19.1345916 1.396474e-15
## Eosinophiles 0.1488999 2.402626e-09
## pd20 2586.9202764 1.121494e-22
## pack_years 13.3858429 5.835194e-27
## Age 15.6234094 3.198124e-70
##
## $`2`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 12.878837 8.026770e-01 7.832420e-01 6.943641e-02
## pd20 4.868697 2.537666e+03 2.320957e+03 2.824274e+03
## Monocytes -2.370639 4.133828e-01 4.195937e-01 1.483098e-01
## pack_years -4.718307 1.019879e+01 1.128550e+01 1.198596e+01
## kco -5.856076 9.586522e+01 9.737797e+01 1.400242e+01
## Basophiles -6.697512 2.268398e-02 2.780071e-02 4.055850e-02
## Neutrophiles -7.037779 3.594125e+00 3.757449e+00 1.263430e+00
## BMI -8.138399 2.596236e+01 2.661552e+01 4.250177e+00
## Eosinophiles -9.469111 1.761596e-01 2.004192e-01 1.194837e-01
## FeNO -10.025656 1.976005e+01 2.306080e+01 1.293687e+01
## Reversibility -16.053179 4.098227e+00 5.948107e+00 4.288036e+00
## onset_age_asthma -35.077134 2.341991e+00 1.277169e+01 7.003748e+00
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 5.922143e-38
## pd20 2.586920e+03 1.123364e-06
## Monocytes 1.522671e-01 1.775735e-02
## pack_years 1.338584e+01 2.378157e-06
## kco 1.501340e+01 4.739302e-09
## Basophiles 4.440150e-02 2.119984e-11
## Neutrophiles 1.348758e+00 1.953280e-12
## BMI 4.664452e+00 4.005381e-16
## Eosinophiles 1.488999e-01 2.822348e-21
## FeNO 1.913459e+01 1.175762e-23
## Reversibility 6.697326e+00 5.430978e-58
## onset_age_asthma 1.728090e+01 1.504654e-2691.3.3 Radar Plots
1.3.4 parallel box plots
1.3.5 parallel coordinate plot
1.4 Deep Empedding Clustering on the encoded data 6 clusters
1.4.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=769) | 1 (N=317) | 2 (N=603) | 3 (N=716) | 4 (N=258) | 5 (N=438) | Total (N=3101) | p value | |
|---|---|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||||
| Â Â Â Mean (SD) | 38.003 (10.791) | 64.767 (9.056) | 40.468 (13.040) | 61.204 (10.075) | 48.647 (14.752) | 59.377 (10.474) | 50.480 (15.626) | |
| Â Â Â Range | 17.000 - 72.000 | 37.000 - 86.000 | 17.000 - 86.000 | 31.000 - 97.000 | 18.000 - 82.000 | 26.000 - 85.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | |||||||
| Â Â Â No | 323 (42.0%) | 120 (37.9%) | 195 (32.3%) | 383 (53.5%) | 139 (53.9%) | 174 (39.7%) | 1334 (43.0%) | |
| Â Â Â Yes | 446 (58.0%) | 197 (62.1%) | 408 (67.7%) | 333 (46.5%) | 119 (46.1%) | 264 (60.3%) | 1767 (57.0%) | |
| BMI | < 0.001 | |||||||
| Â Â Â Mean (SD) | 24.809 (3.856) | 29.241 (5.288) | 26.108 (4.621) | 26.852 (4.089) | 26.078 (4.282) | 28.517 (5.050) | 26.616 (4.665) | |
| Â Â Â Range | 16.975 - 40.615 | 18.825 - 50.058 | 16.534 - 42.595 | 17.296 - 44.816 | 18.084 - 45.435 | 17.603 - 48.919 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||||
| Â Â Â Mean (SD) | 2.645 (7.063) | 27.148 (21.266) | 14.692 (12.026) | 1.346 (6.192) | 21.562 (17.917) | 31.002 (18.043) | 12.772 (17.284) | |
| Â Â Â Range | -1.000 - 45.000 | -1.000 - 70.000 | -1.000 - 70.000 | -1.000 - 38.000 | -1.000 - 70.000 | -1.000 - 72.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||||
| Â Â Â No | 669 (87.0%) | 162 (51.1%) | 406 (67.3%) | 604 (84.4%) | 195 (75.6%) | 252 (57.5%) | 2288 (73.8%) | |
| Â Â Â Yes | 100 (13.0%) | 155 (48.9%) | 197 (32.7%) | 112 (15.6%) | 63 (24.4%) | 186 (42.5%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | |||||||
| Â Â Â No | 635 (82.6%) | 86 (27.1%) | 168 (27.9%) | 615 (85.9%) | 32 (12.4%) | 133 (30.4%) | 1669 (53.8%) | |
| Â Â Â Yes | 134 (17.4%) | 231 (72.9%) | 435 (72.1%) | 101 (14.1%) | 226 (87.6%) | 305 (69.6%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | |||||||
| Â Â Â No | 744 (96.7%) | 190 (59.9%) | 508 (84.2%) | 693 (96.8%) | 183 (70.9%) | 330 (75.3%) | 2648 (85.4%) | |
| Â Â Â Yes | 25 (3.3%) | 127 (40.1%) | 95 (15.8%) | 23 (3.2%) | 75 (29.1%) | 108 (24.7%) | 453 (14.6%) | |
| dyspenea | < 0.001 | |||||||
| Â Â Â No | 742 (96.5%) | 176 (55.5%) | 505 (83.7%) | 673 (94.0%) | 230 (89.1%) | 310 (70.8%) | 2636 (85.0%) | |
| Â Â Â Yes | 27 (3.5%) | 141 (44.5%) | 98 (16.3%) | 43 (6.0%) | 28 (10.9%) | 128 (29.2%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | |||||||
| Â Â Â No | 736 (95.7%) | 213 (67.2%) | 495 (82.1%) | 639 (89.2%) | 207 (80.2%) | 305 (69.6%) | 2595 (83.7%) | |
| Â Â Â Yes | 33 (4.3%) | 104 (32.8%) | 108 (17.9%) | 77 (10.8%) | 51 (19.8%) | 133 (30.4%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.831 (0.056) | 0.713 (0.116) | 0.796 (0.086) | 0.786 (0.060) | 0.746 (0.096) | 0.751 (0.091) | 0.783 (0.088) | |
| Â Â Â Range | 0.596 - 1.180 | 0.267 - 1.590 | 0.259 - 1.009 | 0.557 - 1.009 | 0.424 - 1.005 | 0.230 - 1.028 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||||
| Â Â Â Mean (SD) | 3.836 (3.286) | 7.035 (8.041) | 6.489 (5.982) | 3.983 (4.460) | 13.812 (11.297) | 6.707 (6.568) | 5.948 (6.698) | |
| Â Â Â Range | -3.924 - 20.891 | -6.858 - 47.541 | -9.470 - 55.102 | -12.603 - 38.626 | -12.121 - 77.242 | -26.774 - 30.890 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||||
| Â Â Â Mean (SD) | 1925.944 (2789.571) | 2904.420 (2154.145) | 1848.170 (2539.792) | 3182.164 (2826.197) | 1420.629 (1622.955) | 2365.611 (2104.148) | 2320.957 (2587.337) | |
| Â Â Â Range | -26261.250 - 25908.750 | -1417.620 - 13923.750 | -6521.250 - 38775.000 | 0.000 - 38775.000 | 0.000 - 9693.750 | -3701.250 - 13923.750 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||||
| Â Â Â Mean (SD) | 107.450 (13.758) | 85.872 (17.895) | 105.474 (14.944) | 92.232 (12.357) | 109.573 (42.565) | 95.341 (15.732) | 99.813 (20.194) | |
| Â Â Â Range | 66.823 - 230.491 | 44.453 - 264.519 | 44.477 - 161.534 | 48.844 - 141.333 | 67.966 - 680.093 | 48.917 - 165.714 | 44.453 - 680.093 | |
| kco | < 0.001 | |||||||
| Â Â Â Mean (SD) | 102.726 (11.936) | 86.737 (15.197) | 104.179 (14.322) | 89.636 (11.878) | 103.270 (14.231) | 95.513 (15.202) | 97.378 (15.016) | |
| Â Â Â Range | 68.839 - 139.983 | 43.704 - 128.004 | 40.972 - 149.720 | 28.161 - 132.696 | 43.704 - 141.410 | 51.449 - 136.627 | 28.161 - 149.720 | |
| FeNO | < 0.001 | |||||||
| Â Â Â Mean (SD) | 17.588 (9.243) | 18.078 (12.146) | 19.388 (9.623) | 19.870 (10.068) | 65.412 (34.797) | 21.602 (12.990) | 23.061 (19.138) | |
| Â Â Â Range | 0.000 - 56.900 | 4.600 - 102.900 | 3.300 - 57.000 | 3.400 - 73.900 | 5.000 - 226.000 | 3.600 - 82.800 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.157 (0.109) | 0.222 (0.132) | 0.178 (0.116) | 0.178 (0.108) | 0.420 (0.253) | 0.199 (0.124) | 0.200 (0.149) | |
| Â Â Â Range | 0.000 - 0.800 | 0.000 - 0.800 | 0.000 - 0.700 | 0.000 - 0.810 | 0.000 - 2.300 | 0.020 - 0.800 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 3.348 (1.131) | 4.640 (1.624) | 3.666 (1.315) | 3.775 (1.310) | 3.509 (1.145) | 4.080 (1.336) | 3.757 (1.349) | |
| Â Â Â Range | 0.700 - 10.800 | 1.300 - 12.300 | 1.100 - 12.500 | 1.500 - 11.000 | 1.000 - 8.200 | 1.300 - 10.000 | 0.700 - 12.500 | |
| Lymphocyties | < 0.001 | |||||||
| Â Â Â Mean (SD) | 1.909 (0.524) | 2.101 (0.710) | 1.959 (0.762) | 1.944 (0.608) | 1.974 (0.619) | 1.983 (0.701) | 1.962 (0.649) | |
| Â Â Â Range | 0.300 - 4.000 | 0.300 - 5.400 | 0.600 - 11.200 | 0.400 - 4.800 | 0.700 - 5.000 | 0.400 - 8.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.371 (0.124) | 0.517 (0.196) | 0.390 (0.130) | 0.439 (0.142) | 0.428 (0.132) | 0.440 (0.174) | 0.420 (0.152) | |
| Â Â Â Range | 0.190 - 1.000 | 0.200 - 1.500 | 0.100 - 1.000 | 0.190 - 1.000 | 0.200 - 1.000 | 0.200 - 2.400 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | |||||||
| Â Â Â Mean (SD) | 0.015 (0.034) | 0.050 (0.053) | 0.024 (0.042) | 0.024 (0.041) | 0.045 (0.052) | 0.035 (0.047) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.190 | 0.000 - 0.300 | 0.000 - 0.200 | 0.000 - 0.250 | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||||
| Â Â Â No | 171 (22.2%) | 138 (43.5%) | 192 (31.8%) | 164 (22.9%) | 63 (24.4%) | 216 (49.3%) | 944 (30.4%) | |
| Â Â Â Yes | 598 (77.8%) | 179 (56.5%) | 411 (68.2%) | 552 (77.1%) | 195 (75.6%) | 222 (50.7%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | |||||||
| Â Â Â No | 426 (55.4%) | 243 (76.7%) | 205 (34.0%) | 562 (78.5%) | 127 (49.2%) | 274 (62.6%) | 1837 (59.2%) | |
| Â Â Â Yes | 343 (44.6%) | 74 (23.3%) | 398 (66.0%) | 154 (21.5%) | 131 (50.8%) | 164 (37.4%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | |||||||
| Â Â Â No | 763 (99.2%) | 293 (92.4%) | 573 (95.0%) | 709 (99.0%) | 250 (96.9%) | 396 (90.4%) | 2984 (96.2%) | |
| Â Â Â Yes | 6 (0.8%) | 24 (7.6%) | 30 (5.0%) | 7 (1.0%) | 8 (3.1%) | 42 (9.6%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | |||||||
| Â Â Â No | 467 (60.7%) | 159 (50.2%) | 382 (63.3%) | 350 (48.9%) | 122 (47.3%) | 253 (57.8%) | 1733 (55.9%) | |
| Â Â Â Yes | 302 (39.3%) | 158 (49.8%) | 221 (36.7%) | 366 (51.1%) | 136 (52.7%) | 185 (42.2%) | 1368 (44.1%) | |
| Ever_rhinitis | 0.004 | |||||||
| Â Â Â No | 243 (31.6%) | 83 (26.2%) | 169 (28.0%) | 179 (25.0%) | 95 (36.8%) | 122 (27.9%) | 891 (28.7%) | |
| Â Â Â Yes | 526 (68.4%) | 234 (73.8%) | 434 (72.0%) | 537 (75.0%) | 163 (63.2%) | 316 (72.1%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | |||||||
| Â Â Â onlys saba or non users | 699 (90.9%) | 204 (64.4%) | 359 (59.5%) | 632 (88.3%) | 176 (68.2%) | 282 (64.4%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 42 (5.5%) | 48 (15.1%) | 140 (23.2%) | 44 (6.1%) | 50 (19.4%) | 85 (19.4%) | 409 (13.2%) | |
| Â Â Â step3 | 15 (2.0%) | 17 (5.4%) | 41 (6.8%) | 15 (2.1%) | 11 (4.3%) | 19 (4.3%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 13 (1.7%) | 48 (15.1%) | 63 (10.4%) | 25 (3.5%) | 21 (8.1%) | 52 (11.9%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | |||||||
| Â Â Â No | 747 (97.1%) | 281 (88.6%) | 580 (96.2%) | 668 (93.3%) | 251 (97.3%) | 411 (93.8%) | 2938 (94.7%) | |
| Â Â Â Yes | 22 (2.9%) | 36 (11.4%) | 23 (3.8%) | 48 (6.7%) | 7 (2.7%) | 27 (6.2%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | |||||||
| Â Â Â No | 710 (92.3%) | 226 (71.3%) | 524 (86.9%) | 607 (84.8%) | 224 (86.8%) | 349 (79.7%) | 2640 (85.1%) | |
| Â Â Â Yes | 59 (7.7%) | 91 (28.7%) | 79 (13.1%) | 109 (15.2%) | 34 (13.2%) | 89 (20.3%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | |||||||
| Â Â Â No | 736 (95.7%) | 245 (77.3%) | 499 (82.8%) | 661 (92.3%) | 221 (85.7%) | 346 (79.0%) | 2708 (87.3%) | |
| Â Â Â Yes | 33 (4.3%) | 72 (22.7%) | 104 (17.2%) | 55 (7.7%) | 37 (14.3%) | 92 (21.0%) | 393 (12.7%) | |
| gina_control | < 0.001 | |||||||
| Â Â Â controlled | 460 (59.8%) | 96 (30.3%) | 231 (38.3%) | 341 (47.6%) | 79 (30.6%) | 137 (31.3%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 262 (34.1%) | 152 (47.9%) | 300 (49.8%) | 318 (44.4%) | 127 (49.2%) | 232 (53.0%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 47 (6.1%) | 69 (21.8%) | 72 (11.9%) | 57 (8.0%) | 52 (20.2%) | 69 (15.8%) | 366 (11.8%) | |
| education | < 0.001 | |||||||
| Â Â Â primary | 449 (58.4%) | 90 (28.4%) | 354 (58.7%) | 267 (37.3%) | 147 (57.0%) | 184 (42.0%) | 1491 (48.1%) | |
| Â Â Â secondary | 290 (37.7%) | 120 (37.9%) | 222 (36.8%) | 311 (43.4%) | 91 (35.3%) | 188 (42.9%) | 1222 (39.4%) | |
| Â Â Â tertiary | 30 (3.9%) | 107 (33.8%) | 27 (4.5%) | 138 (19.3%) | 20 (7.8%) | 66 (15.1%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | |||||||
| Â Â Â No | 255 (33.2%) | 150 (47.3%) | 359 (59.5%) | 221 (30.9%) | 132 (51.2%) | 267 (61.0%) | 1384 (44.6%) | |
| Â Â Â Yes | 514 (66.8%) | 167 (52.7%) | 244 (40.5%) | 495 (69.1%) | 126 (48.8%) | 171 (39.0%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | |||||||
| Â Â Â never smoker | 551 (71.7%) | 75 (23.7%) | 410 (68.0%) | 288 (40.2%) | 163 (63.2%) | 195 (44.5%) | 1682 (54.2%) | |
| Â Â Â former smokers | 184 (23.9%) | 167 (52.7%) | 161 (26.7%) | 348 (48.6%) | 84 (32.6%) | 204 (46.6%) | 1148 (37.0%) | |
| Â Â Â current smoker | 34 (4.4%) | 75 (23.7%) | 32 (5.3%) | 80 (11.2%) | 11 (4.3%) | 39 (8.9%) | 271 (8.7%) | |
| pack_years | < 0.001 | |||||||
| Â Â Â Mean (SD) | 3.751 (3.977) | 28.083 (18.827) | 6.713 (11.301) | 14.228 (10.874) | 9.122 (9.196) | 15.116 (14.254) | 11.286 (13.388) | |
| Â Â Â Range | 0.000 - 36.250 | 0.100 - 112.500 | 0.000 - 88.000 | 0.000 - 68.250 | 0.000 - 55.500 | 0.000 - 111.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | |||||||
| Â Â Â No | 394 (51.2%) | 63 (19.9%) | 280 (46.4%) | 205 (28.6%) | 87 (33.7%) | 155 (35.4%) | 1184 (38.2%) | |
| Â Â Â Yes | 375 (48.8%) | 254 (80.1%) | 323 (53.6%) | 511 (71.4%) | 171 (66.3%) | 283 (64.6%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | |||||||
| Â Â Â No | 623 (81.0%) | 126 (39.7%) | 460 (76.3%) | 292 (40.8%) | 145 (56.2%) | 215 (49.1%) | 1861 (60.0%) | |
| Â Â Â Yes | 146 (19.0%) | 191 (60.3%) | 143 (23.7%) | 424 (59.2%) | 113 (43.8%) | 223 (50.9%) | 1240 (40.0%) | |
| household_damage | < 0.001 | |||||||
| Â Â Â No | 654 (85.0%) | 288 (90.9%) | 513 (85.1%) | 654 (91.3%) | 223 (86.4%) | 400 (91.3%) | 2732 (88.1%) | |
| Â Â Â Yes | 115 (15.0%) | 29 (9.1%) | 90 (14.9%) | 62 (8.7%) | 35 (13.6%) | 38 (8.7%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 769 (100.0%) | 181 (57.1%) | 60 (10.0%) | 716 (100.0%) | 61 (23.6%) | 112 (25.6%) | 1899 (61.2%) | |
| Â Â Â Yes | 0 (0.0%) | 136 (42.9%) | 543 (90.0%) | 0 (0.0%) | 197 (76.4%) | 326 (74.4%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 769 (100.0%) | 177 (55.8%) | 83 (13.8%) | 716 (100.0%) | 70 (27.1%) | 112 (25.6%) | 1927 (62.1%) | |
| Â Â Â Yes | 0 (0.0%) | 140 (44.2%) | 520 (86.2%) | 0 (0.0%) | 188 (72.9%) | 326 (74.4%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 755 (98.2%) | 271 (85.5%) | 344 (57.0%) | 713 (99.6%) | 154 (59.7%) | 301 (68.7%) | 2538 (81.8%) | |
| Â Â Â Yes | 14 (1.8%) | 46 (14.5%) | 259 (43.0%) | 3 (0.4%) | 104 (40.3%) | 137 (31.3%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 766 (99.6%) | 279 (88.0%) | 492 (81.6%) | 714 (99.7%) | 224 (86.8%) | 341 (77.9%) | 2816 (90.8%) | |
| Â Â Â Yes | 3 (0.4%) | 38 (12.0%) | 111 (18.4%) | 2 (0.3%) | 34 (13.2%) | 97 (22.1%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 769 (100.0%) | 257 (81.1%) | 319 (52.9%) | 716 (100.0%) | 165 (64.0%) | 263 (60.0%) | 2489 (80.3%) | |
| Â Â Â Yes | 0 (0.0%) | 60 (18.9%) | 284 (47.1%) | 0 (0.0%) | 93 (36.0%) | 175 (40.0%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | |||||||
| Â Â Â No | 769 (100.0%) | 300 (94.6%) | 528 (87.6%) | 716 (100.0%) | 233 (90.3%) | 390 (89.0%) | 2936 (94.7%) | |
| Â Â Â Yes | 0 (0.0%) | 17 (5.4%) | 75 (12.4%) | 0 (0.0%) | 25 (9.7%) | 48 (11.0%) | 165 (5.3%) | |
| XCOPD | < 0.001 | |||||||
| Â Â Â No | 759 (98.7%) | 218 (68.8%) | 561 (93.0%) | 690 (96.4%) | 240 (93.0%) | 359 (82.0%) | 2827 (91.2%) | |
| Â Â Â Yes | 10 (1.3%) | 99 (31.2%) | 42 (7.0%) | 26 (3.6%) | 18 (7.0%) | 79 (18.0%) | 274 (8.8%) |
1.4.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## exertion_triggered_asthma 0.000000e+00 5
## infection_triggered_asthma 0.000000e+00 5
## Breathlessness 1.315901e-231 5
## weather_triggered_asthma 4.247154e-172 5
## allergen_triggered_asthma 2.791367e-144 5
## dyspenea 1.783449e-87 5
## Recurrent_wheeze 7.735567e-84 5
## smoking_exposure_at_work 2.365184e-83 5
## smoking_status 2.171838e-76 10
## familial_allergy 2.241856e-68 5
## XCOPD 3.437973e-68 5
## irritant_triggered_asthma 4.771885e-62 5
## education 2.766555e-61 10
## gina_steps 5.790382e-61 15
## Cough 6.563369e-56 5
## Chronic_productive_cough 3.712578e-47 5
## urbanization_level 7.554041e-42 5
## gina_control 1.152693e-37 10
## emotion_triggered_asthma 2.562846e-37 5
## smoking_exposure_at_home 1.952923e-30 5
## spt_any 3.606954e-30 5
## severe_asthma 4.682529e-27 5
## Emergency_last_year 2.739360e-18 5
## Drug_induced_dyspnea 5.262740e-18 5
## Gender 1.981940e-15 5
## nasal_plyposis 3.962674e-09 5
## Hosptalization_last_year 5.482587e-08 5
## household_damage 6.831432e-05 5
## Ever_rhinitis 3.611020e-03 5
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 40.494997 100.0000000 61.238310
## infection_triggered_asthma=No 39.906591 100.0000000 62.141245
## weather_triggered_asthma=No 30.895942 100.0000000 80.264431
## Breathlessness=No 38.046735 82.5747724 53.821348
## allergen_triggered_asthma=No 29.747833 98.1794538 81.844566
## smoking_exposure_at_work=No 33.476625 81.0143043 60.012899
## gina_steps=onlys saba or non users 29.719388 90.8972692 75.846501
## irritant_triggered_asthma=No 27.201705 99.6098830 90.809416
## Recurrent_wheeze=No 28.096677 96.7490247 85.391809
## Chronic_productive_cough=No 28.362235 95.7087126 83.682683
## dyspenea=No 28.148710 96.4889467 85.004837
## smoking_status=never smoker 32.758621 71.6514954 54.240568
## gina_control=controlled 34.226190 59.8179454 43.340858
## Cough=No 29.239510 86.9960988 73.782651
## XCOPD=No 26.848249 98.6996099 91.164141
## emotion_triggered_asthma=No 26.192098 100.0000000 94.679136
## severe_asthma=No 27.178730 95.7087126 87.326669
## smoking_exposure_at_home=No 33.277027 51.2353706 38.181232
## urbanization_level=Yes 29.935935 66.8400520 55.369236
## Emergency_last_year=No 26.893939 92.3276983 85.133828
## education=primary 30.114017 58.3875163 48.081264
## spt_any=Yes 27.723690 77.7633290 69.558207
## Drug_induced_dyspnea=No 25.569705 99.2197659 96.227024
## Hosptalization_last_year=No 25.425459 97.1391417 94.743631
## nasal_plyposis=No 26.947490 60.7282185 55.885198
## household_damage=Yes 31.165312 14.9544863 11.899387
## familial_allergy=Yes 27.136076 44.6033810 40.761045
## Ever_rhinitis=No 27.272727 31.5994798 28.732667
## Ever_rhinitis=Yes 23.800905 68.4005202 71.267333
## familial_allergy=No 23.189984 55.3966190 59.238955
## household_damage=No 23.938507 85.0455137 88.100613
## nasal_plyposis=Yes 22.076023 39.2717815 44.114802
## gina_steps=step3 12.711864 1.9505852 3.805224
## Hosptalization_last_year=Yes 13.496933 2.8608583 5.256369
## smoking_status=current smoker 12.546125 4.4213264 8.739116
## Drug_induced_dyspnea=Yes 5.128205 0.7802341 3.772976
## spt_any=No 18.114407 22.2366710 30.441793
## gina_control=uncontrolled 12.841530 6.1118336 11.802644
## Emergency_last_year=Yes 12.798265 7.6723017 14.866172
## gina_control=partially controlled 18.835370 34.0702211 44.856498
## urbanization_level=No 18.424855 33.1599480 44.630764
## gina_steps=step4 or 5 5.855856 1.6905072 7.158981
## gina_steps=step 1 or 2 10.268949 5.4616385 13.189294
## smoking_exposure_at_home=Yes 19.561815 48.7646294 61.818768
## severe_asthma=Yes 8.396947 4.2912874 12.673331
## smoking_status=former smokers 16.027875 23.9271782 37.020316
## education=tertiary 7.731959 3.9011704 12.512093
## emotion_triggered_asthma=Yes 0.000000 0.0000000 5.320864
## XCOPD=Yes 3.649635 1.3003901 8.835859
## Cough=Yes 12.300123 13.0039012 26.217349
## dyspenea=Yes 5.806452 3.5110533 14.995163
## Chronic_productive_cough=Yes 6.521739 4.2912874 16.317317
## Recurrent_wheeze=Yes 5.518764 3.2509753 14.608191
## irritant_triggered_asthma=Yes 1.052632 0.3901170 9.190584
## smoking_exposure_at_work=Yes 11.774194 18.9856957 39.987101
## allergen_triggered_asthma=Yes 2.486679 1.8205462 18.155434
## Breathlessness=Yes 9.357542 17.4252276 46.178652
## weather_triggered_asthma=Yes 0.000000 0.0000000 19.735569
## infection_triggered_asthma=Yes 0.000000 0.0000000 37.858755
## exertion_triggered_asthma=Yes 0.000000 0.0000000 38.761690
## p.value v.test
## exertion_triggered_asthma=No 2.438298e-198 30.046328
## infection_triggered_asthma=No 4.337466e-192 29.564017
## weather_triggered_asthma=No 1.026574e-86 19.737539
## Breathlessness=No 1.636908e-81 19.122615
## allergen_triggered_asthma=No 1.537994e-56 15.844352
## smoking_exposure_at_work=No 8.551560e-46 14.204825
## gina_steps=onlys saba or non users 1.375769e-33 12.078274
## irritant_triggered_asthma=No 1.092237e-32 11.906693
## Recurrent_wheeze=No 4.888177e-31 11.585376
## Chronic_productive_cough=No 5.694981e-31 11.572279
## dyspenea=No 7.798315e-31 11.545284
## smoking_status=never smoker 8.354126e-30 11.339583
## gina_control=controlled 3.141234e-26 10.595065
## Cough=No 5.689464e-24 10.097109
## XCOPD=No 5.652809e-23 9.869353
## emotion_triggered_asthma=No 8.424797e-22 9.594594
## severe_asthma=No 1.033506e-18 8.831425
## smoking_exposure_at_home=No 1.816991e-17 8.504934
## urbanization_level=Yes 1.002414e-13 7.440584
## Emergency_last_year=No 8.008693e-12 6.838392
## education=primary 4.193492e-11 6.597075
## spt_any=Yes 6.208770e-09 5.811035
## Drug_induced_dyspnea=No 1.131916e-08 5.709676
## Hosptalization_last_year=No 3.011111e-04 3.614342
## nasal_plyposis=No 1.775633e-03 3.125400
## household_damage=Yes 3.140848e-03 2.953606
## familial_allergy=Yes 1.269296e-02 2.492270
## Ever_rhinitis=No 4.397435e-02 2.014335
## Ever_rhinitis=Yes 4.397435e-02 -2.014335
## familial_allergy=No 1.269296e-02 -2.492270
## household_damage=No 3.140848e-03 -2.953606
## nasal_plyposis=Yes 1.775633e-03 -3.125400
## gina_steps=step3 1.062076e-03 -3.273545
## Hosptalization_last_year=Yes 3.011111e-04 -3.614342
## smoking_status=current smoker 2.080463e-07 -5.192001
## Drug_induced_dyspnea=Yes 1.131916e-08 -5.709676
## spt_any=No 6.208770e-09 -5.811035
## gina_control=uncontrolled 2.337914e-09 -5.972398
## Emergency_last_year=Yes 8.008693e-12 -6.838392
## gina_control=partially controlled 2.828943e-12 -6.985970
## urbanization_level=No 1.002414e-13 -7.440584
## gina_steps=step4 or 5 1.833419e-14 -7.661802
## gina_steps=step 1 or 2 3.403770e-15 -7.875134
## smoking_exposure_at_home=Yes 1.816991e-17 -8.504934
## severe_asthma=Yes 1.033506e-18 -8.831425
## smoking_status=former smokers 7.812822e-19 -8.862659
## education=tertiary 4.278310e-20 -9.180817
## emotion_triggered_asthma=Yes 8.424797e-22 -9.594594
## XCOPD=Yes 5.652809e-23 -9.869353
## Cough=Yes 5.689464e-24 -10.097109
## dyspenea=Yes 7.798315e-31 -11.545284
## Chronic_productive_cough=Yes 5.694981e-31 -11.572279
## Recurrent_wheeze=Yes 4.888177e-31 -11.585376
## irritant_triggered_asthma=Yes 1.092237e-32 -11.906693
## smoking_exposure_at_work=Yes 8.551560e-46 -14.204825
## allergen_triggered_asthma=Yes 1.537994e-56 -15.844352
## Breathlessness=Yes 1.636908e-81 -19.122615
## weather_triggered_asthma=Yes 1.026574e-86 -19.737539
## infection_triggered_asthma=Yes 4.337466e-192 -29.564017
## exertion_triggered_asthma=Yes 2.438298e-198 -30.046328
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=Yes 30.322581 44.479495 14.995163 1.333168e-41
## XCOPD=Yes 36.131387 31.230284 8.835859 8.480616e-35
## Recurrent_wheeze=Yes 28.035320 40.063091 14.608191 1.374801e-32
## education=tertiary 27.577320 33.753943 12.512093 5.634494e-26
## Breathlessness=Yes 16.131285 72.870662 46.178652 3.504389e-24
## Cough=Yes 19.065191 48.895899 26.217349 5.355394e-20
## smoking_status=current smoker 27.675277 23.659306 8.739116 9.804489e-18
## Chronic_productive_cough=Yes 20.553360 32.807571 16.317317 1.494267e-14
## smoking_exposure_at_work=Yes 15.403226 60.252366 39.987101 1.721230e-14
## smoking_exposure_at_home=Yes 13.249870 80.126183 61.818768 1.747210e-13
## familial_allergy=No 13.228089 76.656151 59.238955 6.996973e-12
## Emergency_last_year=Yes 19.739696 28.706625 14.866172 1.831257e-11
## smoking_status=former smokers 14.547038 52.681388 37.020316 2.193661e-09
## gina_control=uncontrolled 18.852459 21.766562 11.802644 9.193565e-08
## severe_asthma=Yes 18.320611 22.712934 12.673331 1.538299e-07
## gina_steps=step4 or 5 21.621622 15.141956 7.158981 1.897180e-07
## spt_any=No 14.618644 43.533123 30.441793 2.050185e-07
## Hosptalization_last_year=Yes 22.085890 11.356467 5.256369 4.891378e-06
## Drug_induced_dyspnea=Yes 20.512821 7.570978 3.772976 7.527820e-04
## infection_triggered_asthma=Yes 11.925043 44.164038 37.858755 1.544327e-02
## nasal_plyposis=Yes 11.549708 49.842271 44.114802 3.088099e-02
## Gender=Yes 11.148840 62.145110 56.981619 4.955780e-02
## Gender=No 8.995502 37.854890 43.018381 4.955780e-02
## nasal_plyposis=No 9.174841 50.157729 55.885198 3.088099e-02
## infection_triggered_asthma=No 9.185262 55.835962 62.141245 1.544327e-02
## Drug_induced_dyspnea=No 9.819035 92.429022 96.227024 7.527820e-04
## Hosptalization_last_year=No 9.564329 88.643533 94.743631 4.891378e-06
## gina_steps=onlys saba or non users 8.673469 64.353312 75.846501 1.224595e-06
## gina_control=controlled 7.142857 30.283912 43.340858 5.158326e-07
## spt_any=Yes 8.298563 56.466877 69.558207 2.050185e-07
## severe_asthma=No 9.047267 77.287066 87.326669 1.538299e-07
## Emergency_last_year=No 8.560606 71.293375 85.133828 1.831257e-11
## familial_allergy=Yes 5.854430 23.343849 40.761045 6.996973e-12
## smoking_exposure_at_home=No 5.320946 19.873817 38.181232 1.747210e-13
## education=primary 6.036217 28.391167 48.081264 5.598681e-14
## smoking_exposure_at_work=No 6.770553 39.747634 60.012899 1.721230e-14
## Chronic_productive_cough=No 8.208092 67.192429 83.682683 1.494267e-14
## Cough=No 7.080420 51.104101 73.782651 5.355394e-20
## Breathlessness=No 5.152786 27.129338 53.821348 3.504389e-24
## smoking_status=never smoker 4.458977 23.659306 54.240568 1.633376e-31
## Recurrent_wheeze=No 7.175227 59.936909 85.391809 1.374801e-32
## XCOPD=No 7.711355 68.769716 91.164141 8.480616e-35
## dyspenea=No 6.676783 55.520505 85.004837 1.333168e-41
## v.test
## dyspenea=Yes 13.511749
## XCOPD=Yes 12.305314
## Recurrent_wheeze=Yes 11.887488
## education=tertiary 10.540257
## Breathlessness=Yes 10.144536
## Cough=Yes 9.156609
## smoking_status=current smoker 8.576217
## Chronic_productive_cough=Yes 7.688022
## smoking_exposure_at_work=Yes 7.669906
## smoking_exposure_at_home=Yes 7.366839
## familial_allergy=No 6.857717
## Emergency_last_year=Yes 6.718881
## smoking_status=former smokers 5.982776
## gina_control=uncontrolled 5.341982
## severe_asthma=Yes 5.247915
## gina_steps=step4 or 5 5.209140
## spt_any=No 5.194729
## Hosptalization_last_year=Yes 4.569393
## Drug_induced_dyspnea=Yes 3.369597
## infection_triggered_asthma=Yes 2.421814
## nasal_plyposis=Yes 2.158603
## Gender=Yes 1.963761
## Gender=No -1.963761
## nasal_plyposis=No -2.158603
## infection_triggered_asthma=No -2.421814
## Drug_induced_dyspnea=No -3.369597
## Hosptalization_last_year=No -4.569393
## gina_steps=onlys saba or non users -4.851616
## gina_control=controlled -5.020328
## spt_any=Yes -5.194729
## severe_asthma=No -5.247915
## Emergency_last_year=No -6.718881
## familial_allergy=Yes -6.857717
## smoking_exposure_at_home=No -7.366839
## education=primary -7.517142
## smoking_exposure_at_work=No -7.669906
## Chronic_productive_cough=No -7.688022
## Cough=No -9.156609
## Breathlessness=No -10.144536
## smoking_status=never smoker -11.678931
## Recurrent_wheeze=No -11.887488
## XCOPD=No -12.305314
## dyspenea=No -13.511749
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 45.174709 90.049751 38.761690 3.136585e-190
## infection_triggered_asthma=Yes 44.293015 86.235489 37.858755 1.211267e-166
## weather_triggered_asthma=Yes 46.405229 47.097844 19.735569 5.898885e-68
## allergen_triggered_asthma=Yes 46.003552 42.951907 18.155434 2.592617e-59
## Breathlessness=Yes 30.377095 72.139303 46.178652 9.100042e-47
## familial_allergy=Yes 31.487342 66.003317 40.761045 2.965570e-44
## smoking_exposure_at_work=No 24.717894 76.285240 60.012899 1.114023e-20
## urbanization_level=No 25.939306 59.535655 44.630764 2.873436e-16
## irritant_triggered_asthma=Yes 38.947368 18.407960 9.190584 8.288500e-16
## emotion_triggered_asthma=Yes 45.454545 12.437811 5.320864 5.543395e-15
## smoking_status=never smoker 24.375743 67.993367 54.240568 2.323866e-14
## gina_steps=step 1 or 2 34.229829 23.217247 13.189294 2.482831e-14
## Gender=Yes 23.089983 67.661692 56.981619 2.513163e-09
## education=primary 23.742455 58.706468 48.081264 5.949612e-09
## smoking_exposure_at_home=No 23.648649 46.434494 38.181232 4.094094e-06
## nasal_plyposis=No 22.042701 63.349917 55.885198 3.583021e-05
## gina_steps=step3 34.745763 6.799337 3.805224 6.902157e-05
## Cough=Yes 24.231242 32.669983 26.217349 8.022982e-05
## severe_asthma=Yes 26.463104 17.247098 12.673331 2.738761e-04
## gina_steps=step4 or 5 28.378378 10.447761 7.158981 8.399671e-04
## gina_control=partially controlled 21.567218 49.751244 44.856498 7.242343e-03
## household_damage=Yes 24.390244 14.925373 11.899387 1.248138e-02
## household_damage=No 18.777452 85.074627 88.100613 1.248138e-02
## gina_control=controlled 17.187500 38.308458 43.340858 5.340899e-03
## smoking_status=current smoker 11.808118 5.306799 8.739116 4.978713e-04
## severe_asthma=No 18.426883 82.752902 87.326669 2.738761e-04
## Cough=No 17.744755 67.330017 73.782651 8.022982e-05
## nasal_plyposis=Yes 16.154971 36.650083 44.114802 3.583021e-05
## smoking_exposure_at_home=Yes 16.849244 53.565506 61.818768 4.094094e-06
## smoking_status=former smokers 14.024390 26.699834 37.020316 2.705003e-09
## Gender=No 14.617691 32.338308 43.018381 2.513163e-09
## education=tertiary 6.958763 4.477612 12.512093 2.757149e-13
## emotion_triggered_asthma=No 17.983651 87.562189 94.679136 5.543395e-15
## irritant_triggered_asthma=No 17.471591 81.592040 90.809416 8.288500e-16
## urbanization_level=Yes 14.210833 40.464345 55.369236 2.873436e-16
## smoking_exposure_at_work=Yes 11.532258 23.714760 39.987101 1.114023e-20
## gina_steps=onlys saba or non users 15.263605 59.535655 75.846501 1.683461e-23
## familial_allergy=No 11.159499 33.996683 59.238955 2.965570e-44
## Breathlessness=No 10.065908 27.860697 53.821348 9.100042e-47
## allergen_triggered_asthma=No 13.553980 57.048093 81.844566 2.592617e-59
## weather_triggered_asthma=No 12.816392 52.902156 80.264431 5.898885e-68
## infection_triggered_asthma=No 4.307213 13.764511 62.141245 1.211267e-166
## exertion_triggered_asthma=No 3.159558 9.950249 61.238310 3.136585e-190
## v.test
## exertion_triggered_asthma=Yes 29.419023
## infection_triggered_asthma=Yes 27.513476
## weather_triggered_asthma=Yes 17.419207
## allergen_triggered_asthma=Yes 16.240861
## Breathlessness=Yes 14.360928
## familial_allergy=Yes 13.954213
## smoking_exposure_at_work=No 9.324601
## urbanization_level=No 8.178523
## irritant_triggered_asthma=Yes 8.049866
## emotion_triggered_asthma=Yes 7.813925
## smoking_status=never smoker 7.631306
## gina_steps=step 1 or 2 7.622773
## Gender=Yes 5.960598
## education=primary 5.818168
## smoking_exposure_at_home=No 4.606548
## nasal_plyposis=No 4.132844
## gina_steps=step3 3.979634
## Cough=Yes 3.943713
## severe_asthma=Yes 3.638833
## gina_steps=step4 or 5 3.339277
## gina_control=partially controlled 2.685491
## household_damage=Yes 2.498234
## household_damage=No -2.498234
## gina_control=controlled -2.785720
## smoking_status=current smoker -3.481899
## severe_asthma=No -3.638833
## Cough=No -3.943713
## nasal_plyposis=Yes -4.132844
## smoking_exposure_at_home=Yes -4.606548
## smoking_status=former smokers -5.948567
## Gender=No -5.960598
## education=tertiary -7.305755
## emotion_triggered_asthma=No -7.813925
## irritant_triggered_asthma=No -8.049866
## urbanization_level=Yes -8.178523
## smoking_exposure_at_work=Yes -9.324601
## gina_steps=onlys saba or non users -9.990139
## familial_allergy=No -13.954213
## Breathlessness=No -14.360928
## allergen_triggered_asthma=No -16.240861
## weather_triggered_asthma=No -17.419207
## infection_triggered_asthma=No -27.513476
## exertion_triggered_asthma=No -29.419023
##
## $`3`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 37.7040548 100.0000000 61.238310
## infection_triggered_asthma=No 37.1562013 100.0000000 62.141245
## Breathlessness=No 36.8484122 85.8938547 53.821348
## weather_triggered_asthma=No 28.7665729 100.0000000 80.264431
## allergen_triggered_asthma=No 28.0929866 99.5810056 81.844566
## familial_allergy=No 30.5933587 78.4916201 59.238955
## smoking_exposure_at_work=Yes 34.1935484 59.2178771 39.987101
## irritant_triggered_asthma=No 25.3551136 99.7206704 90.809416
## Recurrent_wheeze=No 26.1706949 96.7877095 85.391809
## gina_steps=onlys saba or non users 26.8707483 88.2681564 75.846501
## emotion_triggered_asthma=No 24.3869210 100.0000000 94.679136
## urbanization_level=Yes 28.8293535 69.1340782 55.369236
## dyspenea=No 25.5311077 93.9944134 85.004837
## Cough=No 26.3986014 84.3575419 73.782651
## smoking_status=former smokers 30.3135889 48.6033520 37.020316
## Gender=No 28.7106447 53.4916201 43.018381
## smoking_exposure_at_home=Yes 26.6562337 71.3687151 61.818768
## XCOPD=No 24.4074991 96.3687151 91.164141
## education=tertiary 35.5670103 19.2737430 12.512093
## spt_any=Yes 25.5910987 77.0949721 69.558207
## Drug_induced_dyspnea=No 23.7600536 99.0223464 96.227024
## severe_asthma=No 24.4091581 92.3184358 87.326669
## Chronic_productive_cough=No 24.6242775 89.2458101 83.682683
## nasal_plyposis=Yes 26.7543860 51.1173184 44.114802
## household_damage=No 23.9385066 91.3407821 88.100613
## gina_control=controlled 25.3720238 47.6256983 43.340858
## smoking_status=current smoker 29.5202952 11.1731844 8.739116
## Ever_rhinitis=Yes 24.2986425 75.0000000 71.267333
## education=secondary 25.4500818 43.4357542 39.406643
## Ever_rhinitis=No 20.0897868 25.0000000 28.732667
## gina_steps=step3 12.7118644 2.0949721 3.805224
## household_damage=Yes 16.8021680 8.6592179 11.899387
## gina_control=uncontrolled 15.5737705 7.9608939 11.802644
## nasal_plyposis=No 20.1961916 48.8826816 55.885198
## gina_steps=step4 or 5 11.2612613 3.4916201 7.158981
## Chronic_productive_cough=Yes 15.2173913 10.7541899 16.317317
## severe_asthma=Yes 13.9949109 7.6815642 12.673331
## Drug_induced_dyspnea=Yes 5.9829060 0.9776536 3.772976
## spt_any=No 17.3728814 22.9050279 30.441793
## XCOPD=Yes 9.4890511 3.6312849 8.835859
## smoking_exposure_at_home=No 17.3141892 28.6312849 38.181232
## Gender=Yes 18.8455008 46.5083799 56.981619
## education=primary 17.9074447 37.2905028 48.081264
## gina_steps=step 1 or 2 10.7579462 6.1452514 13.189294
## Cough=Yes 13.7761378 15.6424581 26.217349
## dyspenea=Yes 9.2473118 6.0055866 14.995163
## urbanization_level=No 15.9682081 30.8659218 44.630764
## smoking_status=never smoker 17.1224732 40.2234637 54.240568
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## Recurrent_wheeze=Yes 5.0772627 3.2122905 14.608191
## irritant_triggered_asthma=Yes 0.7017544 0.2793296 9.190584
## smoking_exposure_at_work=No 15.6904890 40.7821229 60.012899
## familial_allergy=Yes 12.1835443 21.5083799 40.761045
## allergen_triggered_asthma=Yes 0.5328597 0.4189944 18.155434
## weather_triggered_asthma=Yes 0.0000000 0.0000000 19.735569
## Breathlessness=Yes 7.0530726 14.1061453 46.178652
## infection_triggered_asthma=Yes 0.0000000 0.0000000 37.858755
## exertion_triggered_asthma=Yes 0.0000000 0.0000000 38.761690
## p.value v.test
## exertion_triggered_asthma=No 6.116849e-182 28.763634
## infection_triggered_asthma=No 3.063222e-176 28.304256
## Breathlessness=No 5.297839e-94 20.568122
## weather_triggered_asthma=No 8.410963e-80 18.916062
## allergen_triggered_asthma=No 2.094540e-66 17.213741
## familial_allergy=No 7.659329e-35 12.313535
## smoking_exposure_at_work=Yes 1.700874e-32 11.869695
## irritant_triggered_asthma=No 2.310110e-31 11.649425
## Recurrent_wheeze=No 8.410679e-29 11.135674
## gina_steps=onlys saba or non users 8.313652e-21 9.355587
## emotion_triggered_asthma=No 3.932555e-20 9.189887
## urbanization_level=Yes 1.268301e-17 8.546543
## dyspenea=No 9.276122e-17 8.313703
## Cough=No 2.612096e-14 7.616221
## smoking_status=former smokers 4.637228e-13 7.235528
## Gender=No 1.330195e-10 6.423679
## smoking_exposure_at_home=Yes 1.227670e-09 6.076587
## XCOPD=No 1.321181e-09 6.064800
## education=tertiary 2.356928e-09 5.971077
## spt_any=Yes 3.668195e-07 5.085417
## Drug_induced_dyspnea=No 5.132811e-07 5.021281
## severe_asthma=No 1.717582e-06 4.784096
## Chronic_productive_cough=No 1.966228e-06 4.756865
## nasal_plyposis=Yes 1.796938e-05 4.288735
## household_damage=No 1.726307e-03 3.133677
## gina_control=controlled 8.516696e-03 2.630869
## smoking_status=current smoker 1.029353e-02 2.565810
## Ever_rhinitis=Yes 1.124696e-02 2.534931
## education=secondary 1.222106e-02 2.505696
## Ever_rhinitis=No 1.124696e-02 -2.534931
## gina_steps=step3 4.207151e-03 -2.862197
## household_damage=Yes 1.726307e-03 -3.133677
## gina_control=uncontrolled 1.715297e-04 -3.757631
## nasal_plyposis=No 1.796938e-05 -4.288735
## gina_steps=step4 or 5 3.620822e-06 -4.632039
## Chronic_productive_cough=Yes 1.966228e-06 -4.756865
## severe_asthma=Yes 1.717582e-06 -4.784096
## Drug_induced_dyspnea=Yes 5.132811e-07 -5.021281
## spt_any=No 3.668195e-07 -5.085417
## XCOPD=Yes 1.321181e-09 -6.064800
## smoking_exposure_at_home=No 1.227670e-09 -6.076587
## Gender=Yes 1.330195e-10 -6.423679
## education=primary 3.674880e-11 -6.616627
## gina_steps=step 1 or 2 1.075961e-11 -6.795957
## Cough=Yes 2.612096e-14 -7.616221
## dyspenea=Yes 9.276122e-17 -8.313703
## urbanization_level=No 1.268301e-17 -8.546543
## smoking_status=never smoker 1.000785e-17 -8.573854
## emotion_triggered_asthma=Yes 3.932555e-20 -9.189887
## Recurrent_wheeze=Yes 8.410679e-29 -11.135674
## irritant_triggered_asthma=Yes 2.310110e-31 -11.649425
## smoking_exposure_at_work=No 1.700874e-32 -11.869695
## familial_allergy=Yes 7.659329e-35 -12.313535
## allergen_triggered_asthma=Yes 2.094540e-66 -17.213741
## weather_triggered_asthma=Yes 8.410963e-80 -18.916062
## Breathlessness=Yes 5.297839e-94 -20.568122
## infection_triggered_asthma=Yes 3.063222e-176 -28.304256
## exertion_triggered_asthma=Yes 6.116849e-182 -28.763634
##
## $`4`
## Cla/Mod Mod/Cla Global p.value
## Breathlessness=Yes 15.782123 87.596899 46.178652 1.050427e-47
## exertion_triggered_asthma=Yes 16.389351 76.356589 38.761690 1.213196e-37
## infection_triggered_asthma=Yes 16.013629 72.868217 37.858755 9.924401e-33
## allergen_triggered_asthma=Yes 18.472469 40.310078 18.155434 2.227857e-18
## weather_triggered_asthma=Yes 15.196078 36.046512 19.735569 1.506594e-10
## Recurrent_wheeze=Yes 16.556291 29.069767 14.608191 3.668794e-10
## gina_control=uncontrolled 14.207650 20.155039 11.802644 5.443568e-05
## Gender=No 10.419790 53.875969 43.018381 2.601911e-04
## familial_allergy=Yes 10.363924 50.775194 40.761045 7.099288e-04
## smoking_status=never smoker 9.690844 63.178295 54.240568 2.507966e-03
## emotion_triggered_asthma=Yes 15.151515 9.689922 5.320864 2.822707e-03
## education=primary 9.859155 56.976744 48.081264 2.869945e-03
## Ever_rhinitis=No 10.662177 36.821705 28.732667 3.344065e-03
## gina_steps=step 1 or 2 12.224939 19.379845 13.189294 3.477925e-03
## nasal_plyposis=Yes 9.941520 52.713178 44.114802 3.865166e-03
## spt_any=Yes 9.040334 75.581395 69.558207 2.618199e-02
## irritant_triggered_asthma=Yes 11.929825 13.178295 9.190584 2.698563e-02
## urbanization_level=No 9.537572 51.162791 44.630764 2.820114e-02
## Hosptalization_last_year=No 8.543227 97.286822 94.743631 4.419890e-02
## dyspenea=No 8.725341 89.147287 85.004837 4.605953e-02
## dyspenea=Yes 6.021505 10.852713 14.995163 4.605953e-02
## Hosptalization_last_year=Yes 4.294479 2.713178 5.256369 4.419890e-02
## urbanization_level=Yes 7.338381 48.837209 55.369236 2.820114e-02
## irritant_triggered_asthma=No 7.954545 86.821705 90.809416 2.698563e-02
## spt_any=No 6.673729 24.418605 30.441793 2.618199e-02
## education=tertiary 5.154639 7.751938 12.512093 1.170617e-02
## smoking_status=current smoker 4.059041 4.263566 8.739116 4.399601e-03
## nasal_plyposis=No 7.039815 47.286822 55.885198 3.865166e-03
## gina_steps=onlys saba or non users 7.482993 68.217054 75.846501 3.626517e-03
## Ever_rhinitis=Yes 7.375566 63.178295 71.267333 3.344065e-03
## emotion_triggered_asthma=No 7.935967 90.310078 94.679136 2.822707e-03
## familial_allergy=No 6.913446 49.224806 59.238955 7.099288e-04
## Gender=Yes 6.734578 46.124031 56.981619 2.601911e-04
## gina_control=controlled 5.877976 30.620155 43.340858 1.283140e-05
## Recurrent_wheeze=No 6.910876 70.930233 85.391809 3.668794e-10
## weather_triggered_asthma=No 6.629168 63.953488 80.264431 1.506594e-10
## allergen_triggered_asthma=No 6.067770 59.689922 81.844566 2.227857e-18
## infection_triggered_asthma=No 3.632590 27.131783 62.141245 9.924401e-33
## exertion_triggered_asthma=No 3.212217 23.643411 61.238310 1.213196e-37
## Breathlessness=No 1.917316 12.403101 53.821348 1.050427e-47
## v.test
## Breathlessness=Yes 14.509789
## exertion_triggered_asthma=Yes 12.823364
## infection_triggered_asthma=Yes 11.914682
## allergen_triggered_asthma=Yes 8.745116
## weather_triggered_asthma=Yes 6.404706
## Recurrent_wheeze=Yes 6.267505
## gina_control=uncontrolled 4.035718
## Gender=No 3.652015
## familial_allergy=Yes 3.385716
## smoking_status=never smoker 3.022379
## emotion_triggered_asthma=Yes 2.986413
## education=primary 2.981335
## Ever_rhinitis=No 2.934202
## gina_steps=step 1 or 2 2.921999
## nasal_plyposis=Yes 2.888961
## spt_any=Yes 2.223502
## irritant_triggered_asthma=Yes 2.211726
## urbanization_level=No 2.194477
## Hosptalization_last_year=No 2.012200
## dyspenea=No 1.994847
## dyspenea=Yes -1.994847
## Hosptalization_last_year=Yes -2.012200
## urbanization_level=Yes -2.194477
## irritant_triggered_asthma=No -2.211726
## spt_any=No -2.223502
## education=tertiary -2.520880
## smoking_status=current smoker -2.847992
## nasal_plyposis=No -2.888961
## gina_steps=onlys saba or non users -2.908944
## Ever_rhinitis=Yes -2.934202
## emotion_triggered_asthma=No -2.986413
## familial_allergy=No -3.385716
## Gender=Yes -3.652015
## gina_control=controlled -4.362961
## Recurrent_wheeze=No -6.267505
## weather_triggered_asthma=No -6.404706
## allergen_triggered_asthma=No -8.745116
## infection_triggered_asthma=No -11.914682
## exertion_triggered_asthma=No -12.823364
## Breathlessness=No -14.509789
##
## $`5`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 27.768313 74.429224 37.858755 1.613554e-63
## exertion_triggered_asthma=Yes 27.121464 74.429224 38.761690 2.400428e-60
## Breathlessness=Yes 21.298883 69.634703 46.178652 1.295850e-26
## weather_triggered_asthma=Yes 28.594771 39.954338 19.735569 1.712877e-26
## irritant_triggered_asthma=Yes 34.035088 22.146119 9.190584 2.148816e-19
## spt_any=No 22.881356 49.315068 30.441793 3.600131e-19
## dyspenea=Yes 27.526882 29.223744 14.995163 9.296215e-17
## Cough=Yes 22.878229 42.465753 26.217349 1.244716e-15
## Chronic_productive_cough=Yes 26.284585 30.365297 16.317317 1.339483e-15
## urbanization_level=No 19.291908 60.958904 44.630764 1.435331e-13
## allergen_triggered_asthma=Yes 24.333925 31.278539 18.155434 4.528579e-13
## XCOPD=Yes 28.832117 18.036530 8.835859 2.823776e-11
## Recurrent_wheeze=Yes 23.841060 24.657534 14.608191 1.575431e-09
## Drug_induced_dyspnea=Yes 35.897436 9.589041 3.772976 1.791912e-09
## severe_asthma=Yes 23.409669 21.004566 12.673331 1.072999e-07
## emotion_triggered_asthma=Yes 29.090909 10.958904 5.320864 2.983542e-07
## smoking_exposure_at_work=Yes 17.983871 50.913242 39.987101 6.115324e-07
## smoking_status=former smokers 17.770035 46.575342 37.020316 1.015279e-05
## gina_steps=step 1 or 2 20.782396 19.406393 13.189294 7.439410e-05
## gina_steps=step4 or 5 23.423423 11.872146 7.158981 1.134022e-04
## gina_control=partially controlled 16.678648 52.968037 44.856498 2.434272e-04
## Emergency_last_year=Yes 19.305857 20.319635 14.866172 8.354263e-04
## gina_control=uncontrolled 18.852459 15.753425 11.802644 7.484030e-03
## household_damage=No 14.641288 91.324201 88.100613 2.096521e-02
## household_damage=Yes 10.298103 8.675799 11.899387 2.096521e-02
## education=primary 12.340711 42.009132 48.081264 6.020154e-03
## Emergency_last_year=No 13.219697 79.680365 85.133828 8.354263e-04
## smoking_status=never smoker 11.593341 44.520548 54.240568 1.120243e-05
## smoking_exposure_at_work=No 11.552929 49.086758 60.012899 6.115324e-07
## emotion_triggered_asthma=No 13.283379 89.041096 94.679136 2.983542e-07
## severe_asthma=No 12.776957 78.995434 87.326669 1.072999e-07
## gina_control=controlled 10.193452 31.278539 43.340858 2.633633e-08
## gina_steps=onlys saba or non users 11.989796 64.383562 75.846501 5.539806e-09
## Drug_induced_dyspnea=No 13.270777 90.410959 96.227024 1.791912e-09
## Recurrent_wheeze=No 12.462236 75.342466 85.391809 1.575431e-09
## XCOPD=No 12.698974 81.963470 91.164141 2.823776e-11
## allergen_triggered_asthma=No 11.859732 68.721461 81.844566 4.528579e-13
## urbanization_level=Yes 9.959231 39.041096 55.369236 1.435331e-13
## Chronic_productive_cough=No 11.753372 69.634703 83.682683 1.339483e-15
## Cough=No 11.013986 57.534247 73.782651 1.244716e-15
## dyspenea=No 11.760243 70.776256 85.004837 9.296215e-17
## spt_any=Yes 10.292072 50.684932 69.558207 3.600131e-19
## irritant_triggered_asthma=No 12.109375 77.853881 90.809416 2.148816e-19
## weather_triggered_asthma=No 10.566493 60.045662 80.264431 1.712877e-26
## Breathlessness=No 7.968844 30.365297 53.821348 1.295850e-26
## exertion_triggered_asthma=No 5.897841 25.570776 61.238310 2.400428e-60
## infection_triggered_asthma=No 5.812143 25.570776 62.141245 1.613554e-63
## v.test
## infection_triggered_asthma=Yes 16.824523
## exertion_triggered_asthma=Yes 16.386186
## Breathlessness=Yes 10.677595
## weather_triggered_asthma=Yes 10.651657
## irritant_triggered_asthma=Yes 9.005400
## spt_any=No 8.948602
## dyspenea=Yes 8.313446
## Cough=Yes 7.999948
## Chronic_productive_cough=Yes 7.990908
## urbanization_level=No 7.393018
## allergen_triggered_asthma=Yes 7.238744
## XCOPD=Yes 6.655480
## Recurrent_wheeze=Yes 6.036448
## Drug_induced_dyspnea=Yes 6.015628
## severe_asthma=Yes 5.313906
## emotion_triggered_asthma=Yes 5.124484
## smoking_exposure_at_work=Yes 4.987539
## smoking_status=former smokers 4.413894
## gina_steps=step 1 or 2 3.961777
## gina_steps=step4 or 5 3.859967
## gina_control=partially controlled 3.669078
## Emergency_last_year=Yes 3.340783
## gina_control=uncontrolled 2.674502
## household_damage=No 2.308610
## household_damage=Yes -2.308610
## education=primary -2.746682
## Emergency_last_year=No -3.340783
## smoking_status=never smoker -4.392559
## smoking_exposure_at_work=No -4.987539
## emotion_triggered_asthma=No -5.124484
## severe_asthma=No -5.313906
## gina_control=controlled -5.564196
## gina_steps=onlys saba or non users -5.830088
## Drug_induced_dyspnea=No -6.015628
## Recurrent_wheeze=No -6.036448
## XCOPD=No -6.655480
## allergen_triggered_asthma=No -7.238744
## urbanization_level=Yes -7.393018
## Chronic_productive_cough=No -7.990908
## Cough=No -7.999948
## dyspenea=No -8.313446
## spt_any=Yes -8.948602
## irritant_triggered_asthma=No -9.005400
## weather_triggered_asthma=No -10.651657
## Breathlessness=No -10.677595
## exertion_triggered_asthma=No -16.386186
## infection_triggered_asthma=No -16.824523
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.479239925 0.000000e+00
## onset_age_asthma 0.437962153 0.000000e+00
## FeNO 0.449199531 0.000000e+00
## pack_years 0.287135962 2.384454e-224
## Eosinophiles 0.212959499 5.138299e-158
## kco 0.199113630 2.441463e-146
## FEV1_FVC_ratio_post 0.176764343 6.427509e-128
## Reversibility 0.165021090 1.916978e-118
## tlco 0.158407565 3.616631e-113
## BMI 0.097051402 3.422019e-66
## Monocytes 0.080481222 4.312290e-54
## Neutrophiles 0.078375580 1.428296e-52
## Basophiles 0.064112972 2.218890e-42
## pd20 0.053186248 1.063908e-34
## Lymphocytes 0.006675664 9.067834e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 17.337412 8.308009e-01 7.832420e-01 5.582802e-02
## tlco 12.093427 1.074497e+02 9.981259e+01 1.374880e+01
## kco 11.389221 1.027260e+02 9.737797e+01 1.192846e+01
## Lymphocytes -2.608296 1.909493e+00 1.962441e+00 5.240101e-01
## pd20 -4.882120 1.925944e+03 2.320957e+03 2.787757e+03
## Basophiles -8.931965 1.539662e-02 2.780071e-02 3.419716e-02
## FeNO -9.144006 1.758843e+01 2.306080e+01 9.236737e+00
## Eosinophiles -9.343632 1.569051e-01 2.004192e-01 1.084675e-01
## Neutrophiles -9.697860 3.348349e+00 3.757449e+00 1.129812e+00
## Reversibility -10.084286 3.835753e+00 5.948107e+00 3.284065e+00
## Monocytes -10.277054 3.706502e-01 4.195937e-01 1.238128e-01
## BMI -12.383841 2.480887e+01 2.661552e+01 3.853377e+00
## pack_years -17.997089 3.750762e+00 1.128550e+01 3.974675e+00
## onset_age_asthma -18.736177 2.644993e+00 1.277169e+01 7.058375e+00
## Age -25.533561 3.800260e+01 5.047952e+01 1.078445e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 2.455450e-67
## tlco 2.019103e+01 1.144122e-33
## kco 1.501340e+01 4.731985e-30
## Lymphocytes 6.490450e-01 9.099415e-03
## pd20 2.586920e+03 1.049511e-06
## Basophiles 4.440150e-02 4.185080e-19
## FeNO 1.913459e+01 6.018065e-20
## Eosinophiles 1.488999e-01 9.308462e-21
## Neutrophiles 1.348758e+00 3.078874e-22
## Reversibility 6.697326e+00 6.483508e-24
## Monocytes 1.522671e-01 8.941877e-25
## BMI 4.664452e+00 3.196695e-35
## pack_years 1.338584e+01 2.053327e-72
## onset_age_asthma 1.728090e+01 2.510303e-78
## Age 1.562341e+01 8.360935e-144
##
## $`1`
## v.test Mean in category Overall mean sd in category
## pack_years 23.576424 2.808312e+01 1.128550e+01 1.879693e+01
## Age 17.180756 6.476656e+01 5.047952e+01 9.041915e+00
## onset_age_asthma 15.630216 2.714826e+01 1.277169e+01 2.123193e+01
## Neutrophiles 12.288396 4.639621e+00 3.757449e+00 1.621298e+00
## Monocytes 11.960691 5.165300e-01 4.195937e-01 1.954771e-01
## BMI 10.573312 2.924056e+01 2.661552e+01 5.279550e+00
## Basophiles 9.353236 4.990536e-02 2.780071e-02 5.258903e-02
## pd20 4.237466 2.904420e+03 2.320957e+03 2.150745e+03
## Lymphocytes 4.016592 2.101199e+00 1.962441e+00 7.089703e-01
## Reversibility 3.048378 7.034769e+00 5.948107e+00 8.027841e+00
## Eosinophiles 2.705492 2.218612e-01 2.004192e-01 1.318325e-01
## FeNO -4.892730 1.807776e+01 2.306080e+01 1.212638e+01
## tlco -12.971443 8.587233e+01 9.981259e+01 1.786710e+01
## kco -13.316756 8.673650e+01 9.737797e+01 1.517285e+01
## FEV1_FVC_ratio_post -15.023526 7.131089e-01 7.832420e-01 1.156789e-01
## Overall sd p.value
## pack_years 1.338584e+01 6.727853e-123
## Age 1.562341e+01 3.700565e-66
## onset_age_asthma 1.728090e+01 4.532632e-55
## Neutrophiles 1.348758e+00 1.045599e-34
## Monocytes 1.522671e-01 5.708479e-33
## BMI 4.664452e+00 3.962492e-26
## Basophiles 4.440150e-02 8.500592e-21
## pd20 2.586920e+03 2.260564e-05
## Lymphocytes 6.490450e-01 5.904570e-05
## Reversibility 6.697326e+00 2.300801e-03
## Eosinophiles 1.488999e-01 6.820330e-03
## FeNO 1.913459e+01 9.944666e-07
## tlco 2.019103e+01 1.776549e-38
## kco 1.501340e+01 1.849726e-40
## FEV1_FVC_ratio_post 8.770554e-02 5.149385e-51
##
## $`2`
## v.test Mean in category Overall mean sd in category
## kco 12.391022 1.041785e+02 9.737797e+01 1.431003e+01
## tlco 7.670168 1.054739e+02 9.981259e+01 1.493185e+01
## FEV1_FVC_ratio_post 3.912786 7.957870e-01 7.832420e-01 8.582931e-02
## onset_age_asthma 3.039103 1.469154e+01 1.277169e+01 1.201634e+01
## Reversibility 2.209226 6.488984e+00 5.948107e+00 5.977188e+00
## Basophiles -2.241459 2.416252e-02 2.780071e-02 4.230608e-02
## BMI -2.978357 2.610768e+01 2.661552e+01 4.617137e+00
## Eosinophiles -4.031651 1.784743e-01 2.004192e-01 1.156150e-01
## pd20 -4.999489 1.848170e+03 2.320957e+03 2.537685e+03
## Monocytes -5.239165 3.904312e-01 4.195937e-01 1.297842e-01
## FeNO -5.251380 1.938756e+01 2.306080e+01 9.615339e+00
## pack_years -9.344337 6.713031e+00 1.128550e+01 1.129113e+01
## Age -17.530015 4.046766e+01 5.047952e+01 1.302963e+01
## Overall sd p.value
## kco 1.501340e+01 2.922960e-35
## tlco 2.019103e+01 1.717719e-14
## FEV1_FVC_ratio_post 8.770554e-02 9.123731e-05
## onset_age_asthma 1.728090e+01 2.372835e-03
## Reversibility 6.697326e+00 2.715891e-02
## Basophiles 4.440150e-02 2.499634e-02
## BMI 4.664452e+00 2.897983e-03
## Eosinophiles 1.488999e-01 5.538648e-05
## pd20 2.586920e+03 5.748256e-07
## Monocytes 1.522671e-01 1.613046e-07
## FeNO 1.913459e+01 1.509635e-07
## pack_years 1.338584e+01 9.246685e-21
## Age 1.562341e+01 8.454732e-69
##
## $`3`
## v.test Mean in category Overall mean sd in category
## Age 20.940636 6.120391e+01 5.047952e+01 1.006836e+01
## pd20 10.155882 3.182164e+03 2.320957e+03 2.824223e+03
## pack_years 6.706068 1.422803e+01 1.128550e+01 1.086661e+01
## Monocytes 3.816963 4.386453e-01 4.195937e-01 1.417054e-01
## Basophiles -2.778288 2.375698e-02 2.780071e-02 4.090105e-02
## Eosinophiles -4.544023 1.782402e-01 2.004192e-01 1.075566e-01
## FeNO -5.087744 1.986962e+01 2.306080e+01 1.006062e+01
## Reversibility -8.952966 3.982598e+00 5.948107e+00 4.457311e+00
## tlco -11.453183 9.223220e+01 9.981259e+01 1.234813e+01
## kco -15.731394 8.963597e+01 9.737797e+01 1.186976e+01
## onset_age_asthma -20.169496 1.346369e+00 1.277169e+01 6.188169e+00
## Overall sd p.value
## Age 15.6234094 2.283907e-97
## pd20 2586.9202764 3.119757e-24
## pack_years 13.3858429 1.999392e-11
## Monocytes 0.1522671 1.351042e-04
## Basophiles 0.0444015 5.464617e-03
## Eosinophiles 0.1488999 5.519051e-06
## FeNO 19.1345916 3.623474e-07
## Reversibility 6.6973257 3.460570e-19
## tlco 20.1910322 2.266664e-30
## kco 15.0134018 9.216023e-56
## onset_age_asthma 17.2809024 1.814799e-90
##
## $`4`
## v.test Mean in category Overall mean sd in category
## FeNO 37.123331 6.541182e+01 2.306080e+01 3.472952e+01
## Eosinophiles 24.690781 4.196124e-01 2.004192e-01 2.527796e-01
## Reversibility 19.693005 1.381152e+01 5.948107e+00 1.127481e+01
## onset_age_asthma 8.531806 2.156202e+01 1.277169e+01 1.788264e+01
## tlco 8.108144 1.095732e+02 9.981259e+01 4.248197e+01
## kco 6.582396 1.032699e+02 9.737797e+01 1.420292e+01
## Basophiles 6.467751 4.492248e-02 2.780071e-02 5.152137e-02
## Age -1.967016 4.864729e+01 5.047952e+01 1.472367e+01
## pack_years -2.710664 9.122190e+00 1.128550e+01 9.177746e+00
## Neutrophiles -3.086830 3.509225e+00 3.757449e+00 1.142630e+00
## pd20 -5.837406 1.420629e+03 2.320957e+03 1.619806e+03
## FEV1_FVC_ratio_post -7.129559 7.459610e-01 7.832420e-01 9.534686e-02
## Overall sd p.value
## FeNO 1.913459e+01 1.181178e-301
## Eosinophiles 1.488999e-01 1.343412e-134
## Reversibility 6.697326e+00 2.475581e-86
## onset_age_asthma 1.728090e+01 1.440803e-17
## tlco 2.019103e+01 5.139878e-16
## kco 1.501340e+01 4.629264e-11
## Basophiles 4.440150e-02 9.947213e-11
## Age 1.562341e+01 4.918139e-02
## pack_years 1.338584e+01 6.714873e-03
## Neutrophiles 1.348758e+00 2.023033e-03
## pd20 2.586920e+03 5.301975e-09
## FEV1_FVC_ratio_post 8.770554e-02 1.006910e-12
##
## $`5`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 23.821373 31.00228311 12.77168655 18.02262643
## Age 12.859064 59.37671233 50.47952273 10.46158907
## BMI 9.203802 28.51675866 26.61552466 5.04409457
## pack_years 6.461993 15.11621689 11.28550145 14.23767899
## Neutrophiles 5.402326 4.08013699 3.75744921 1.33447627
## Basophiles 3.719261 0.03511416 0.02780071 0.04739189
## Monocytes 2.975368 0.43965753 0.41959368 0.17362933
## Reversibility 2.558108 6.70683837 5.94810721 6.56032288
## kco -2.804973 95.51298630 97.37797170 15.18505709
## tlco -5.000204 95.34149550 99.81259097 15.71380109
## FEV1_FVC_ratio_post -8.337979 0.75085613 0.78324199 0.09124828
## Overall sd p.value
## onset_age_asthma 17.28090242 2.005940e-125
## Age 15.62340943 7.649758e-38
## BMI 4.66445192 3.455033e-20
## pack_years 13.38584294 1.033328e-10
## Neutrophiles 1.34875804 6.578226e-08
## Basophiles 0.04440150 1.998061e-04
## Monocytes 0.15226706 2.926371e-03
## Reversibility 6.69732567 1.052435e-02
## kco 15.01340179 5.032083e-03
## tlco 20.19103220 5.726963e-07
## FEV1_FVC_ratio_post 0.08770554 7.557111e-171.4.3 Radar Plots
1.4.4 parallel box plots
1.4.5 parallel coordinate plot
1.5 Deep Empedding Clustering on the encoded data 4 clusters
1.5.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=672) | 1 (N=815) | 2 (N=830) | 3 (N=784) | Total (N=3101) | p value | |
|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||
| Â Â Â Mean (SD) | 62.469 (10.279) | 38.910 (11.631) | 61.171 (10.414) | 40.911 (12.049) | 50.480 (15.626) | |
| Â Â Â Range | 18.000 - 86.000 | 17.000 - 76.000 | 20.000 - 97.000 | 17.000 - 77.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | |||||
| Â Â Â No | 272 (40.5%) | 353 (43.3%) | 433 (52.2%) | 276 (35.2%) | 1334 (43.0%) | |
| Â Â Â Yes | 400 (59.5%) | 462 (56.7%) | 397 (47.8%) | 508 (64.8%) | 1767 (57.0%) | |
| BMI | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.261 (4.847) | 24.962 (4.018) | 27.143 (4.405) | 26.365 (4.815) | 26.616 (4.665) | |
| Â Â Â Range | 17.603 - 50.058 | 16.975 - 44.816 | 17.296 - 48.870 | 16.534 - 48.919 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||
| Â Â Â Mean (SD) | 35.225 (18.195) | 2.526 (6.884) | 3.659 (10.386) | 13.824 (10.221) | 12.772 (17.284) | |
| Â Â Â Range | -1.000 - 72.000 | -1.000 - 46.000 | -1.000 - 70.000 | -1.000 - 57.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||
| Â Â Â No | 388 (57.7%) | 695 (85.3%) | 672 (81.0%) | 533 (68.0%) | 2288 (73.8%) | |
| Â Â Â Yes | 284 (42.3%) | 120 (14.7%) | 158 (19.0%) | 251 (32.0%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | |||||
| Â Â Â No | 179 (26.6%) | 661 (81.1%) | 646 (77.8%) | 183 (23.3%) | 1669 (53.8%) | |
| Â Â Â Yes | 493 (73.4%) | 154 (18.9%) | 184 (22.2%) | 601 (76.7%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | |||||
| Â Â Â No | 453 (67.4%) | 786 (96.4%) | 763 (91.9%) | 646 (82.4%) | 2648 (85.4%) | |
| Â Â Â Yes | 219 (32.6%) | 29 (3.6%) | 67 (8.1%) | 138 (17.6%) | 453 (14.6%) | |
| dyspenea | < 0.001 | |||||
| Â Â Â No | 418 (62.2%) | 786 (96.4%) | 759 (91.4%) | 673 (85.8%) | 2636 (85.0%) | |
| Â Â Â Yes | 254 (37.8%) | 29 (3.6%) | 71 (8.6%) | 111 (14.2%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | |||||
| Â Â Â No | 437 (65.0%) | 777 (95.3%) | 719 (86.6%) | 662 (84.4%) | 2595 (83.7%) | |
| Â Â Â Yes | 235 (35.0%) | 38 (4.7%) | 111 (13.4%) | 122 (15.6%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.726 (0.109) | 0.828 (0.057) | 0.775 (0.078) | 0.795 (0.072) | 0.783 (0.088) | |
| Â Â Â Range | 0.259 - 1.590 | 0.596 - 1.180 | 0.230 - 1.009 | 0.524 - 1.009 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||
| Â Â Â Mean (SD) | 9.223 (9.522) | 3.794 (3.383) | 4.575 (5.395) | 6.834 (6.358) | 5.948 (6.698) | |
| Â Â Â Range | -12.121 - 77.242 | -12.603 - 21.905 | -6.583 - 43.223 | -26.774 - 53.704 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||
| Â Â Â Mean (SD) | 2615.333 (2082.149) | 2030.371 (2867.315) | 3006.962 (2672.929) | 1644.455 (2357.504) | 2320.957 (2587.337) | |
| Â Â Â Range | -3701.250 - 13923.750 | -26261.250 - 25908.750 | 0.000 - 38775.000 | -6521.250 - 38775.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||
| Â Â Â Mean (SD) | 90.225 (15.728) | 108.402 (24.278) | 91.151 (14.367) | 108.271 (16.261) | 99.813 (20.194) | |
| Â Â Â Range | 44.477 - 139.574 | 72.472 - 680.093 | 44.453 - 264.519 | 77.415 - 389.709 | 44.453 - 680.093 | |
| kco | < 0.001 | |||||
| Â Â Â Mean (SD) | 91.369 (15.425) | 102.758 (12.164) | 88.826 (12.490) | 105.989 (12.527) | 97.378 (15.016) | |
| Â Â Â Range | 40.972 - 139.418 | 28.161 - 139.983 | 47.025 - 141.410 | 60.955 - 149.720 | 28.161 - 149.720 | |
| FeNO | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.575 (26.771) | 18.557 (12.048) | 20.945 (13.512) | 25.256 (20.854) | 23.061 (19.138) | |
| Â Â Â Range | 4.300 - 203.000 | 0.000 - 119.000 | 3.400 - 138.000 | 3.300 - 226.000 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.253 (0.177) | 0.163 (0.136) | 0.193 (0.126) | 0.202 (0.145) | 0.200 (0.149) | |
| Â Â Â Range | 0.000 - 1.200 | 0.000 - 2.300 | 0.000 - 0.900 | 0.000 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 4.193 (1.460) | 3.378 (1.149) | 3.893 (1.401) | 3.635 (1.257) | 3.757 (1.349) | |
| Â Â Â Range | 1.300 - 12.500 | 0.700 - 10.000 | 1.500 - 11.500 | 1.000 - 10.600 | 0.700 - 12.500 | |
| Lymphocyties | 0.001 | |||||
| Â Â Â Mean (SD) | 2.013 (0.815) | 1.906 (0.528) | 2.007 (0.673) | 1.931 (0.567) | 1.962 (0.649) | |
| Â Â Â Range | 0.300 - 11.200 | 0.300 - 4.000 | 0.400 - 8.000 | 0.600 - 5.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.462 (0.172) | 0.372 (0.124) | 0.460 (0.162) | 0.391 (0.127) | 0.420 (0.152) | |
| Â Â Â Range | 0.200 - 2.400 | 0.190 - 1.000 | 0.200 - 1.500 | 0.100 - 1.100 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.042 (0.051) | 0.017 (0.035) | 0.028 (0.044) | 0.027 (0.044) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.190 | 0.000 - 0.250 | 0.000 - 0.200 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||
| Â Â Â No | 380 (56.5%) | 190 (23.3%) | 181 (21.8%) | 193 (24.6%) | 944 (30.4%) | |
| Â Â Â Yes | 292 (43.5%) | 625 (76.7%) | 649 (78.2%) | 591 (75.4%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | |||||
| Â Â Â No | 452 (67.3%) | 456 (56.0%) | 649 (78.2%) | 280 (35.7%) | 1837 (59.2%) | |
| Â Â Â Yes | 220 (32.7%) | 359 (44.0%) | 181 (21.8%) | 504 (64.3%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | |||||
| Â Â Â No | 623 (92.7%) | 806 (98.9%) | 811 (97.7%) | 744 (94.9%) | 2984 (96.2%) | |
| Â Â Â Yes | 49 (7.3%) | 9 (1.1%) | 19 (2.3%) | 40 (5.1%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | |||||
| Â Â Â No | 338 (50.3%) | 491 (60.2%) | 418 (50.4%) | 486 (62.0%) | 1733 (55.9%) | |
| Â Â Â Yes | 334 (49.7%) | 324 (39.8%) | 412 (49.6%) | 298 (38.0%) | 1368 (44.1%) | |
| Ever_rhinitis | 0.009 | |||||
| Â Â Â No | 179 (26.6%) | 261 (32.0%) | 211 (25.4%) | 240 (30.6%) | 891 (28.7%) | |
| Â Â Â Yes | 493 (73.4%) | 554 (68.0%) | 619 (74.6%) | 544 (69.4%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | |||||
| Â Â Â onlys saba or non users | 404 (60.1%) | 731 (89.7%) | 728 (87.7%) | 489 (62.4%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 134 (19.9%) | 52 (6.4%) | 44 (5.3%) | 179 (22.8%) | 409 (13.2%) | |
| Â Â Â step3 | 36 (5.4%) | 17 (2.1%) | 19 (2.3%) | 46 (5.9%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 98 (14.6%) | 15 (1.8%) | 39 (4.7%) | 70 (8.9%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | |||||
| Â Â Â No | 619 (92.1%) | 790 (96.9%) | 767 (92.4%) | 762 (97.2%) | 2938 (94.7%) | |
| Â Â Â Yes | 53 (7.9%) | 25 (3.1%) | 63 (7.6%) | 22 (2.8%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | |||||
| Â Â Â No | 516 (76.8%) | 750 (92.0%) | 690 (83.1%) | 684 (87.2%) | 2640 (85.1%) | |
| Â Â Â Yes | 156 (23.2%) | 65 (8.0%) | 140 (16.9%) | 100 (12.8%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | |||||
| Â Â Â No | 508 (75.6%) | 777 (95.3%) | 762 (91.8%) | 661 (84.3%) | 2708 (87.3%) | |
| Â Â Â Yes | 164 (24.4%) | 38 (4.7%) | 68 (8.2%) | 123 (15.7%) | 393 (12.7%) | |
| gina_control | < 0.001 | |||||
| Â Â Â controlled | 179 (26.6%) | 478 (58.7%) | 385 (46.4%) | 302 (38.5%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 357 (53.1%) | 291 (35.7%) | 359 (43.3%) | 384 (49.0%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 136 (20.2%) | 46 (5.6%) | 86 (10.4%) | 98 (12.5%) | 366 (11.8%) | |
| education | < 0.001 | |||||
| Â Â Â primary | 262 (39.0%) | 476 (58.4%) | 295 (35.5%) | 458 (58.4%) | 1491 (48.1%) | |
| Â Â Â secondary | 263 (39.1%) | 305 (37.4%) | 359 (43.3%) | 295 (37.6%) | 1222 (39.4%) | |
| Â Â Â tertiary | 147 (21.9%) | 34 (4.2%) | 176 (21.2%) | 31 (4.0%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | |||||
| Â Â Â No | 399 (59.4%) | 282 (34.6%) | 261 (31.4%) | 442 (56.4%) | 1384 (44.6%) | |
| Â Â Â Yes | 273 (40.6%) | 533 (65.4%) | 569 (68.6%) | 342 (43.6%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | |||||
| Â Â Â never smoker | 258 (38.4%) | 588 (72.1%) | 295 (35.5%) | 541 (69.0%) | 1682 (54.2%) | |
| Â Â Â former smokers | 343 (51.0%) | 190 (23.3%) | 414 (49.9%) | 201 (25.6%) | 1148 (37.0%) | |
| Â Â Â current smoker | 71 (10.6%) | 37 (4.5%) | 121 (14.6%) | 42 (5.4%) | 271 (8.7%) | |
| pack_years | < 0.001 | |||||
| Â Â Â Mean (SD) | 20.171 (16.126) | 3.873 (4.020) | 17.166 (15.221) | 5.150 (5.040) | 11.286 (13.388) | |
| Â Â Â Range | 0.000 - 111.000 | 0.000 - 27.000 | 0.000 - 112.500 | 0.000 - 34.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | |||||
| Â Â Â No | 195 (29.0%) | 406 (49.8%) | 240 (28.9%) | 343 (43.8%) | 1184 (38.2%) | |
| Â Â Â Yes | 477 (71.0%) | 409 (50.2%) | 590 (71.1%) | 441 (56.2%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | |||||
| Â Â Â No | 295 (43.9%) | 672 (82.5%) | 318 (38.3%) | 576 (73.5%) | 1861 (60.0%) | |
| Â Â Â Yes | 377 (56.1%) | 143 (17.5%) | 512 (61.7%) | 208 (26.5%) | 1240 (40.0%) | |
| household_damage | < 0.001 | |||||
| Â Â Â No | 602 (89.6%) | 692 (84.9%) | 764 (92.0%) | 674 (86.0%) | 2732 (88.1%) | |
| Â Â Â Yes | 70 (10.4%) | 123 (15.1%) | 66 (8.0%) | 110 (14.0%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 176 (26.2%) | 815 (100.0%) | 830 (100.0%) | 78 (9.9%) | 1899 (61.2%) | |
| Â Â Â Yes | 496 (73.8%) | 0 (0.0%) | 0 (0.0%) | 706 (90.1%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 173 (25.7%) | 815 (100.0%) | 830 (100.0%) | 109 (13.9%) | 1927 (62.1%) | |
| Â Â Â Yes | 499 (74.3%) | 0 (0.0%) | 0 (0.0%) | 675 (86.1%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 477 (71.0%) | 799 (98.0%) | 824 (99.3%) | 438 (55.9%) | 2538 (81.8%) | |
| Â Â Â Yes | 195 (29.0%) | 16 (2.0%) | 6 (0.7%) | 346 (44.1%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 550 (81.8%) | 813 (99.8%) | 827 (99.6%) | 626 (79.8%) | 2816 (90.8%) | |
| Â Â Â Yes | 122 (18.2%) | 2 (0.2%) | 3 (0.4%) | 158 (20.2%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 426 (63.4%) | 812 (99.6%) | 828 (99.8%) | 423 (54.0%) | 2489 (80.3%) | |
| Â Â Â Yes | 246 (36.6%) | 3 (0.4%) | 2 (0.2%) | 361 (46.0%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 600 (89.3%) | 815 (100.0%) | 830 (100.0%) | 691 (88.1%) | 2936 (94.7%) | |
| Â Â Â Yes | 72 (10.7%) | 0 (0.0%) | 0 (0.0%) | 93 (11.9%) | 165 (5.3%) | |
| XCOPD | < 0.001 | |||||
| Â Â Â No | 497 (74.0%) | 806 (98.9%) | 772 (93.0%) | 752 (95.9%) | 2827 (91.2%) | |
| Â Â Â Yes | 175 (26.0%) | 9 (1.1%) | 58 (7.0%) | 32 (4.1%) | 274 (8.8%) |
1.5.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## exertion_triggered_asthma 0.000000e+00 3
## infection_triggered_asthma 0.000000e+00 3
## Breathlessness 3.609347e-201 3
## weather_triggered_asthma 4.012776e-185 3
## allergen_triggered_asthma 2.205621e-156 3
## smoking_exposure_at_work 1.250083e-100 3
## dyspenea 3.562300e-83 3
## smoking_status 2.665262e-76 6
## irritant_triggered_asthma 6.296259e-72 3
## XCOPD 7.259841e-72 3
## familial_allergy 4.406266e-70 3
## gina_steps 3.564052e-68 9
## Recurrent_wheeze 3.919089e-62 3
## spt_any 6.897208e-60 3
## Chronic_productive_cough 1.280331e-55 3
## education 8.752188e-55 6
## emotion_triggered_asthma 1.234757e-42 3
## urbanization_level 6.641859e-42 3
## Cough 5.814887e-39 3
## gina_control 1.800880e-38 6
## severe_asthma 8.318435e-33 3
## smoking_exposure_at_home 6.245979e-24 3
## Emergency_last_year 9.878637e-16 3
## Gender 9.340985e-11 3
## Drug_induced_dyspnea 2.405209e-10 3
## nasal_plyposis 4.788979e-08 3
## Hosptalization_last_year 8.628838e-08 3
## household_damage 1.494338e-05 3
## Ever_rhinitis 9.092898e-03 3
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 42.504259 74.255952 37.858755 1.636325e-105
## exertion_triggered_asthma=Yes 41.264559 73.809524 38.761690 1.667342e-97
## dyspenea=Yes 54.623656 37.797619 14.995163 3.750964e-66
## Breathlessness=Yes 34.427374 73.363095 46.178652 1.697541e-58
## spt_any=No 40.254237 56.547619 30.441793 3.771739e-58
## XCOPD=Yes 63.868613 26.041667 8.835859 4.180421e-57
## Recurrent_wheeze=Yes 48.344371 32.589286 14.608191 2.361370e-43
## Chronic_productive_cough=Yes 46.442688 34.970238 16.317317 3.650372e-43
## weather_triggered_asthma=Yes 40.196078 36.607143 19.735569 6.007724e-32
## Cough=Yes 34.932349 42.261905 26.217349 5.713729e-25
## severe_asthma=Yes 41.730280 24.404762 12.673331 4.591186e-22
## smoking_exposure_at_work=Yes 30.403226 56.101190 39.987101 1.384253e-21
## urbanization_level=No 28.829480 59.375000 44.630764 4.569262e-18
## irritant_triggered_asthma=Yes 42.807018 18.154762 9.190584 3.217534e-17
## smoking_status=former smokers 29.878049 51.041667 37.020316 4.770906e-17
## allergen_triggered_asthma=Yes 34.635879 29.017857 18.155434 2.772759e-15
## education=tertiary 37.886598 21.875000 12.512093 5.227362e-15
## gina_steps=step4 or 5 44.144144 14.583333 7.158981 6.879842e-15
## gina_control=uncontrolled 37.158470 20.238095 11.802644 4.658254e-13
## Emergency_last_year=Yes 33.839479 23.214286 14.866172 4.917125e-11
## emotion_triggered_asthma=Yes 43.636364 10.714286 5.320864 8.578891e-11
## gina_steps=step 1 or 2 32.762836 19.940476 13.189294 2.143941e-08
## smoking_exposure_at_home=Yes 24.882629 70.982143 61.818768 2.209424e-08
## Drug_induced_dyspnea=Yes 41.880342 7.291667 3.772976 5.708193e-07
## gina_control=partially controlled 25.664989 53.125000 44.856498 1.208075e-06
## familial_allergy=No 24.605335 67.261905 59.238955 1.428269e-06
## Hosptalization_last_year=Yes 32.515337 7.886905 5.256369 9.808050e-04
## nasal_plyposis=Yes 24.415205 49.702381 44.114802 1.016306e-03
## gina_steps=step3 30.508475 5.357143 3.805224 2.218019e-02
## nasal_plyposis=No 19.503751 50.297619 55.885198 1.016306e-03
## Hosptalization_last_year=No 21.068754 92.113095 94.743631 9.808050e-04
## familial_allergy=Yes 17.405063 32.738095 40.761045 1.428269e-06
## Drug_induced_dyspnea=No 20.878016 92.708333 96.227024 5.708193e-07
## education=primary 17.572099 38.988095 48.081264 8.992532e-08
## smoking_exposure_at_home=No 16.469595 29.017857 38.181232 2.209424e-08
## emotion_triggered_asthma=No 20.435967 89.285714 94.679136 8.578891e-11
## Emergency_last_year=No 19.545455 76.785714 85.133828 4.917125e-11
## allergen_triggered_asthma=No 18.794326 70.982143 81.844566 2.772759e-15
## irritant_triggered_asthma=No 19.531250 81.845238 90.809416 3.217534e-17
## urbanization_level=Yes 15.899825 40.625000 55.369236 4.569262e-18
## smoking_status=never smoker 15.338882 38.392857 54.240568 1.269381e-20
## smoking_exposure_at_work=No 15.851693 43.898810 60.012899 1.384253e-21
## severe_asthma=No 18.759232 75.595238 87.326669 4.591186e-22
## gina_control=controlled 13.318452 26.636905 43.340858 8.283535e-24
## Cough=No 16.958042 57.738095 73.782651 5.713729e-25
## gina_steps=onlys saba or non users 17.176871 60.119048 75.846501 4.208710e-25
## weather_triggered_asthma=No 17.115307 63.392857 80.264431 6.007724e-32
## Chronic_productive_cough=No 16.840077 65.029762 83.682683 3.650372e-43
## Recurrent_wheeze=No 17.107251 67.410714 85.391809 2.361370e-43
## XCOPD=No 17.580474 73.958333 91.164141 4.180421e-57
## spt_any=Yes 13.537320 43.452381 69.558207 3.771739e-58
## Breathlessness=No 10.724985 26.636905 53.821348 1.697541e-58
## dyspenea=No 15.857360 62.202381 85.004837 3.750964e-66
## exertion_triggered_asthma=No 9.268036 26.190476 61.238310 1.667342e-97
## infection_triggered_asthma=No 8.977686 25.744048 62.141245 1.636325e-105
## v.test
## infection_triggered_asthma=Yes 21.815978
## exertion_triggered_asthma=Yes 20.955623
## dyspenea=Yes 17.179971
## Breathlessness=Yes 16.125183
## spt_any=No 16.075787
## XCOPD=Yes 15.926034
## Recurrent_wheeze=Yes 13.805497
## Chronic_productive_cough=Yes 13.774073
## weather_triggered_asthma=Yes 11.763653
## Cough=Yes 10.320144
## severe_asthma=Yes 9.656998
## smoking_exposure_at_work=Yes 9.543250
## urbanization_level=No 8.663642
## irritant_triggered_asthma=Yes 8.438385
## smoking_status=former smokers 8.392209
## allergen_triggered_asthma=Yes 7.900729
## education=tertiary 7.821317
## gina_steps=step4 or 5 7.786670
## gina_control=uncontrolled 7.234914
## Emergency_last_year=Yes 6.573424
## emotion_triggered_asthma=Yes 6.490083
## gina_steps=step 1 or 2 5.599966
## smoking_exposure_at_home=Yes 5.594748
## Drug_induced_dyspnea=Yes 5.000837
## gina_control=partially controlled 4.854309
## familial_allergy=No 4.821019
## Hosptalization_last_year=Yes 3.295976
## nasal_plyposis=Yes 3.285973
## gina_steps=step3 2.287268
## nasal_plyposis=No -3.285973
## Hosptalization_last_year=No -3.295976
## familial_allergy=Yes -4.821019
## Drug_induced_dyspnea=No -5.000837
## education=primary -5.345988
## smoking_exposure_at_home=No -5.594748
## emotion_triggered_asthma=No -6.490083
## Emergency_last_year=No -6.573424
## allergen_triggered_asthma=No -7.900729
## irritant_triggered_asthma=No -8.438385
## urbanization_level=Yes -8.663642
## smoking_status=never smoker -9.310746
## smoking_exposure_at_work=No -9.543250
## severe_asthma=No -9.656998
## gina_control=controlled -10.060194
## Cough=No -10.320144
## gina_steps=onlys saba or non users -10.349456
## weather_triggered_asthma=No -11.763653
## Chronic_productive_cough=No -13.774073
## Recurrent_wheeze=No -13.805497
## XCOPD=No -15.926034
## spt_any=Yes -16.075787
## Breathlessness=No -16.125183
## dyspenea=No -17.179971
## exertion_triggered_asthma=No -20.955623
## infection_triggered_asthma=No -21.815978
##
## $`1`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 42.9173249 100.0000000 61.238310
## infection_triggered_asthma=No 42.2937208 100.0000000 62.141245
## weather_triggered_asthma=No 32.6235436 99.6319018 80.264431
## Breathlessness=No 39.6045536 81.1042945 53.821348
## allergen_triggered_asthma=No 31.4814815 98.0368098 81.844566
## smoking_exposure_at_work=No 36.1096185 82.4539877 60.012899
## irritant_triggered_asthma=No 28.8707386 99.7546012 90.809416
## smoking_status=never smoker 34.9583829 72.1472393 54.240568
## dyspenea=No 29.8179059 96.4417178 85.004837
## Recurrent_wheeze=No 29.6827795 96.4417178 85.391809
## Chronic_productive_cough=No 29.9421965 95.3374233 83.682683
## gina_steps=onlys saba or non users 31.0799320 89.6932515 75.846501
## XCOPD=No 28.5107888 98.8957055 91.164141
## gina_control=controlled 35.5654762 58.6503067 43.340858
## emotion_triggered_asthma=No 27.7588556 100.0000000 94.679136
## Cough=No 30.3758741 85.2760736 73.782651
## severe_asthma=No 28.6927622 95.3374233 87.326669
## smoking_exposure_at_home=No 34.2905405 49.8159509 38.181232
## education=primary 31.9248826 58.4049080 48.081264
## Emergency_last_year=No 28.4090909 92.0245399 85.133828
## urbanization_level=Yes 31.0425160 65.3987730 55.369236
## spt_any=Yes 28.9754288 76.6871166 69.558207
## Drug_induced_dyspnea=No 27.0107239 98.8957055 96.227024
## Hosptalization_last_year=No 26.8890402 96.9325153 94.743631
## household_damage=Yes 33.3333333 15.0920245 11.899387
## nasal_plyposis=No 28.3323716 60.2453988 55.885198
## Ever_rhinitis=No 29.2929293 32.0245399 28.732667
## familial_allergy=Yes 28.4018987 44.0490798 40.761045
## familial_allergy=No 24.8230811 55.9509202 59.238955
## Ever_rhinitis=Yes 25.0678733 67.9754601 71.267333
## nasal_plyposis=Yes 23.6842105 39.7546012 44.114802
## gina_steps=step3 14.4067797 2.0858896 3.805224
## household_damage=No 25.3294290 84.9079755 88.100613
## Hosptalization_last_year=Yes 15.3374233 3.0674847 5.256369
## Drug_induced_dyspnea=Yes 7.6923077 1.1042945 3.772976
## smoking_status=current smoker 13.6531365 4.5398773 8.739116
## spt_any=No 20.1271186 23.3128834 30.441793
## gina_control=partially controlled 20.9202013 35.7055215 44.856498
## urbanization_level=No 20.3757225 34.6012270 44.630764
## gina_control=uncontrolled 12.5683060 5.6441718 11.802644
## Emergency_last_year=Yes 14.0997831 7.9754601 14.866172
## gina_steps=step 1 or 2 12.7139364 6.3803681 13.189294
## gina_steps=step4 or 5 6.7567568 1.8404908 7.158981
## smoking_exposure_at_home=Yes 21.3354199 50.1840491 61.818768
## severe_asthma=Yes 9.6692112 4.6625767 12.673331
## Cough=Yes 14.7601476 14.7239264 26.217349
## education=tertiary 8.7628866 4.1717791 12.512093
## smoking_status=former smokers 16.5505226 23.3128834 37.020316
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## XCOPD=Yes 3.2846715 1.1042945 8.835859
## Chronic_productive_cough=Yes 7.5098814 4.6625767 16.317317
## Recurrent_wheeze=Yes 6.4017660 3.5582822 14.608191
## dyspenea=Yes 6.2365591 3.5582822 14.995163
## irritant_triggered_asthma=Yes 0.7017544 0.2453988 9.190584
## smoking_exposure_at_work=Yes 11.5322581 17.5460123 39.987101
## allergen_triggered_asthma=Yes 2.8419183 1.9631902 18.155434
## Breathlessness=Yes 10.7541899 18.8957055 46.178652
## weather_triggered_asthma=Yes 0.4901961 0.3680982 19.735569
## infection_triggered_asthma=Yes 0.0000000 0.0000000 37.858755
## exertion_triggered_asthma=Yes 0.0000000 0.0000000 38.761690
## p.value v.test
## exertion_triggered_asthma=No 5.057859e-213 31.150090
## infection_triggered_asthma=No 2.837805e-206 30.647678
## weather_triggered_asthma=No 3.223565e-86 19.679629
## Breathlessness=No 9.995855e-79 18.785121
## allergen_triggered_asthma=No 3.530455e-59 16.221910
## smoking_exposure_at_work=No 1.810996e-56 15.834076
## irritant_triggered_asthma=No 8.318905e-37 12.673255
## smoking_status=never smoker 7.195365e-34 12.131462
## dyspenea=No 1.031793e-32 11.911440
## Recurrent_wheeze=No 3.299456e-31 11.619008
## Chronic_productive_cough=No 6.157732e-31 11.565575
## gina_steps=onlys saba or non users 2.847947e-30 11.433382
## XCOPD=No 3.480415e-26 10.585467
## gina_control=controlled 1.360466e-24 10.236517
## emotion_triggered_asthma=No 2.784060e-23 9.940151
## Cough=No 1.577159e-19 9.039274
## severe_asthma=No 3.317662e-18 8.700040
## smoking_exposure_at_home=No 3.014976e-15 7.890285
## education=primary 6.346658e-12 6.871643
## Emergency_last_year=No 1.218839e-11 6.777961
## urbanization_level=Yes 1.455686e-11 6.752251
## spt_any=Yes 1.694304e-07 5.230087
## Drug_induced_dyspnea=No 2.571554e-07 5.152413
## Hosptalization_last_year=No 6.573808e-04 3.406763
## household_damage=Yes 1.332574e-03 3.208871
## nasal_plyposis=No 3.450441e-03 2.924469
## Ever_rhinitis=No 1.626473e-02 2.402920
## familial_allergy=Yes 2.650460e-02 2.218737
## familial_allergy=No 2.650460e-02 -2.218737
## Ever_rhinitis=Yes 1.626473e-02 -2.402920
## nasal_plyposis=Yes 3.450441e-03 -2.924469
## gina_steps=step3 1.738733e-03 -3.131572
## household_damage=No 1.332574e-03 -3.208871
## Hosptalization_last_year=Yes 6.573808e-04 -3.406763
## Drug_induced_dyspnea=Yes 2.571554e-07 -5.152413
## smoking_status=current smoker 1.699591e-07 -5.229511
## spt_any=No 1.694304e-07 -5.230087
## gina_control=partially controlled 7.697528e-10 -6.151043
## urbanization_level=No 1.455686e-11 -6.752251
## gina_control=uncontrolled 1.424306e-11 -6.755411
## Emergency_last_year=Yes 1.218839e-11 -6.777961
## gina_steps=step 1 or 2 1.164845e-12 -7.109476
## gina_steps=step4 or 5 1.581594e-14 -7.680750
## smoking_exposure_at_home=Yes 3.014976e-15 -7.890285
## severe_asthma=Yes 3.317662e-18 -8.700040
## Cough=Yes 1.577159e-19 -9.039274
## education=tertiary 4.416902e-20 -9.177384
## smoking_status=former smokers 4.659688e-22 -9.655481
## emotion_triggered_asthma=Yes 2.784060e-23 -9.940151
## XCOPD=Yes 3.480415e-26 -10.585467
## Chronic_productive_cough=Yes 6.157732e-31 -11.565575
## Recurrent_wheeze=Yes 3.299456e-31 -11.619008
## dyspenea=Yes 1.031793e-32 -11.911440
## irritant_triggered_asthma=Yes 8.318905e-37 -12.673255
## smoking_exposure_at_work=Yes 1.810996e-56 -15.834076
## allergen_triggered_asthma=Yes 3.530455e-59 -16.221910
## Breathlessness=Yes 9.995855e-79 -18.785121
## weather_triggered_asthma=Yes 3.223565e-86 -19.679629
## infection_triggered_asthma=Yes 2.837805e-206 -30.647678
## exertion_triggered_asthma=Yes 5.057859e-213 -31.150090
##
## $`2`
## Cla/Mod Mod/Cla Global
## exertion_triggered_asthma=No 43.7072143 100.0000000 61.238310
## infection_triggered_asthma=No 43.0721328 100.0000000 62.141245
## weather_triggered_asthma=No 33.2663720 99.7590361 80.264431
## allergen_triggered_asthma=No 32.4665091 99.2771084 81.844566
## Breathlessness=No 38.7058119 77.8313253 53.821348
## smoking_exposure_at_work=Yes 41.2903226 61.6867470 39.987101
## familial_allergy=No 35.3293413 78.1927711 59.238955
## irritant_triggered_asthma=No 29.3678977 99.6385542 90.809416
## emotion_triggered_asthma=No 28.2697548 100.0000000 94.679136
## gina_steps=onlys saba or non users 30.9523810 87.7108434 75.846501
## urbanization_level=Yes 33.1391963 68.5542169 55.369236
## smoking_status=former smokers 36.0627178 49.8795181 37.020316
## education=tertiary 45.3608247 21.2048193 12.512093
## smoking_status=current smoker 44.6494465 14.5783133 8.739116
## Recurrent_wheeze=No 28.8141994 91.9277108 85.391809
## smoking_exposure_at_home=Yes 30.7772561 71.0843373 61.818768
## spt_any=Yes 30.0880853 78.1927711 69.558207
## dyspenea=No 28.7936267 91.4457831 85.004837
## Gender=No 32.4587706 52.1686747 43.018381
## Cough=No 29.3706294 80.9638554 73.782651
## severe_asthma=No 28.1388479 91.8072289 87.326669
## household_damage=No 27.9648609 92.0481928 88.100613
## nasal_plyposis=Yes 30.1169591 49.6385542 44.114802
## Hosptalization_last_year=Yes 38.6503067 7.5903614 5.256369
## Drug_induced_dyspnea=No 27.1782842 97.7108434 96.227024
## Chronic_productive_cough=No 27.7071291 86.6265060 83.682683
## education=secondary 29.3780687 43.2530120 39.406643
## Ever_rhinitis=Yes 28.0090498 74.5783133 71.267333
## XCOPD=No 27.3081005 93.0120482 91.164141
## gina_control=controlled 28.6458333 46.3855422 43.340858
## XCOPD=Yes 21.1678832 6.9879518 8.835859
## Ever_rhinitis=No 23.6812570 25.4216867 28.732667
## Chronic_productive_cough=Yes 21.9367589 13.3734940 16.317317
## Drug_induced_dyspnea=Yes 16.2393162 2.2891566 3.772976
## gina_steps=step3 16.1016949 2.2891566 3.805224
## gina_steps=step4 or 5 17.5675676 4.6987952 7.158981
## Hosptalization_last_year=No 26.1061947 92.4096386 94.743631
## nasal_plyposis=No 24.1200231 50.3614458 55.885198
## household_damage=Yes 17.8861789 7.9518072 11.899387
## severe_asthma=Yes 17.3027990 8.1927711 12.673331
## Cough=Yes 19.4341943 19.0361446 26.217349
## Gender=Yes 22.4674590 47.8313253 56.981619
## dyspenea=Yes 15.2688172 8.5542169 14.995163
## spt_any=No 19.1737288 21.8072289 30.441793
## smoking_exposure_at_home=No 20.2702703 28.9156627 38.181232
## Recurrent_wheeze=Yes 14.7902870 8.0722892 14.608191
## gina_steps=step 1 or 2 10.7579462 5.3012048 13.189294
## education=primary 19.7853789 35.5421687 48.081264
## urbanization_level=No 18.8583815 31.4457831 44.630764
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## irritant_triggered_asthma=Yes 1.0526316 0.3614458 9.190584
## smoking_status=never smoker 17.5386445 35.5421687 54.240568
## familial_allergy=Yes 14.3196203 21.8072289 40.761045
## smoking_exposure_at_work=No 17.0875873 38.3132530 60.012899
## Breathlessness=Yes 12.8491620 22.1686747 46.178652
## allergen_triggered_asthma=Yes 1.0657194 0.7228916 18.155434
## weather_triggered_asthma=Yes 0.3267974 0.2409639 19.735569
## infection_triggered_asthma=Yes 0.0000000 0.0000000 37.858755
## exertion_triggered_asthma=Yes 0.0000000 0.0000000 38.761690
## p.value v.test
## exertion_triggered_asthma=No 6.622114e-218 31.508605
## infection_triggered_asthma=No 5.460265e-211 30.999586
## weather_triggered_asthma=No 3.147657e-90 20.142241
## allergen_triggered_asthma=No 1.290404e-74 18.275776
## Breathlessness=No 5.351465e-62 16.615846
## smoking_exposure_at_work=Yes 1.268671e-49 14.809667
## familial_allergy=No 1.321603e-40 13.341838
## irritant_triggered_asthma=No 4.712235e-36 12.536523
## emotion_triggered_asthma=No 9.017507e-24 10.051832
## gina_steps=onlys saba or non users 1.240778e-22 9.790178
## urbanization_level=Yes 1.882975e-19 9.019879
## smoking_status=former smokers 7.328986e-19 8.869781
## education=tertiary 2.959975e-17 8.448133
## smoking_status=current smoker 3.212211e-11 6.636499
## Recurrent_wheeze=No 6.239922e-11 6.537875
## smoking_exposure_at_home=Yes 8.263370e-11 6.495726
## spt_any=Yes 1.186657e-10 6.441030
## dyspenea=No 2.079078e-10 6.355383
## Gender=No 5.753453e-10 6.197041
## Cough=No 2.006003e-08 5.611483
## severe_asthma=No 2.639653e-06 4.697035
## household_damage=No 2.238556e-05 4.239663
## nasal_plyposis=Yes 1.875290e-04 3.735250
## Hosptalization_last_year=Yes 6.861382e-04 3.395059
## Drug_induced_dyspnea=No 6.552597e-03 2.718766
## Chronic_productive_cough=No 6.579870e-03 2.717392
## education=secondary 8.277946e-03 2.640518
## Ever_rhinitis=Yes 1.324858e-02 2.477016
## XCOPD=No 2.605786e-02 2.225348
## gina_control=controlled 3.898519e-02 2.064343
## XCOPD=Yes 2.605786e-02 -2.225348
## Ever_rhinitis=No 1.324858e-02 -2.477016
## Chronic_productive_cough=Yes 6.579870e-03 -2.717392
## Drug_induced_dyspnea=Yes 6.552597e-03 -2.718766
## gina_steps=step3 5.619520e-03 -2.769194
## gina_steps=step4 or 5 8.949229e-04 -3.321633
## Hosptalization_last_year=No 6.861382e-04 -3.395059
## nasal_plyposis=No 1.875290e-04 -3.735250
## household_damage=Yes 2.238556e-05 -4.239663
## severe_asthma=Yes 2.639653e-06 -4.697035
## Cough=Yes 2.006003e-08 -5.611483
## Gender=Yes 5.753453e-10 -6.197041
## dyspenea=Yes 2.079078e-10 -6.355383
## spt_any=No 1.186657e-10 -6.441030
## smoking_exposure_at_home=No 8.263370e-11 -6.495726
## Recurrent_wheeze=Yes 6.239922e-11 -6.537875
## gina_steps=step 1 or 2 2.681211e-17 -8.459676
## education=primary 1.996740e-17 -8.493983
## urbanization_level=No 1.882975e-19 -9.019879
## emotion_triggered_asthma=Yes 9.017507e-24 -10.051832
## irritant_triggered_asthma=Yes 4.712235e-36 -12.536523
## smoking_status=never smoker 1.055592e-36 -12.654565
## familial_allergy=Yes 1.321603e-40 -13.341838
## smoking_exposure_at_work=No 1.268671e-49 -14.809667
## Breathlessness=Yes 5.351465e-62 -16.615846
## allergen_triggered_asthma=Yes 1.290404e-74 -18.275776
## weather_triggered_asthma=Yes 3.147657e-90 -20.142241
## infection_triggered_asthma=Yes 5.460265e-211 -30.999586
## exertion_triggered_asthma=Yes 6.622114e-218 -31.508605
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 58.735441 90.051020 38.761690 3.257734e-268
## infection_triggered_asthma=Yes 57.495741 86.096939 37.858755 8.362839e-234
## allergen_triggered_asthma=Yes 61.456483 44.132653 18.155434 1.837599e-93
## weather_triggered_asthma=Yes 58.986928 46.045918 19.735569 7.931694e-91
## Breathlessness=Yes 41.969274 76.658163 46.178652 8.628941e-90
## familial_allergy=Yes 39.873418 64.285714 40.761045 1.155392e-53
## irritant_triggered_asthma=Yes 55.438596 20.153061 9.190584 2.788726e-30
## smoking_status=never smoker 32.164090 69.005102 54.240568 2.889241e-22
## smoking_exposure_at_work=No 30.951102 73.469388 60.012899 1.363254e-19
## gina_steps=step 1 or 2 43.765281 22.831633 13.189294 1.608466e-18
## emotion_triggered_asthma=Yes 56.363636 11.862245 5.320864 2.603446e-18
## urbanization_level=No 31.936416 56.377551 44.630764 2.292785e-14
## education=primary 30.717639 58.418367 48.081264 2.043611e-11
## XCOPD=No 26.600637 95.918367 91.164141 6.394862e-09
## Gender=Yes 28.749293 64.795918 56.981619 2.730897e-07
## Cough=Yes 30.873309 32.015306 26.217349 2.543665e-05
## spt_any=Yes 27.399166 75.382653 69.558207 3.342525e-05
## nasal_plyposis=No 28.043855 61.989796 55.885198 6.468827e-05
## Hosptalization_last_year=No 25.936011 97.193878 94.743631 1.765002e-04
## smoking_exposure_at_home=No 28.969595 43.750000 38.181232 2.225718e-04
## gina_steps=step3 38.983051 5.867347 3.805224 8.555371e-04
## severe_asthma=Yes 31.297710 15.688776 12.673331 3.978659e-03
## Recurrent_wheeze=Yes 30.463576 17.602041 14.608191 6.899233e-03
## gina_control=partially controlled 27.606039 48.979592 44.856498 7.366953e-03
## Drug_induced_dyspnea=Yes 34.188034 5.102041 3.772976 2.839729e-02
## gina_steps=step4 or 5 31.531532 8.928571 7.158981 2.940488e-02
## household_damage=Yes 29.810298 14.030612 11.899387 3.551163e-02
## household_damage=No 24.670571 85.969388 88.100613 3.551163e-02
## Drug_induced_dyspnea=No 24.932976 94.897959 96.227024 2.839729e-02
## Recurrent_wheeze=No 24.395770 82.397959 85.391809 6.899233e-03
## severe_asthma=No 24.409158 84.311224 87.326669 3.978659e-03
## gina_control=controlled 22.470238 38.520408 43.340858 1.586871e-03
## smoking_exposure_at_home=Yes 23.004695 56.250000 61.818768 2.225718e-04
## Hosptalization_last_year=Yes 13.496933 2.806122 5.256369 1.765002e-04
## nasal_plyposis=Yes 21.783626 38.010204 44.114802 6.468827e-05
## smoking_status=current smoker 15.498155 5.357143 8.739116 5.253098e-05
## spt_any=No 20.444915 24.617347 30.441793 3.342525e-05
## Cough=No 23.295455 67.984694 73.782651 2.543665e-05
## Gender=No 20.689655 35.204082 43.018381 2.730897e-07
## XCOPD=Yes 11.678832 4.081633 8.835859 6.394862e-09
## urbanization_level=Yes 19.918462 43.622449 55.369236 2.292785e-14
## smoking_status=former smokers 17.508711 25.637755 37.020316 7.688483e-15
## emotion_triggered_asthma=No 23.535422 88.137755 94.679136 2.603446e-18
## smoking_exposure_at_work=Yes 16.774194 26.530612 39.987101 1.363254e-19
## education=tertiary 7.989691 3.954082 12.512093 2.806355e-20
## gina_steps=onlys saba or non users 20.790816 62.372449 75.846501 4.909280e-23
## irritant_triggered_asthma=No 22.230114 79.846939 90.809416 2.788726e-30
## familial_allergy=No 15.242243 35.714286 59.238955 1.155392e-53
## Breathlessness=No 10.964649 23.341837 53.821348 8.628941e-90
## weather_triggered_asthma=No 16.994777 53.954082 80.264431 7.931694e-91
## allergen_triggered_asthma=No 17.257683 55.867347 81.844566 1.837599e-93
## infection_triggered_asthma=No 5.656461 13.903061 62.141245 8.362839e-234
## exertion_triggered_asthma=No 4.107425 9.948980 61.238310 3.257734e-268
## v.test
## exertion_triggered_asthma=Yes 34.989430
## infection_triggered_asthma=Yes 32.648693
## allergen_triggered_asthma=Yes 20.507706
## weather_triggered_asthma=Yes 20.210391
## Breathlessness=Yes 20.092235
## familial_allergy=Yes 15.422502
## irritant_triggered_asthma=Yes 11.435206
## smoking_status=never smoker 9.704346
## smoking_exposure_at_work=No 9.055194
## gina_steps=step 1 or 2 8.781823
## emotion_triggered_asthma=Yes 8.727508
## urbanization_level=No 7.633042
## education=primary 6.702873
## XCOPD=No 5.806090
## Gender=Yes 5.141131
## Cough=Yes 4.210890
## spt_any=Yes 4.148780
## nasal_plyposis=No 3.995022
## Hosptalization_last_year=No 3.750475
## smoking_exposure_at_home=No 3.691915
## gina_steps=step3 3.334172
## severe_asthma=Yes 2.879849
## Recurrent_wheeze=Yes 2.701669
## gina_control=partially controlled 2.679785
## Drug_induced_dyspnea=Yes 2.191754
## gina_steps=step4 or 5 2.178016
## household_damage=Yes 2.102476
## household_damage=No -2.102476
## Drug_induced_dyspnea=No -2.191754
## Recurrent_wheeze=No -2.701669
## severe_asthma=No -2.879849
## gina_control=controlled -3.158309
## smoking_exposure_at_home=Yes -3.691915
## Hosptalization_last_year=Yes -3.750475
## nasal_plyposis=Yes -3.995022
## smoking_status=current smoker -4.044071
## spt_any=No -4.148780
## Cough=No -4.210890
## Gender=No -5.141131
## XCOPD=Yes -5.806090
## urbanization_level=Yes -7.633042
## smoking_status=former smokers -7.772611
## emotion_triggered_asthma=No -8.727508
## smoking_exposure_at_work=Yes -9.055194
## education=tertiary -9.226111
## gina_steps=onlys saba or non users -9.883490
## irritant_triggered_asthma=No -11.435206
## familial_allergy=No -15.422502
## Breathlessness=No -20.092235
## weather_triggered_asthma=No -20.210391
## allergen_triggered_asthma=No -20.507706
## infection_triggered_asthma=No -32.648693
## exertion_triggered_asthma=No -34.989430
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.491909002 0.000000e+00
## onset_age_asthma 0.533577772 0.000000e+00
## pack_years 0.280844831 4.591067e-221
## kco 0.238475725 1.330375e-182
## tlco 0.190050205 3.426994e-141
## FEV1_FVC_ratio_post 0.168637048 1.141642e-123
## Reversibility 0.094693288 1.718750e-66
## Monocytes 0.070599208 6.857306e-49
## BMI 0.064135629 2.994284e-44
## Neutrophiles 0.048236905 5.544799e-33
## Eosinophiles 0.045115194 8.544977e-31
## pd20 0.042233922 8.785184e-29
## FeNO 0.039158908 1.211388e-26
## Basophiles 0.038994204 1.576344e-26
## Lymphocytes 0.005126568 1.177409e-03
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 38.050467 3.522470e+01 1.277169e+01 1.818134e+01
## Age 22.473313 6.246875e+01 5.047952e+01 1.027113e+01
## pack_years 19.439026 2.017073e+01 1.128550e+01 1.611400e+01
## Reversibility 14.321152 9.223230e+00 5.948107e+00 9.514434e+00
## Eosinophiles 10.433418 2.534673e-01 2.004192e-01 1.768795e-01
## BMI 10.330197 2.826087e+01 2.661552e+01 4.843203e+00
## Neutrophiles 9.467213 4.193467e+00 3.757449e+00 1.459152e+00
## Basophiles 9.341723 4.196429e-02 2.780071e-02 5.130742e-02
## FeNO 8.439577 2.857507e+01 2.306080e+01 2.675088e+01
## Monocytes 8.091874 4.616667e-01 4.195937e-01 1.719874e-01
## pd20 3.332513 2.615333e+03 2.320957e+03 2.080599e+03
## Lymphocytes 2.280182 2.012976e+00 1.962441e+00 8.142054e-01
## kco -11.720724 9.136925e+01 9.737797e+01 1.541368e+01
## tlco -13.905973 9.022503e+01 9.981259e+01 1.571662e+01
## FEV1_FVC_ratio_post -19.195795 7.257534e-01 7.832420e-01 1.093694e-01
## Overall sd p.value
## onset_age_asthma 1.728090e+01 0.000000e+00
## Age 1.562341e+01 7.572603e-112
## pack_years 1.338584e+01 3.609565e-84
## Reversibility 6.697326e+00 1.614246e-46
## Eosinophiles 1.488999e-01 1.744963e-25
## BMI 4.664452e+00 5.145505e-25
## Neutrophiles 1.348758e+00 2.874095e-21
## Basophiles 4.440150e-02 9.477882e-21
## FeNO 1.913459e+01 3.184887e-17
## Monocytes 1.522671e-01 5.875379e-16
## pd20 2.586920e+03 8.606542e-04
## Lymphocytes 6.490450e-01 2.259689e-02
## kco 1.501340e+01 9.981474e-32
## tlco 2.019103e+01 5.826900e-44
## FEV1_FVC_ratio_post 8.770554e-02 4.012980e-82
##
## $`1`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 17.003039 8.280992e-01 7.832420e-01 5.673454e-02
## tlco 14.142631 1.084021e+02 9.981259e+01 2.426302e+01
## kco 11.912186 1.027576e+02 9.737797e+01 1.215612e+01
## Lymphocytes -2.878393 1.906245e+00 1.962441e+00 5.272374e-01
## pd20 -3.734337 2.030371e+03 2.320957e+03 2.865556e+03
## FeNO -7.824537 1.855724e+01 2.306080e+01 1.204047e+01
## Basophiles -8.431297 1.653988e-02 2.780071e-02 3.540549e-02
## Eosinophiles -8.449038 1.625767e-01 2.004192e-01 1.355063e-01
## Neutrophiles -9.350067 3.378110e+00 3.757449e+00 1.148138e+00
## Monocytes -10.476905 3.716074e-01 4.195937e-01 1.241570e-01
## Reversibility -10.694476 3.793643e+00 5.948107e+00 3.380527e+00
## BMI -11.782491 2.496236e+01 2.661552e+01 4.015123e+00
## pack_years -18.410520 3.872566e+00 1.128550e+01 4.017500e+00
## onset_age_asthma -19.709702 2.526380e+00 1.277169e+01 6.879969e+00
## Age -24.617562 3.891043e+01 5.047952e+01 1.162420e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 7.797088e-65
## tlco 2.019103e+01 2.073837e-45
## kco 1.501340e+01 1.022601e-32
## Lymphocytes 6.490450e-01 3.997062e-03
## pd20 2.586920e+03 1.882103e-04
## FeNO 1.913459e+01 5.095285e-15
## Basophiles 4.440150e-02 3.418561e-17
## Eosinophiles 1.488999e-01 2.937138e-17
## Neutrophiles 1.348758e+00 8.759200e-21
## Monocytes 1.522671e-01 1.102948e-25
## Reversibility 6.697326e+00 1.080290e-26
## BMI 4.664452e+00 4.805194e-32
## pack_years 1.338584e+01 1.081791e-75
## onset_age_asthma 1.728090e+01 1.780114e-86
## Age 1.562341e+01 8.193317e-134
##
## $`2`
## v.test Mean in category Overall mean sd in category
## Age 23.034387 61.1710843 50.4795227 1.040746e+01
## pack_years 14.786572 17.1658343 11.2855015 1.521143e+01
## Monocytes 8.926795 0.4599759 0.4195937 1.616094e-01
## pd20 8.925972 3006.9618651 2320.9569182 2.671319e+03
## BMI 3.809601 27.1434454 26.6155247 4.402450e+00
## Neutrophiles 3.382222 3.8929759 3.7574492 1.400171e+00
## Lymphocytes 2.291474 2.0066265 1.9624411 6.726783e-01
## FEV1_FVC_ratio_post -3.210444 0.7748767 0.7832420 7.805921e-02
## FeNO -3.722770 20.9445181 23.0608030 1.350404e+01
## Reversibility -6.900426 4.5751215 5.9481072 5.391665e+00
## tlco -14.439403 91.1510245 99.8125910 1.435858e+01
## onset_age_asthma -17.749643 3.6590361 12.7716866 1.037934e+01
## kco -19.172814 88.8262484 97.3779717 1.248205e+01
## Overall sd p.value
## Age 1.562341e+01 2.109211e-117
## pack_years 1.338584e+01 1.788317e-49
## Monocytes 1.522671e-01 4.385270e-19
## pd20 2.586920e+03 4.418016e-19
## BMI 4.664452e+00 1.391915e-04
## Neutrophiles 1.348758e+00 7.190199e-04
## Lymphocytes 6.490450e-01 2.193603e-02
## FEV1_FVC_ratio_post 8.770554e-02 1.325301e-03
## FeNO 1.913459e+01 1.970486e-04
## Reversibility 6.697326e+00 5.184671e-12
## tlco 2.019103e+01 2.923624e-47
## onset_age_asthma 1.728090e+01 1.734537e-70
## kco 1.501340e+01 6.243815e-82
##
## $`3`
## v.test Mean in category Overall mean sd in category
## kco 18.577022 105.9894824 97.3779717 1.251941e+01
## tlco 13.567934 108.2711501 99.8125910 1.625090e+01
## Reversibility 4.284332 6.8340562 5.9481072 6.353456e+00
## FEV1_FVC_ratio_post 4.247071 0.7947431 0.7832420 7.242272e-02
## FeNO 3.716249 25.2563776 23.0608030 2.084064e+01
## onset_age_asthma 1.972178 13.8239796 12.7716866 1.021452e+01
## Neutrophiles -2.950449 3.6345791 3.7574492 1.255980e+00
## Monocytes -6.153533 0.3906633 0.4195937 1.272915e-01
## pd20 -8.469577 1644.4551761 2320.9569182 2.356000e+03
## pack_years -14.844298 5.1502902 11.2855015 5.037218e+00
## Age -19.836174 40.9107143 50.4795227 1.204095e+01
## Overall sd p.value
## kco 1.501340e+01 4.931191e-77
## tlco 2.019103e+01 6.204615e-42
## Reversibility 6.697326e+00 1.832888e-05
## FEV1_FVC_ratio_post 8.770554e-02 2.165836e-05
## FeNO 1.913459e+01 2.022020e-04
## onset_age_asthma 1.728090e+01 4.858927e-02
## Neutrophiles 1.348758e+00 3.173123e-03
## Monocytes 1.522671e-01 7.577558e-10
## pd20 2.586920e+03 2.462851e-17
## pack_years 1.338584e+01 7.574375e-50
## Age 1.562341e+01 1.450895e-871.5.3 Radar Plots
1.5.4 parallel box plots
1.5.5 parallel coordinate plot
1.6 Deep Empedding Clustering on the encoded data 3 clusters
1.6.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=915) | 1 (N=1337) | 2 (N=849) | Total (N=3101) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 42.278 (13.023) | 48.603 (15.510) | 62.274 (10.649) | 50.480 (15.626) | |
| Â Â Â Range | 17.000 - 78.000 | 17.000 - 97.000 | 18.000 - 86.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | ||||
| Â Â Â No | 321 (35.1%) | 635 (47.5%) | 378 (44.5%) | 1334 (43.0%) | |
| Â Â Â Yes | 594 (64.9%) | 702 (52.5%) | 471 (55.5%) | 1767 (57.0%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 26.381 (4.686) | 25.577 (3.966) | 28.503 (5.078) | 26.616 (4.665) | |
| Â Â Â Range | 16.534 - 42.595 | 16.975 - 45.435 | 17.603 - 50.058 | 16.534 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 14.754 (11.298) | 1.187 (5.250) | 28.879 (20.868) | 12.772 (17.284) | |
| Â Â Â Range | -1.000 - 70.000 | -1.000 - 32.000 | -1.000 - 72.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 629 (68.7%) | 1159 (86.7%) | 500 (58.9%) | 2288 (73.8%) | |
| Â Â Â Yes | 286 (31.3%) | 178 (13.3%) | 349 (41.1%) | 813 (26.2%) | |
| Breathlessness | < 0.001 | ||||
| Â Â Â No | 218 (23.8%) | 1165 (87.1%) | 286 (33.7%) | 1669 (53.8%) | |
| Â Â Â Yes | 697 (76.2%) | 172 (12.9%) | 563 (66.3%) | 1432 (46.2%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 758 (82.8%) | 1307 (97.8%) | 583 (68.7%) | 2648 (85.4%) | |
| Â Â Â Yes | 157 (17.2%) | 30 (2.2%) | 266 (31.3%) | 453 (14.6%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 783 (85.6%) | 1289 (96.4%) | 564 (66.4%) | 2636 (85.0%) | |
| Â Â Â Yes | 132 (14.4%) | 48 (3.6%) | 285 (33.6%) | 465 (15.0%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 762 (83.3%) | 1260 (94.2%) | 573 (67.5%) | 2595 (83.7%) | |
| Â Â Â Yes | 153 (16.7%) | 77 (5.8%) | 276 (32.5%) | 506 (16.3%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.796 (0.072) | 0.812 (0.060) | 0.725 (0.109) | 0.783 (0.088) | |
| Â Â Â Range | 0.444 - 1.009 | 0.571 - 1.180 | 0.230 - 1.590 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 6.660 (6.375) | 3.752 (3.734) | 8.640 (9.102) | 5.948 (6.698) | |
| Â Â Â Range | -26.774 - 53.704 | -12.603 - 38.626 | -6.858 - 77.242 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 1732.256 (2305.985) | 2571.254 (2946.660) | 2561.256 (2128.535) | 2320.957 (2587.337) | |
| Â Â Â Range | -6521.250 - 38775.000 | -26261.250 - 38775.000 | -3701.250 - 13923.750 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 106.268 (13.533) | 101.932 (22.107) | 89.517 (19.112) | 99.813 (20.194) | |
| Â Â Â Range | 44.477 - 161.534 | 48.844 - 680.093 | 44.453 - 389.709 | 44.453 - 680.093 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 104.585 (12.981) | 96.926 (13.537) | 90.322 (15.740) | 97.378 (15.016) | |
| Â Â Â Range | 40.972 - 149.720 | 28.161 - 139.983 | 43.704 - 141.410 | 28.161 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 25.856 (20.639) | 18.951 (10.902) | 26.520 (25.406) | 23.061 (19.138) | |
| Â Â Â Range | 3.300 - 155.000 | 0.000 - 102.000 | 3.400 - 226.000 | 0.000 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.205 (0.145) | 0.167 (0.110) | 0.248 (0.188) | 0.200 (0.149) | |
| Â Â Â Range | 0.000 - 1.100 | 0.000 - 0.900 | 0.000 - 2.300 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 3.624 (1.214) | 3.456 (1.158) | 4.375 (1.551) | 3.757 (1.349) | |
| Â Â Â Range | 1.000 - 10.600 | 0.700 - 11.000 | 1.300 - 12.500 | 0.700 - 12.500 | |
| Lymphocyties | < 0.001 | ||||
| Â Â Â Mean (SD) | 1.940 (0.712) | 1.903 (0.553) | 2.080 (0.701) | 1.962 (0.649) | |
| Â Â Â Range | 0.600 - 11.200 | 0.300 - 4.800 | 0.300 - 8.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.392 (0.127) | 0.395 (0.129) | 0.488 (0.186) | 0.420 (0.152) | |
| Â Â Â Range | 0.100 - 1.100 | 0.190 - 0.880 | 0.200 - 2.400 | 0.100 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.028 (0.044) | 0.017 (0.036) | 0.044 (0.052) | 0.028 (0.044) | |
| Â Â Â Range | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.300 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 245 (26.8%) | 305 (22.8%) | 394 (46.4%) | 944 (30.4%) | |
| Â Â Â Yes | 670 (73.2%) | 1032 (77.2%) | 455 (53.6%) | 2157 (69.6%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 343 (37.5%) | 905 (67.7%) | 589 (69.4%) | 1837 (59.2%) | |
| Â Â Â Yes | 572 (62.5%) | 432 (32.3%) | 260 (30.6%) | 1264 (40.8%) | |
| Drug_induced_dyspnea | < 0.001 | ||||
| Â Â Â No | 868 (94.9%) | 1326 (99.2%) | 790 (93.1%) | 2984 (96.2%) | |
| Â Â Â Yes | 47 (5.1%) | 11 (0.8%) | 59 (6.9%) | 117 (3.8%) | |
| nasal_plyposis | < 0.001 | ||||
| Â Â Â No | 563 (61.5%) | 735 (55.0%) | 435 (51.2%) | 1733 (55.9%) | |
| Â Â Â Yes | 352 (38.5%) | 602 (45.0%) | 414 (48.8%) | 1368 (44.1%) | |
| Ever_rhinitis | 0.162 | ||||
| Â Â Â No | 283 (30.9%) | 364 (27.2%) | 244 (28.7%) | 891 (28.7%) | |
| Â Â Â Yes | 632 (69.1%) | 973 (72.8%) | 605 (71.3%) | 2210 (71.3%) | |
| gina_steps | < 0.001 | ||||
| Â Â Â onlys saba or non users | 569 (62.2%) | 1202 (89.9%) | 581 (68.4%) | 2352 (75.8%) | |
| Â Â Â step 1 or 2 | 210 (23.0%) | 73 (5.5%) | 126 (14.8%) | 409 (13.2%) | |
| Â Â Â step3 | 54 (5.9%) | 26 (1.9%) | 38 (4.5%) | 118 (3.8%) | |
| Â Â Â step4 or 5 | 82 (9.0%) | 36 (2.7%) | 104 (12.2%) | 222 (7.2%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 890 (97.3%) | 1280 (95.7%) | 768 (90.5%) | 2938 (94.7%) | |
| Â Â Â Yes | 25 (2.7%) | 57 (4.3%) | 81 (9.5%) | 163 (5.3%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 800 (87.4%) | 1204 (90.1%) | 636 (74.9%) | 2640 (85.1%) | |
| Â Â Â Yes | 115 (12.6%) | 133 (9.9%) | 213 (25.1%) | 461 (14.9%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 774 (84.6%) | 1266 (94.7%) | 668 (78.7%) | 2708 (87.3%) | |
| Â Â Â Yes | 141 (15.4%) | 71 (5.3%) | 181 (21.3%) | 393 (12.7%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 353 (38.6%) | 729 (54.5%) | 262 (30.9%) | 1344 (43.3%) | |
| Â Â Â partially controlled | 448 (49.0%) | 526 (39.3%) | 417 (49.1%) | 1391 (44.9%) | |
| Â Â Â uncontrolled | 114 (12.5%) | 82 (6.1%) | 170 (20.0%) | 366 (11.8%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 538 (58.8%) | 683 (51.1%) | 270 (31.8%) | 1491 (48.1%) | |
| Â Â Â secondary | 336 (36.7%) | 528 (39.5%) | 358 (42.2%) | 1222 (39.4%) | |
| Â Â Â tertiary | 41 (4.5%) | 126 (9.4%) | 221 (26.0%) | 388 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 514 (56.2%) | 424 (31.7%) | 446 (52.5%) | 1384 (44.6%) | |
| Â Â Â Yes | 401 (43.8%) | 913 (68.3%) | 403 (47.5%) | 1717 (55.4%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 624 (68.2%) | 787 (58.9%) | 271 (31.9%) | 1682 (54.2%) | |
| Â Â Â former smokers | 246 (26.9%) | 467 (34.9%) | 435 (51.2%) | 1148 (37.0%) | |
| Â Â Â current smoker | 45 (4.9%) | 83 (6.2%) | 143 (16.8%) | 271 (8.7%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 5.894 (6.272) | 7.478 (7.859) | 23.093 (17.936) | 11.286 (13.388) | |
| Â Â Â Range | 0.000 - 55.500 | 0.000 - 52.500 | 0.000 - 112.500 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 401 (43.8%) | 545 (40.8%) | 238 (28.0%) | 1184 (38.2%) | |
| Â Â Â Yes | 514 (56.2%) | 792 (59.2%) | 611 (72.0%) | 1917 (61.8%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 646 (70.6%) | 849 (63.5%) | 366 (43.1%) | 1861 (60.0%) | |
| Â Â Â Yes | 269 (29.4%) | 488 (36.5%) | 483 (56.9%) | 1240 (40.0%) | |
| household_damage | 0.005 | ||||
| Â Â Â No | 781 (85.4%) | 1185 (88.6%) | 766 (90.2%) | 2732 (88.1%) | |
| Â Â Â Yes | 134 (14.6%) | 152 (11.4%) | 83 (9.8%) | 369 (11.9%) | |
| exertion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 133 (14.5%) | 1337 (100.0%) | 429 (50.5%) | 1899 (61.2%) | |
| Â Â Â Yes | 782 (85.5%) | 0 (0.0%) | 420 (49.5%) | 1202 (38.8%) | |
| infection_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 168 (18.4%) | 1337 (100.0%) | 422 (49.7%) | 1927 (62.1%) | |
| Â Â Â Yes | 747 (81.6%) | 0 (0.0%) | 427 (50.3%) | 1174 (37.9%) | |
| allergen_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 516 (56.4%) | 1335 (99.9%) | 687 (80.9%) | 2538 (81.8%) | |
| Â Â Â Yes | 399 (43.6%) | 2 (0.1%) | 162 (19.1%) | 563 (18.2%) | |
| irritant_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 738 (80.7%) | 1332 (99.6%) | 746 (87.9%) | 2816 (90.8%) | |
| Â Â Â Yes | 177 (19.3%) | 5 (0.4%) | 103 (12.1%) | 285 (9.2%) | |
| weather_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 509 (55.6%) | 1334 (99.8%) | 646 (76.1%) | 2489 (80.3%) | |
| Â Â Â Yes | 406 (44.4%) | 3 (0.2%) | 203 (23.9%) | 612 (19.7%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 803 (87.8%) | 1337 (100.0%) | 796 (93.8%) | 2936 (94.7%) | |
| Â Â Â Yes | 112 (12.2%) | 0 (0.0%) | 53 (6.2%) | 165 (5.3%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 877 (95.8%) | 1317 (98.5%) | 633 (74.6%) | 2827 (91.2%) | |
| Â Â Â Yes | 38 (4.2%) | 20 (1.5%) | 216 (25.4%) | 274 (8.8%) |
1.6.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## exertion_triggered_asthma 0.000000e+00 2
## infection_triggered_asthma 0.000000e+00 2
## Breathlessness 2.272918e-232 2
## allergen_triggered_asthma 8.572943e-151 2
## weather_triggered_asthma 1.179641e-148 2
## XCOPD 1.151374e-88 2
## dyspenea 2.671490e-80 2
## Recurrent_wheeze 1.129981e-78 2
## Chronic_productive_cough 7.564546e-60 2
## gina_steps 3.370793e-59 6
## smoking_status 5.131004e-59 4
## familial_allergy 4.308110e-56 2
## irritant_triggered_asthma 3.193236e-54 2
## education 3.593783e-54 4
## Cough 1.862771e-49 2
## gina_control 8.055494e-37 4
## emotion_triggered_asthma 3.082554e-36 2
## urbanization_level 1.051591e-35 2
## smoking_exposure_at_work 1.976172e-33 2
## spt_any 3.669845e-32 2
## severe_asthma 9.591289e-29 2
## Emergency_last_year 2.514358e-22 2
## Drug_induced_dyspnea 7.924520e-14 2
## smoking_exposure_at_home 2.849218e-12 2
## Hosptalization_last_year 1.225427e-10 2
## Gender 2.245854e-08 2
## nasal_plyposis 5.227827e-05 2
## household_damage 5.020449e-03 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 65.058236 85.464481 38.761690 7.218050e-272
## infection_triggered_asthma=Yes 63.628620 81.639344 37.858755 4.910179e-237
## allergen_triggered_asthma=Yes 70.870337 43.606557 18.155434 7.621766e-115
## Breathlessness=Yes 48.673184 76.174863 46.178652 3.383504e-107
## weather_triggered_asthma=Yes 66.339869 44.371585 19.735569 1.377704e-101
## familial_allergy=Yes 45.253165 62.513661 40.761045 8.262743e-57
## irritant_triggered_asthma=Yes 62.105263 19.344262 9.190584 3.499164e-33
## emotion_triggered_asthma=Yes 67.878788 12.240437 5.320864 1.318076e-25
## smoking_status=never smoker 37.098692 68.196721 54.240568 2.304946e-24
## gina_steps=step 1 or 2 51.344743 22.950820 13.189294 1.986089e-23
## urbanization_level=No 37.138728 56.174863 44.630764 6.920431e-17
## smoking_exposure_at_work=No 34.712520 70.601093 60.012899 3.409947e-15
## education=primary 36.083166 58.797814 48.081264 1.062123e-14
## XCOPD=No 31.022285 95.846995 91.164141 2.673588e-10
## Gender=Yes 33.616299 64.918033 56.981619 6.423747e-09
## Hosptalization_last_year=No 30.292716 97.267760 94.743631 1.788467e-05
## smoking_exposure_at_home=No 33.868243 43.825137 38.181232 3.123175e-05
## nasal_plyposis=No 32.487017 61.530055 55.885198 4.023982e-05
## Cough=Yes 35.178352 31.256831 26.217349 4.431821e-05
## gina_steps=step3 45.762712 5.901639 3.805224 1.492154e-04
## household_damage=Yes 36.314363 14.644809 11.899387 2.665343e-03
## gina_control=partially controlled 32.207045 48.961749 44.856498 2.994355e-03
## severe_asthma=Yes 35.877863 15.409836 12.673331 3.526632e-03
## spt_any=Yes 31.061660 73.224044 69.558207 3.904631e-03
## Recurrent_wheeze=Yes 34.657837 17.158470 14.608191 1.017457e-02
## Drug_induced_dyspnea=Yes 40.170940 5.136612 3.772976 1.217942e-02
## gina_steps=step4 or 5 36.936937 8.961749 7.158981 1.345018e-02
## Emergency_last_year=No 30.303030 87.431694 85.133828 1.880561e-02
## education=secondary 27.495908 36.721311 39.406643 4.747970e-02
## Emergency_last_year=Yes 24.945770 12.568306 14.866172 1.880561e-02
## Drug_induced_dyspnea=No 29.088472 94.863388 96.227024 1.217942e-02
## Recurrent_wheeze=No 28.625378 82.841530 85.391809 1.017457e-02
## spt_any=No 25.953390 26.775956 30.441793 3.904631e-03
## severe_asthma=No 28.581979 84.590164 87.326669 3.526632e-03
## household_damage=No 28.587116 85.355191 88.100613 2.665343e-03
## gina_control=controlled 26.264881 38.579235 43.340858 5.223029e-04
## Cough=No 27.491259 68.743169 73.782651 4.431821e-05
## nasal_plyposis=Yes 25.730994 38.469945 44.114802 4.023982e-05
## smoking_exposure_at_home=Yes 26.812728 56.174863 61.818768 3.123175e-05
## Hosptalization_last_year=Yes 15.337423 2.732240 5.256369 1.788467e-05
## smoking_status=current smoker 16.605166 4.918033 8.739116 3.361517e-07
## Gender=No 24.062969 35.081967 43.018381 6.423747e-09
## XCOPD=Yes 13.868613 4.153005 8.835859 2.673588e-10
## smoking_status=former smokers 21.428571 26.885246 37.020316 1.771927e-14
## smoking_exposure_at_work=Yes 21.693548 29.398907 39.987101 3.409947e-15
## urbanization_level=Yes 23.354688 43.825137 55.369236 6.920431e-17
## education=tertiary 10.567010 4.480874 12.512093 2.711269e-21
## emotion_triggered_asthma=No 27.350136 87.759563 94.679136 1.318076e-25
## gina_steps=onlys saba or non users 24.192177 62.185792 75.846501 4.030401e-29
## irritant_triggered_asthma=No 26.207386 80.655738 90.809416 3.499164e-33
## familial_allergy=No 18.671747 37.486339 59.238955 8.262743e-57
## weather_triggered_asthma=No 20.449980 55.628415 80.264431 1.377704e-101
## Breathlessness=No 13.061714 23.825137 53.821348 3.383504e-107
## allergen_triggered_asthma=No 20.330969 56.393443 81.844566 7.621766e-115
## infection_triggered_asthma=No 8.718215 18.360656 62.141245 4.910179e-237
## exertion_triggered_asthma=No 7.003686 14.535519 61.238310 7.218050e-272
## v.test
## exertion_triggered_asthma=Yes 35.228911
## infection_triggered_asthma=Yes 32.875581
## allergen_triggered_asthma=Yes 22.777743
## Breathlessness=Yes 21.992687
## weather_triggered_asthma=Yes 21.398570
## familial_allergy=Yes 15.883363
## irritant_triggered_asthma=Yes 12.001263
## emotion_triggered_asthma=Yes 10.460035
## smoking_status=never smoker 10.185364
## gina_steps=step 1 or 2 9.973739
## urbanization_level=No 8.348382
## smoking_exposure_at_work=No 7.874908
## education=primary 7.731589
## XCOPD=No 6.316613
## Gender=Yes 5.805335
## Hosptalization_last_year=No 4.289784
## smoking_exposure_at_home=No 4.164294
## nasal_plyposis=No 4.106098
## Cough=Yes 4.083732
## gina_steps=step3 3.792372
## household_damage=Yes 3.003910
## gina_control=partially controlled 2.968317
## severe_asthma=Yes 2.917665
## spt_any=Yes 2.885765
## Recurrent_wheeze=Yes 2.569839
## Drug_induced_dyspnea=Yes 2.506903
## gina_steps=step4 or 5 2.471622
## Emergency_last_year=No 2.349362
## education=secondary -1.981996
## Emergency_last_year=Yes -2.349362
## Drug_induced_dyspnea=No -2.506903
## Recurrent_wheeze=No -2.569839
## spt_any=No -2.885765
## severe_asthma=No -2.917665
## household_damage=No -3.003910
## gina_control=controlled -3.469050
## Cough=No -4.083732
## nasal_plyposis=Yes -4.106098
## smoking_exposure_at_home=Yes -4.164294
## Hosptalization_last_year=Yes -4.289784
## smoking_status=current smoker -5.101961
## Gender=No -5.805335
## XCOPD=Yes -6.316613
## smoking_status=former smokers -7.666181
## smoking_exposure_at_work=Yes -7.874908
## urbanization_level=Yes -8.348382
## education=tertiary -9.473305
## emotion_triggered_asthma=No -10.460035
## gina_steps=onlys saba or non users -11.201026
## irritant_triggered_asthma=No -12.001263
## familial_allergy=No -15.883363
## weather_triggered_asthma=No -21.398570
## Breathlessness=No -21.992687
## allergen_triggered_asthma=No -22.777743
## infection_triggered_asthma=No -32.875581
## exertion_triggered_asthma=No -35.228911
##
## $`1`
## Cla/Mod Mod/Cla Global
## infection_triggered_asthma=No 69.3824598 100.0000000 62.141245
## exertion_triggered_asthma=No 70.4054766 100.0000000 61.238310
## Breathlessness=No 69.8022768 87.1353777 53.821348
## weather_triggered_asthma=No 53.5958216 99.7756171 80.264431
## allergen_triggered_asthma=No 52.6004728 99.8504114 81.844566
## Recurrent_wheeze=No 49.3580060 97.7561705 85.391809
## irritant_triggered_asthma=No 47.3011364 99.6260284 90.809416
## dyspenea=No 48.8998483 96.4098728 85.004837
## gina_steps=onlys saba or non users 51.1054422 89.9027674 75.846501
## Cough=No 50.6555944 86.6866118 73.782651
## Chronic_productive_cough=No 48.5549133 94.2408377 83.682683
## XCOPD=No 46.5864874 98.5041137 91.164141
## emotion_triggered_asthma=No 45.5381471 100.0000000 94.679136
## urbanization_level=Yes 53.1741409 68.2872102 55.369236
## severe_asthma=No 46.7503693 94.6896036 87.326669
## gina_control=controlled 54.2410714 54.5250561 43.340858
## familial_allergy=No 49.2651062 67.6888556 59.238955
## Drug_induced_dyspnea=No 44.4369973 99.1772625 96.227024
## spt_any=Yes 47.8442281 77.1877337 69.558207
## Emergency_last_year=No 45.6060606 90.0523560 85.133828
## smoking_status=never smoker 46.7895363 58.8631264 54.240568
## Gender=No 47.6011994 47.4943904 43.018381
## smoking_exposure_at_work=No 45.6206341 63.5003740 60.012899
## education=primary 45.8081824 51.0845176 48.081264
## smoking_exposure_at_home=No 46.0304054 40.7629020 38.181232
## Hosptalization_last_year=No 43.5670524 95.7367240 94.743631
## smoking_status=former smokers 40.6794425 34.9289454 37.020316
## Hosptalization_last_year=Yes 34.9693252 4.2632760 5.256369
## smoking_exposure_at_home=Yes 41.3145540 59.2370980 61.818768
## smoking_exposure_at_work=Yes 39.3548387 36.4996260 39.987101
## Gender=Yes 39.7283531 52.5056096 56.981619
## smoking_status=current smoker 30.6273063 6.2079282 8.739116
## education=tertiary 32.4742268 9.4240838 12.512093
## gina_steps=step3 22.0338983 1.9446522 3.805224
## gina_control=partially controlled 37.8145219 39.3418100 44.856498
## Emergency_last_year=Yes 28.8503254 9.9476440 14.866172
## spt_any=No 32.3093220 22.8122663 30.441793
## Drug_induced_dyspnea=Yes 9.4017094 0.8227375 3.772976
## familial_allergy=Yes 34.1772152 32.3111444 40.761045
## gina_control=uncontrolled 22.4043716 6.1331339 11.802644
## gina_steps=step4 or 5 16.2162162 2.6925954 7.158981
## severe_asthma=Yes 18.0661578 5.3103964 12.673331
## gina_steps=step 1 or 2 17.8484108 5.4599850 13.189294
## urbanization_level=No 30.6358382 31.7127898 44.630764
## emotion_triggered_asthma=Yes 0.0000000 0.0000000 5.320864
## XCOPD=Yes 7.2992701 1.4958863 8.835859
## Chronic_productive_cough=Yes 15.2173913 5.7591623 16.317317
## Cough=Yes 21.8942189 13.3133882 26.217349
## dyspenea=Yes 10.3225806 3.5901272 14.995163
## irritant_triggered_asthma=Yes 1.7543860 0.3739716 9.190584
## Recurrent_wheeze=Yes 6.6225166 2.2438295 14.608191
## allergen_triggered_asthma=Yes 0.3552398 0.1495886 18.155434
## weather_triggered_asthma=Yes 0.4901961 0.2243829 19.735569
## Breathlessness=Yes 12.0111732 12.8646223 46.178652
## infection_triggered_asthma=Yes 0.0000000 0.0000000 37.858755
## exertion_triggered_asthma=Yes 0.0000000 0.0000000 38.761690
## p.value v.test
## infection_triggered_asthma=No 0.000000e+00 Inf
## exertion_triggered_asthma=No 0.000000e+00 Inf
## Breathlessness=No 2.296636e-250 33.795498
## weather_triggered_asthma=No 2.561365e-167 27.569815
## allergen_triggered_asthma=No 1.199004e-153 26.405047
## Recurrent_wheeze=No 1.874262e-77 18.628874
## irritant_triggered_asthma=No 2.795687e-65 17.063050
## dyspenea=No 3.468607e-62 16.641829
## gina_steps=onlys saba or non users 2.304661e-61 16.528054
## Cough=No 2.431518e-48 14.609822
## Chronic_productive_cough=No 4.228968e-48 14.572067
## XCOPD=No 4.146865e-43 13.764860
## emotion_triggered_asthma=No 1.158892e-42 13.690388
## urbanization_level=Yes 7.480260e-37 12.681586
## severe_asthma=No 4.073327e-29 11.200087
## gina_control=controlled 6.809567e-28 10.947781
## familial_allergy=No 5.663091e-17 8.372036
## Drug_induced_dyspnea=No 4.034864e-16 8.137511
## spt_any=Yes 5.315586e-16 8.104058
## Emergency_last_year=No 9.621759e-12 6.812050
## smoking_status=never smoker 6.775135e-06 4.500633
## Gender=No 1.196663e-05 4.378195
## smoking_exposure_at_work=No 5.522666e-04 3.454035
## education=primary 3.586942e-03 2.912373
## smoking_exposure_at_home=No 1.009184e-02 2.572667
## Hosptalization_last_year=No 3.028243e-02 2.166376
## smoking_status=former smokers 3.571916e-02 -2.100110
## Hosptalization_last_year=Yes 3.028243e-02 -2.166376
## smoking_exposure_at_home=Yes 1.009184e-02 -2.572667
## smoking_exposure_at_work=Yes 5.522666e-04 -3.454035
## Gender=Yes 1.196663e-05 -4.378195
## smoking_status=current smoker 1.069716e-05 -4.402579
## education=tertiary 4.848325e-06 -4.571246
## gina_steps=step3 1.172570e-06 -4.860217
## gina_control=partially controlled 7.389544e-08 -5.381432
## Emergency_last_year=Yes 9.621759e-12 -6.812050
## spt_any=No 5.315586e-16 -8.104058
## Drug_induced_dyspnea=Yes 4.034864e-16 -8.137511
## familial_allergy=Yes 5.663091e-17 -8.372036
## gina_control=uncontrolled 1.560310e-18 -8.785240
## gina_steps=step4 or 5 9.904803e-19 -8.836179
## severe_asthma=Yes 4.073327e-29 -11.200087
## gina_steps=step 1 or 2 6.203256e-31 -11.564943
## urbanization_level=No 7.480260e-37 -12.681586
## emotion_triggered_asthma=Yes 1.158892e-42 -13.690388
## XCOPD=Yes 4.146865e-43 -13.764860
## Chronic_productive_cough=Yes 4.228968e-48 -14.572067
## Cough=Yes 2.431518e-48 -14.609822
## dyspenea=Yes 3.468607e-62 -16.641829
## irritant_triggered_asthma=Yes 2.795687e-65 -17.063050
## Recurrent_wheeze=Yes 1.874262e-77 -18.628874
## allergen_triggered_asthma=Yes 1.199004e-153 -26.405047
## weather_triggered_asthma=Yes 2.561365e-167 -27.569815
## Breathlessness=Yes 2.296636e-250 -33.795498
## infection_triggered_asthma=Yes 0.000000e+00 -Inf
## exertion_triggered_asthma=Yes 0.000000e+00 -Inf
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 78.83212 25.441696 8.835859 5.312393e-78
## dyspenea=Yes 61.29032 33.568905 14.995163 2.496576e-63
## Recurrent_wheeze=Yes 58.71965 31.330978 14.608191 7.101052e-53
## Chronic_productive_cough=Yes 54.54545 32.508834 16.317317 4.953399e-46
## Breathlessness=Yes 39.31564 66.313310 46.178652 1.187385e-43
## education=tertiary 56.95876 26.030624 12.512093 1.001390e-39
## smoking_exposure_at_work=Yes 38.95161 56.890459 39.987101 1.125033e-31
## spt_any=No 41.73729 46.407538 30.441793 3.390311e-31
## Cough=Yes 42.92743 41.107185 26.217349 1.890381e-29
## smoking_status=former smokers 37.89199 51.236749 37.020316 2.348976e-23
## Emergency_last_year=Yes 46.20390 25.088339 14.866172 4.639422e-21
## smoking_status=current smoker 52.76753 16.843345 8.739116 1.917860e-20
## infection_triggered_asthma=Yes 36.37138 50.294464 37.858755 3.805386e-18
## severe_asthma=Yes 46.05598 21.319199 12.673331 1.841273e-17
## gina_control=uncontrolled 46.44809 20.023557 11.802644 8.382293e-17
## exertion_triggered_asthma=Yes 34.94176 49.469965 38.761690 8.900175e-14
## smoking_exposure_at_home=Yes 31.87272 71.967020 61.818768 4.619318e-13
## familial_allergy=No 32.06315 69.375736 59.238955 1.033088e-12
## gina_steps=step4 or 5 46.84685 12.249706 7.158981 1.330593e-10
## Hosptalization_last_year=Yes 49.69325 9.540636 5.256369 5.458456e-10
## urbanization_level=No 32.22543 52.532391 44.630764 5.949467e-08
## Drug_induced_dyspnea=Yes 50.42735 6.949352 3.772976 7.739066e-08
## weather_triggered_asthma=Yes 33.16993 23.910483 19.735569 4.090375e-04
## irritant_triggered_asthma=Yes 36.14035 12.131920 9.190584 6.892978e-04
## nasal_plyposis=Yes 30.26316 48.763251 44.114802 1.405966e-03
## gina_control=partially controlled 29.97843 49.116608 44.856498 3.468497e-03
## household_damage=No 28.03807 90.223793 88.100613 2.322580e-02
## household_damage=Yes 22.49322 9.776207 11.899387 2.322580e-02
## nasal_plyposis=No 25.10098 51.236749 55.885198 1.405966e-03
## irritant_triggered_asthma=No 26.49148 87.868080 90.809416 6.892978e-04
## weather_triggered_asthma=No 25.95420 76.089517 80.264431 4.090375e-04
## Drug_induced_dyspnea=No 26.47453 93.050648 96.227024 7.739066e-08
## urbanization_level=Yes 23.47117 47.467609 55.369236 5.949467e-08
## gina_steps=onlys saba or non users 24.70238 68.433451 75.846501 6.116967e-09
## Hosptalization_last_year=No 26.14023 90.459364 94.743631 5.458456e-10
## familial_allergy=Yes 20.56962 30.624264 40.761045 1.033088e-12
## smoking_exposure_at_home=No 20.10135 28.032980 38.181232 4.619318e-13
## exertion_triggered_asthma=No 22.59084 50.530035 61.238310 8.900175e-14
## severe_asthma=No 24.66765 78.680801 87.326669 1.841273e-17
## infection_triggered_asthma=No 21.89933 49.705536 62.141245 3.805386e-18
## gina_control=controlled 19.49405 30.859835 43.340858 3.201017e-18
## Emergency_last_year=No 24.09091 74.911661 85.133828 4.639422e-21
## education=primary 18.10865 31.802120 48.081264 2.590682e-29
## Cough=No 21.85315 58.892815 73.782651 1.890381e-29
## spt_any=Yes 21.09411 53.592462 69.558207 3.390311e-31
## smoking_exposure_at_work=No 19.66685 43.109541 60.012899 1.125033e-31
## Breathlessness=No 17.13601 33.686690 53.821348 1.187385e-43
## Chronic_productive_cough=No 22.08092 67.491166 83.682683 4.953399e-46
## Recurrent_wheeze=No 22.01662 68.669022 85.391809 7.101052e-53
## smoking_status=never smoker 16.11177 31.919906 54.240568 2.065319e-53
## dyspenea=No 21.39605 66.431095 85.004837 2.496576e-63
## XCOPD=No 22.39123 74.558304 91.164141 5.312393e-78
## v.test
## XCOPD=Yes 18.696237
## dyspenea=Yes 16.798651
## Recurrent_wheeze=Yes 15.304809
## Chronic_productive_cough=Yes 14.243027
## Breathlessness=Yes 13.854951
## education=tertiary 13.190035
## smoking_exposure_at_work=Yes 11.710583
## spt_any=No 11.616687
## Cough=Yes 11.267894
## smoking_status=former smokers 9.957064
## Emergency_last_year=Yes 9.417049
## smoking_status=current smoker 9.266816
## infection_triggered_asthma=Yes 8.684462
## severe_asthma=Yes 8.503394
## gina_control=uncontrolled 8.325713
## exertion_triggered_asthma=Yes 7.456277
## smoking_exposure_at_home=Yes 7.236053
## familial_allergy=No 7.126025
## gina_steps=step4 or 5 6.423634
## Hosptalization_last_year=Yes 6.205323
## urbanization_level=No 5.420313
## Drug_induced_dyspnea=Yes 5.373109
## weather_triggered_asthma=Yes 3.534183
## irritant_triggered_asthma=Yes 3.393801
## nasal_plyposis=Yes 3.193423
## gina_control=partially controlled 2.922845
## household_damage=No 2.269700
## household_damage=Yes -2.269700
## nasal_plyposis=No -3.193423
## irritant_triggered_asthma=No -3.393801
## weather_triggered_asthma=No -3.534183
## Drug_induced_dyspnea=No -5.373109
## urbanization_level=Yes -5.420313
## gina_steps=onlys saba or non users -5.813528
## Hosptalization_last_year=No -6.205323
## familial_allergy=Yes -7.126025
## smoking_exposure_at_home=No -7.236053
## exertion_triggered_asthma=No -7.456277
## severe_asthma=No -8.503394
## infection_triggered_asthma=No -8.684462
## gina_control=controlled -8.704101
## Emergency_last_year=No -9.417049
## education=primary -11.240107
## Cough=No -11.267894
## spt_any=Yes -11.616687
## smoking_exposure_at_work=No -11.710583
## Breathlessness=No -13.854951
## Chronic_productive_cough=No -14.243027
## Recurrent_wheeze=No -15.304809
## smoking_status=never smoker -15.384951
## dyspenea=No -16.798651
## XCOPD=No -18.696237
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## onset_age_asthma 0.43549352 0.000000e+00
## pack_years 0.29578586 1.243484e-236
## Age 0.24358432 1.585068e-188
## FEV1_FVC_ratio_post 0.17448983 1.007036e-129
## kco 0.12884219 1.621791e-93
## tlco 0.10609253 3.566026e-76
## Reversibility 0.09390223 4.615022e-67
## Neutrophiles 0.08182664 3.718283e-58
## Monocytes 0.07657845 2.538682e-54
## BMI 0.06692974 2.496460e-47
## Basophiles 0.06021054 1.676307e-42
## Eosinophiles 0.04963974 5.609561e-35
## FeNO 0.03513386 8.699329e-25
## pd20 0.02167925 1.800861e-15
## Lymphocytes 0.01293481 1.744619e-09
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## kco 17.290929 104.5845835 97.3779717 1.297344e+01
## tlco 11.516824 106.2680175 99.8125910 1.352593e+01
## FeNO 5.262846 25.8563934 23.0608030 2.062754e+01
## FEV1_FVC_ratio_post 5.047385 0.7955313 0.7832420 7.236936e-02
## onset_age_asthma 4.132318 14.7540984 12.7716866 1.129165e+01
## Reversibility 3.826344 6.6595158 5.9481072 6.372002e+00
## Neutrophiles -3.560000 3.6241530 3.7574492 1.213020e+00
## Monocytes -6.476137 0.3922186 0.4195937 1.271211e-01
## pd20 -8.197434 1732.2561008 2320.9569182 2.304724e+03
## pack_years -14.509102 5.8938732 11.2855015 6.268824e+00
## Age -18.910648 42.2775956 50.4795227 1.301582e+01
## Overall sd p.value
## kco 1.501340e+01 5.505752e-67
## tlco 2.019103e+01 1.085381e-30
## FeNO 1.913459e+01 1.418423e-07
## FEV1_FVC_ratio_post 8.770554e-02 4.478988e-07
## onset_age_asthma 1.728090e+01 3.591225e-05
## Reversibility 6.697326e+00 1.300606e-04
## Neutrophiles 1.348758e+00 3.708542e-04
## Monocytes 1.522671e-01 9.410034e-11
## pd20 2.586920e+03 2.455733e-16
## pack_years 1.338584e+01 1.061008e-47
## Age 1.562341e+01 9.320477e-80
##
## $`1`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 15.916520 8.120410e-01 7.832420e-01 6.015482e-02
## tlco 5.088505 1.019322e+02 9.981259e+01 2.209885e+01
## pd20 4.689970 2.571254e+03 2.320957e+03 2.945558e+03
## Lymphocytes -4.413052 1.903351e+00 1.962441e+00 5.532581e-01
## Age -5.822531 4.860284e+01 5.047952e+01 1.550400e+01
## Monocytes -7.904155 3.947644e-01 4.195937e-01 1.287508e-01
## FeNO -10.410850 1.895112e+01 2.306080e+01 1.089827e+01
## BMI -10.787659 2.557745e+01 2.661552e+01 3.964018e+00
## Neutrophiles -10.821940 3.456328e+00 3.757449e+00 1.157809e+00
## Eosinophiles -10.857096 1.670681e-01 2.004192e-01 1.095387e-01
## Basophiles -11.324799 1.742708e-02 2.780071e-02 3.572677e-02
## pack_years -13.789261 7.477567e+00 1.128550e+01 7.856418e+00
## Reversibility -15.893819 3.752107e+00 5.948107e+00 3.732639e+00
## onset_age_asthma -32.494934 1.186986e+00 1.277169e+01 5.248446e+00
## Overall sd p.value
## FEV1_FVC_ratio_post 8.770554e-02 4.867080e-57
## tlco 2.019103e+01 3.608966e-07
## pd20 2.586920e+03 2.732446e-06
## Lymphocytes 6.490450e-01 1.019234e-05
## Age 1.562341e+01 5.796309e-09
## Monocytes 1.522671e-01 2.697576e-15
## FeNO 1.913459e+01 2.212379e-25
## BMI 4.664452e+00 3.936916e-27
## Neutrophiles 1.348758e+00 2.709786e-27
## Eosinophiles 1.488999e-01 1.845242e-27
## Basophiles 4.440150e-02 9.890495e-30
## pack_years 1.338584e+01 2.957725e-43
## Reversibility 6.697326e+00 6.993348e-57
## onset_age_asthma 1.728090e+01 1.257292e-231
##
## $`2`
## v.test Mean in category Overall mean sd in category
## onset_age_asthma 31.863875 2.887868e+01 1.277169e+01 2.085534e+01
## pack_years 30.155178 2.309298e+01 1.128550e+01 1.792562e+01
## Age 25.808906 6.227444e+01 5.047952e+01 1.064244e+01
## Neutrophiles 15.660607 4.375312e+00 3.757449e+00 1.550468e+00
## Monocytes 15.402642 4.881979e-01 4.195937e-01 1.862226e-01
## BMI 13.833431 2.850299e+01 2.661552e+01 5.075465e+00
## Reversibility 13.738813 8.639643e+00 5.948107e+00 9.096563e+00
## Basophiles 12.512268 4.405183e-02 2.780071e-02 5.148515e-02
## Eosinophiles 10.874930 2.477856e-01 2.004192e-01 1.879999e-01
## Lymphocytes 6.196964 2.080094e+00 1.962441e+00 7.007615e-01
## FeNO 6.179879 2.651979e+01 2.306080e+01 2.539117e+01
## pd20 3.175555 2.561256e+03 2.320957e+03 2.127281e+03
## kco -16.065740 9.032245e+01 9.737797e+01 1.573121e+01
## tlco -17.431139 8.951741e+01 9.981259e+01 1.910079e+01
## FEV1_FVC_ratio_post -22.840218 7.246448e-01 7.832420e-01 1.088610e-01
## Overall sd p.value
## onset_age_asthma 1.728090e+01 8.456842e-223
## pack_years 1.338584e+01 9.174216e-200
## Age 1.562341e+01 7.044004e-147
## Neutrophiles 1.348758e+00 2.812013e-55
## Monocytes 1.522671e-01 1.571158e-53
## BMI 4.664452e+00 1.601934e-43
## Reversibility 6.697326e+00 5.944198e-43
## Basophiles 4.440150e-02 6.397123e-36
## Eosinophiles 1.488999e-01 1.517715e-27
## Lymphocytes 6.490450e-01 5.756272e-10
## FeNO 1.913459e+01 6.415069e-10
## pd20 2.586920e+03 1.495500e-03
## kco 1.501340e+01 4.435369e-58
## tlco 2.019103e+01 4.788266e-68
## FEV1_FVC_ratio_post 8.770554e-02 1.828093e-1151.6.3 Radar Plots
1.6.4 parallel box plots
1.6.5 parallel coordinate plot
